Zobrazeno 1 - 10
of 88
pro vyhledávání: '"Tatsushi Igaki"'
Autor:
Bungo Kakemura, Tatsushi Igaki
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-10 (2024)
Abstract Selective elimination of cancer cells without causing deleterious effects on normal cells is an ideal anti-cancer strategy. Here, using Drosophila cancer model, we performed an in vivo RNAi screen for anti-cancer targets that selectively eli
Externí odkaz:
https://doaj.org/article/7fa883dafd6b4f3da767a00734af8674
Publikováno v:
Cell Structure and Function, Vol 49, Iss 1, Pp 11-20 (2024)
The ribosome is a molecular machine essential for protein synthesis, which is composed of approximately 80 different ribosomal proteins (Rps). Studies in yeast and cell culture systems have revealed that the intracellular level of Rps is finely regul
Externí odkaz:
https://doaj.org/article/ea73a41e7a5040609ba4c177a90465cc
Publikováno v:
Fly, Vol 17, Iss 1 (2023)
Externí odkaz:
https://doaj.org/article/4d0e924a5f964c5080ba67ce77150084
Autor:
Masato Enomoto, Tatsushi Igaki
Publikováno v:
Fly, Vol 16, Iss 1, Pp 367-381 (2022)
Cell-cell interactions within tumour microenvironment play crucial roles in tumorigenesis. Genetic mosaic techniques available in Drosophila have provided a powerful platform to study the basic principles of tumour growth and progression via cell-cel
Externí odkaz:
https://doaj.org/article/2efb956f15e94d799404dbfb73939fd3
Autor:
Kiichiro Taniguchi, Tatsushi Igaki
Publikováno v:
PLoS Genetics, Vol 19, Iss 3, p e1010684 (2023)
The function of the stem cell system is supported by a stereotypical shape of the niche structure. In Drosophila ovarian germarium, somatic cap cells form a dish-like niche structure that allows only two or three germ-line stem cells (GSCs) reside in
Externí odkaz:
https://doaj.org/article/6e3ac37ea76d44e69432a8facc1f7625
Publikováno v:
eLife, Vol 11 (2022)
JNK signaling plays a critical role in both tumor promotion and tumor suppression. Here, we identified clustered microRNAs (miRNAs) miR-306 and miR-79 as novel tumor-suppressor miRNAs that specifically eliminate JNK-activated tumors in Drosophila. Wh
Externí odkaz:
https://doaj.org/article/f157f1f6af1543a581a38987f14888ea
Publikováno v:
PLoS Genetics, Vol 17, Iss 12, p e1009958 (2021)
Cell competition is a context-dependent cell elimination via cell-cell interaction whereby unfit cells ('losers') are eliminated from the tissue when confronted with fitter cells ('winners'). Despite extensive studies, the mechanism that drives loser
Externí odkaz:
https://doaj.org/article/3b3e2d954b104c4695a3dc42366b29e1
Publikováno v:
PLoS Genetics, Vol 17, Iss 11, p e1009893 (2021)
Identifying a common oncogenesis pathway among tumors with different oncogenic mutations is critical for developing anti-cancer strategies. Here, we performed transcriptome analyses on two different models of Drosophila malignant tumors caused by Ras
Externí odkaz:
https://doaj.org/article/63f3693295c84c8db7c87e355649fd66
Publikováno v:
PLoS Genetics, Vol 17, Iss 1, p e1009300 (2021)
Highly reproducible tissue development is achieved by robust, time-dependent coordination of cell proliferation and cell death. To study the mechanisms underlying robust tissue growth, we analyzed the developmental process of wing imaginal discs in D
Externí odkaz:
https://doaj.org/article/a2b2a9e9cd96443b9c80a4d185ea9b7c
