Zobrazeno 1 - 10 of 94 pro vyhledávání: '"Tatsuya, Fujioka"'
1
Akademický článek
Citrin-deficient patient-derived induced pluripotent stem cells as a pathological liver model for congenital urea cycle disorders
Autor: Mai Okano, Masahiro Yasuda, Yui Shimomura, Yoshikazu Matsuoka, Yasumasa Shirouzu, Tatsuya Fujioka, Masatoshi Kyo, Shoji Tsuji, Kazunari Kaneko, Hirofumi Hitomi
Publikováno v: Molecular Genetics and Metabolism Reports, Vol 40, Iss , Pp 101096- (2024)
Citrin deficiency is a congenital secondary urea cycle disorder lacking useful disease models for effective treatment development. In this study, human induced pluripotent stem cells (iPSCs) were generated from two patients with citrin deficiency and
Externí odkaz: https://doaj.org/article/f8d08f606ce54fac965a4584293e616a
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2
Akademický článek
Efficient protocol for the differentiation of kidney podocytes from induced pluripotent stem cells, involving the inhibition of mTOR
Autor: Masahiro Yasuda, Tadashi Kato, Mai Okano, Hiromi Yamashita, Yoshikazu Matsuoka, Yasumasa Shirouzu, Tatsuya Fujioka, Fumiyuki Hattori, Shoji Tsuji, Kazunari Kaneko, Hirofumi Hitomi
Publikováno v: Scientific Reports, Vol 13, Iss 1, Pp 1-12 (2023)
Abstract The mechanistic/mammalian target of rapamycin (mTOR) is involved in a wide range of cellular processes. However, the role of mTOR in podocytes remains unclear. In this study, we aimed to clarify the role of mTOR in podocyte differentiation f
Externí odkaz: https://doaj.org/article/1214bdda34164203b7da890f5b895cce
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3
Akademický článek
Long-term outcome of C1-esterase inhibitor deficiency.
Autor: Luong Hoang Long, Tatsuya Fujioka, Craig, Timothy J., Hirofumi Hitomi
Publikováno v: Asian Pacific Journal of Allergy & Immunology; Sep2024, Vol. 42 Issue 3, p222-232, 11p
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4
Akademický článek
A revised road map for the commitment of human cord blood CD34-negative hematopoietic stem cells
Autor: Keisuke Sumide, Yoshikazu Matsuoka, Hiroshi Kawamura, Ryusuke Nakatsuka, Tatsuya Fujioka, Hiroaki Asano, Yoshihiro Takihara, Yoshiaki Sonoda
Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
Single CD34 negative haematopoietic stem cells (HSCs) can fully reconstitute lympho-myeloid hematopoiesis in mice. Here, using single cell transplantation and gene expression analyses, the authors show that CD34 negative HSCs lie at the apex of haema
Externí odkaz: https://doaj.org/article/c550f20a25a54ac691d698a7862e3926
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5
Akademický článek
TGF-β Signaling Accelerates Senescence of Human Bone-Derived CD271 and SSEA-4 Double-Positive Mesenchymal Stromal Cells
Autor: Hiroshi Kawamura, Ryusuke Nakatsuka, Yoshikazu Matsuoka, Keisuke Sumide, Tatsuya Fujioka, Hiroaki Asano, Hirokazu Iida, Yoshiaki Sonoda
Publikováno v: Stem Cell Reports, Vol 10, Iss 3, Pp 920-932 (2018)
Summary: It is generally thought that the proliferative capacity and differentiation potential of somatic stem cells, including mesenchymal stromal/stem cells (MSCs) and hematopoietic stem cells, decline with age. We investigated the effects of aging
Externí odkaz: https://doaj.org/article/5f5a7e1da36b46b0ba21b138e76fed2d
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9
Akademický článek
CD34 Antigen and the MPL Receptor Expression Defines a Novel Class of Human Cord Blood-Derived Primitive Hematopoietic Stem Cells
Autor: Yoshikazu Matsuoka, Masaya Takahashi, Keisuke Sumide, Hiroshi Kawamura, Ryusuke Nakatsuka, Tatsuya Fujioka, Yoshiaki Sonoda M.D., Ph.D.
Publikováno v: Cell Transplantation, Vol 26 (2017)
In the murine hematopoietic stem cell (HSC) compartment, thrombopoietin (THPO)/MPL (THPO receptor) signaling plays an important role in the maintenance of adult quiescent HSCs. However, the role of THPO/MPL signaling in the human primitive HSC compar
Externí odkaz: https://doaj.org/article/af009ca6a1694058b05ca1c4d3a0a2c5
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