Zobrazeno 1 - 10
of 319
pro vyhledávání: '"Tatsuro Irimura"'
Autor:
Dong-hee Lee, Hyejin Ahn, Hye-In Sim, Eunji Choi, Seunghyun Choi, Yunju Jo, Bohwan Yun, Hyun Kyu Song, Soo Jin Oh, Kaori Denda-Nagai, Chan-Sik Park, Tatsuro Irimura, Yoon Park, Hyung-seung Jin
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 42, Iss 1, Pp 1-19 (2023)
Abstract Background Immunotherapy has significantly advanced cancer treatments, but many patients do not respond to it, partly due to immunosuppressive mechanisms used by tumor cells. These cells employ immunosuppressive ligands to evade detection an
Externí odkaz:
https://doaj.org/article/5a2155d0c9c541b7b2a52446c3747bb0
Autor:
Jia Shi, Yoshiki Onuki, Fumiya Kawanami, Naoko Miyagawa, Fumika Iwasaki, Haruna Tsuda, Katsuhiko Takahashi, Teruaki Oku, Masato Suzuki, Kyohei Higashi, Hayamitsu Adachi, Yoshio Nishimura, Motowo Nakajima, Tatsuro Irimura, Nobuaki Higashi
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 11, p 6281 (2024)
Mast cells take up extracellular latent heparanase and store it in secretory granules. The present study examined whether the enzymatic activity of heparanase regulates its uptake efficiency. Recombinant mouse heparanase mimicking both the latent and
Externí odkaz:
https://doaj.org/article/969785a10c96412f93cbc06015cace4e
Autor:
Ryoko Semba, Yoshiya Horimoto, Madoka Sakata-Matsuzawa, Yumiko Ishizuka, Kaori Denda-Nagai, Haruhiko Fujihira, Miki Noji, Hiroko Onagi, Miyu Ichida, Hiroyoshi Miura, Junichiro Watanabe, Mitsue Saito, Tsuyoshi Saito, Atsushi Arakawa, Tatsuro Irimura
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-8 (2023)
Abstract Adjuvant chemotherapy has played a major role in the treatment of hormone receptor-positive breast cancer for many years. To better determine which patient subsets need adjuvant chemotherapy, various gene expression analyses have been develo
Externí odkaz:
https://doaj.org/article/51c113899eb64465b13da15eeda32dc1
Autor:
Yuan Tian, Kaori Denda-Nagai, Tatsuya Tsukui, Katrin B. Ishii-Schrade, Kyoko Okada, Yoshihiro Nishizono, Kosuke Matsuzaki, Margarete Hafley, Robert S. Bresalier, Tatsuro Irimura
Publikováno v:
Cell Death Discovery, Vol 8, Iss 1, Pp 1-12 (2022)
Mucin 21 (MUC21) is a large glycoprotein that protects squamous epithelia. Glycan changes in mucins occur in cancer cells and are thought to contribute to malignant progression. We report glycoform-dependent antiapoptotic effects of MUC21. Various MU
Externí odkaz:
https://doaj.org/article/9d3957fb86f644c58a355f9ba11de2c5
Autor:
May Thinzar Hlaing, Yoshiya Horimoto, Kaori Denda-Nagai, Haruhiko Fujihira, Miki Noji, Hiroyuki Kaji, Azusa Tomioka, Yumiko Ishizuka, Harumi Saeki, Atsushi Arakawa, Mitsue Saito, Tatsuro Irimura
Publikováno v:
PLoS ONE, Vol 17, Iss 8, p e0273513 (2022)
Glycosylation is one of the most important post-translational modifications of cell surface proteins involved in the proliferation, metastasis and treatment resistance of cancer cells. However, little is known about the role of glycosylation as the m
Externí odkaz:
https://doaj.org/article/32aac742744a4c26a2281e666dc0f548
Autor:
Ryoka Kokubu, Shiho Ohno, Hirohide Kuratani, Yuka Takahashi, Noriyoshi Manabe, Hiroki Shimizu, Yasunori Chiba, Kaori Denda-Nagai, Makoto Tsuiji, Tatsuro Irimura, Yoshiki Yamaguchi
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 14, p 7855 (2022)
Anti-mucin1 (MUC1) antibodies have been widely used for breast cancer diagnosis and treatment. This is based on the fact that MUC1 undergoes aberrant glycosylation upon cancer progression, and anti-MUC1 antibodies differentiate changes in glycan stru
Externí odkaz:
https://doaj.org/article/aaf81c5a632342949076f580a1f6d5ea
Autor:
Jun Nishida, Shigeyuki Shichino, Tatsuya Tsukui, Mayumi Hoshino, Tomoko Okada, Kyoko Okada, Yuri Yi, Seiko Toraya-Brown, Miho Mochizuki, Ryouta Koizumi, Katrin Ishii-Schrade, Kaori Denda-Nagai, Tatsuro Irimura
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 12, p 6718 (2022)
Mucin 21(Muc21)/epiglycanin is expressed on apical surfaces of squamous epithelia and has potentially protective roles, which are thought to be associated with its unique glycoforms, whereas its aberrant glycosylation is implicated in the malignant b
Externí odkaz:
https://doaj.org/article/0c7712fb04f54d849118726e335adb41
Autor:
Madoka Sakata-Matsuzawa, Kaori Denda-Nagai, Haruhiko Fujihira, Miki Noji, Katrin Beate Ishii-Schrade, Atsushi Matsuda, Atsushi Kuno, Misato Okazaki, Katsuya Nakai, Yoshiya Horimoto, Mitsue Saito, Tatsuro Irimura
Publikováno v:
PLoS ONE, Vol 16, Iss 5, p e0250747 (2021)
IntroductionMolecular and cellular characteristics of the relapse-prone subset within triple-negative breast cancer (TNBC) remain unclear. Aberrant glycosylation is involved in the malignant behavior of cancer cells. In the present study, we aimed to
Externí odkaz:
https://doaj.org/article/d80271d4fbb04df1b52645110c17be3e
Autor:
Jia Shi, Riku Kanoya, Yurina Tani, Sodai Ishikawa, Rino Maeda, Sana Suzuki, Fumiya Kawanami, Naoko Miyagawa, Katsuhiko Takahashi, Teruaki Oku, Ami Yamamoto, Kaori Fukuzawa, Motowo Nakajima, Tatsuro Irimura, Nobuaki Higashi
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 9, p 5055 (2022)
We examined whether sulfated hyaluronan exerts inhibitory effects on enzymatic and biological actions of heparanase, a sole endo-beta-glucuronidase implicated in cancer malignancy and inflammation. Degradation of heparan sulfate by human and mouse he
Externí odkaz:
https://doaj.org/article/7e8232e06e8d45bf95cc9c116e62a055
Publikováno v:
Molecules, Vol 26, Iss 19, p 5962 (2021)
The role of sialic acids on MUC1 in peritoneal dissemination of ovarian cancer cells was investigated. A human ovarian carcinoma cell line, ES-2, was transfected with full-length MUC1 containing 22 or 42 tandem repeats. These transfectants were less
Externí odkaz:
https://doaj.org/article/c70e0b8395f348d0949d7a1cc3697f4f