Výsledky vyhledávání - "Tatsuro Yasukata"

Practical Synthetic Method for the Preparation of Pyrone Diesters: An Efficient Synthetic Route for the Synthesis of Dolutegravir Sodium

Autor: Naoki Miyake, You Adachi, Yoshihide Sugata, Fumiya Ikarashi, Shin-Ichiro Hara, Yukihito Sumino, Kazuya Okamoto, Tatsuro Yasukata, Moriyasu Masui, Takanori Kurita, Masahiko Nagai

Publikováno v: Organic Process Research & Development. 23:565-570

A highly efficient and practical synthetic method for the preparation of pyrone diesters was established. The pyrone diester 3c can be prepared from readily available starting materials on a multihundred gram scale. The pyrone diester 3c can easily b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::844d013446226352b398a9225357ba35
https://doi.org/10.1021/acs.oprd.8b00410

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9-Oxime-3-ketolides: Modification at the C-11,12-diol moiety and antibacterial activities against key respiratory pathogens

Autor: Yukitoshi Narukawa, Takashi Nomura, Kouichi Uotani, Tatsuro Yasukata

Publikováno v: Bioorganic & Medicinal Chemistry. 13:6054-6063

In the search for new types of ketolide antibiotics active against key respiratory pathogens including erythromycin-resistant strains, we conducted an extensive study on the modification at the C-11,12-diol moiety of 9-oxime-3-ketolide derivatives. A

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfa793c3244ddae3066adf39ef7660ac
https://doi.org/10.1016/j.bmc.2005.06.003

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Practical Synthesis of Ethyl 1-(tert-Butoxycarbonyl)-4-(1-pyrrolidinyl)-4-piperidineacetate, an Intermediate of a Novel Antiarteriosclerotic, Utilizing Aza-Michael Addition Promoted by LiBr

Autor: Tatsuro Yasukata, Akira Iida, Naohiro Onodera

Publikováno v: Chemistry Letters. 41:1703-1705

The aza-Michael addition of pyrrolidine to β,β-dialkylated unsaturated ester 6 utilizing LiBr proceeded smoothly to give the inaccessible ethyl 1-(tert-butoxycarbonyl)-4-(1-pyrrolidinyl)-4-piperidi...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::51f46896d98bbfbce79f95fae8876ade
https://doi.org/10.1246/cl.2012.1703

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An efficient and practical method for solid-phase synthesis of tripeptide-bearing glycopeptide antibiotics: combinatorial parallel synthesis of carboxamide derivatives of chloroorienticin B

Autor: Tatsuro Yasukata, Yukihito Sumino, Hirohisa Shindo, Tadashi Munekage, Yasuhiro Nishitani, Osamu Yoshida, Yukitoshi Narukawa

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 12:3033-3036

An efficient and practical method was established for solid-phase parallel synthesis of the peptide-bearing carboxamide derivatives of chloroorienticin B, and over 80 compounds were synthesized simultaneously. Among the derivatives prepared, compound

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::655301f66539dc0eeaee950469e8b38f
https://doi.org/10.1016/s0960-894x(02)00665-0

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Novel semi-synthetic glycopeptide antibiotics active against methicillin-resistant staphylococcus aureus (MRSA) and vancomycin-resistant Enterococci (VRE): doubly-modified water-soluble derivatives of chloroorienticin B

Autor: Yasuhiro Nishitani, Tatsuro Yasukata, Yukitoshi Narukawa, Tadashi Munekage, Osamu Yoshida, Yukihito Sumino

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 12:3027-3031

A series of N-alkylated and aminomethylated derivatives of chloroorienticin B, a vancomycin-related glycopeptide antibiotic, were synthesized. Doubly-modified derivatives having both hydrophobic and hydrophilic substituents exhibited potent antibacte

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21a28f5f4a69d957ab279df432d737d0
https://doi.org/10.1016/s0960-894x(02)00664-9

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A mild method for the synthesis of carbamate-protected guanidines using the Burgess reagent

Autor: Tatsuro Yasukata, Toshikatsu Maki, Takayuki Tsuritani

Publikováno v: Organic letters. 16(7)

A simple method for the synthesis of carbamate-protected guanidines from primary amines is described. A variety of thioureas derived from primary amines and isothiocyanates react with the Burgess reagent to give the corresponding guanidines via eithe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::079f7e8347b361f4cd99beabf7db65e7
https://pubmed.ncbi.nlm.nih.gov/24628041

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Stereoselective reactions. 30. Enantioselective alkylation of the lithium enolates of six-membered cyclic ketones using tetradentate chiral amines in the presence of lithium bromide

Autor: Kenji Koga, Tatsuro Yasukata, Masatoshi Murakata, Makoto Nakajima, Takumi Aoki

Publikováno v: Tetrahedron. 54:2449-2458

An efficient enantioselective alkylation of the lithium enolates of cyclohexanone and I-tetralone with reactive alkyl halides was realized using a stoichiometric amount of a tetradentate chiral amine as a ligand for the lithium in the presence of lit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::005062a8ed6b22076838c3fb0cf3e9cd
https://doi.org/10.1016/s0040-4020(98)00009-x

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ChemInform Abstract: Practical Synthesis of Ethyl 1-(tert-Butoxycarbonyl)-4-(1-pyrrolidinyl)-4-piperidineacetate, an Intermediate of a Novel Antiarteriosclerotic, Utilizing Aza-Michael Addition Promoted by LiBr

Autor: Naohiro Onodera, Akira Iida, Tatsuro Yasukata

Publikováno v: ChemInform. 44

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::95c450bd26776247a19031200b8c2e14
https://doi.org/10.1002/chin.201320166

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