Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Tatsuo Nunoshiba"'
Publikováno v:
Biochemical and biophysical research communications. 554
Under natural conditions, plants are exposed to solar ultraviolet (UV) radiation, which damages chromosomal DNA. Although plant responses to UV-induced DNA damage have recently been elucidated in detail, revealing a set of DNA repair mechanisms and t
Publikováno v:
Molecular Genetics and Genomics. 293:277-291
Markerless gene-disruption technology is particularly useful for effective genetic analyses of Thermus thermophilus (T. thermophilus), which have a limited number of selectable markers. In an attempt to develop a novel system for the markerless disru
Autor:
Tatsuo Nunoshiba, Keiichiro Hiratsu, Kazune Ezaki, Yuki Kato, Yoichiro Togawa, Shiori Shiotani
Publikováno v:
Molecular genetics and genomics : MGG. 294(4)
Thermus thermophilus (T. thermophilus) HB27 is an extreme thermophile that grows optimally at 65–72 °C. Heat-induced DNA lesions are expected to occur at a higher frequency in the genome of T. thermophilus than in those of mesophiles; however, the
Autor:
Sakae Arimoto, Keinosuke Okamoto, Akiyoshi Nishikawa, Masakuni Degawa, Kiyomitsu Nemoto, Tomoe Negishi, Xing Fang, Midori Yoshida, Tatsuo Nunoshiba, Eizo Takahashi
Publikováno v:
Genes and Environment. 36(1):1-9
It remains uncertain why non-genotoxic compounds that result in liver hypertrophy cause liver tumors. In an effort to resolve this issue, we examined whether liver post-mitochondrial fraction (S9) prepared from rats treated with non-genotoxic compoun
Construction of a supF-based system for detection of mutations in the chromosomal DNA of Arabidopsis
Publikováno v:
Molecular Genetics and Genomics. 288:707-715
The factors maintaining genomic integrity, which have been studied in detail in other species, have yet to be investigated in plants. Recent progress in gene-silencing technology has made it possible to produce transgenic plants with loss-of-function
Publikováno v:
FEBS Journal. 275:5733-5744
Recently, we have shown that phenyl hydroquinone, a hepatic metabolite of the Ames test-negative carcinogen o-phenylphenol, efficiently induced aneuploidy in Saccharomyces cerevisiae. We further found that phenyl hydroquinone arrested the cell cycle
Autor:
Chieko Ishiguro, Tatsuo Nunoshiba, Hideyoshi Harashima, Hiroshi Kasai, Kazuo Yamamoto, Mika Hori, Hiroyuki Kamiya, Noriko Nakagawa, Seiki Kuramitsu, Tetsuya Suzuki
Publikováno v:
DNA Repair. 6(12):1786-1793
Oxidatively damaged DNA precursors (deoxyribonucleotides) are formed by reactive oxygen species. After the damaged DNA precursors are incorporated into DNA, they might be removed by DNA repair enzymes. In this study, to examine whether a nucleotide e
Autor:
Ayako Ui, Teruhisa Takahashi, Yasukazu Daigaku, Tatsuo Nunoshiba, Takemi Enomoto, Kazuo Yamamoto, Satoko Ishikawa, Eri Watanabe, Masataka Mochizuki
Publikováno v:
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. 617:90-97
Ortho-phenyl phenol (OPP) is broad-spectrum of fungicides and antibacterial agents. OPP tested negative in an Ames system and positive with respect to the formation of tumors in the urinary bladder in rats when administered in diet, showing attribute
Autor:
Yu-ichiro Tago, Gaku Ohnishi, Yuki Nagata, Kazuo Yamamoto, Tatsuo Nunoshiba, Masaru Imai, Kingo Endo
Publikováno v:
Genes and Environment. 28:9-15
In this article, we described the spontaneously occurring mutation specificities of defects that are involved in translesion polymerase, mutS mismatch correction and polA mismatch correction in Escherichia coli. We argue that 1) there is no contribut
Publikováno v:
Biochemical and Biophysical Research Communications. 306:570-576
Damage to DNA by reactive oxygen species may be a significant source of endogenous mutagenesis in aerobic organisms. Using an endogenous tonB gene as a mutation selective marker in Escherichia coli, we have examined whether endogenous oxidative mutag