Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Tatsuo Kawashima"'
Autor:
Yasuo Matsuzawa, Yoshiaki Kiuchi, Kaori Toyomura, Ikiru Matsumoto, Hiroyuki Nakamura, Hiromichi Fujino, Toshihiko Murayama, Tatsuo Kawashima
Publikováno v:
Journal of Pharmacological Sciences, Vol 111, Iss 2, Pp 182-192 (2009)
In several types of cancer cells, prostaglandins produced via the over-expression of epidermal growth factor receptor (EGFR) and cyclooxygenases regulate cell growth. We investigated the signaling mechanisms for the release of arachidonic acid (AA, a
Externí odkaz:
https://doaj.org/article/2702cc8711d34578aa490011b9d7bc42
Autor:
Takashi Orido, Hiromichi Fujino, Yuta Hasegawa, Kaori Toyomura, Tatsuo Kawashima, Toshihiko Murayama
Publikováno v:
Journal of Pharmacological Sciences, Vol 108, Iss 3, Pp 389-392 (2008)
Nonsteroidal anti-inflammatory drugs (NSAIDs) reduce the incidence of colorectal cancer. However, evidence is accumulating that NSAIDs have anti-cancer effects in addition to inhibiting cyclooxygenase (COX)-mediated prostanoid biosynthesis. We now sh
Externí odkaz:
https://doaj.org/article/47102bfdf30e4371949e9d1df1741f85
Autor:
Tatsuo Kawashima, Yukiko Ishikura
Publikováno v:
International Higher Education. :25-27
Higher education institutions have undergone significant changes concerning college admissions. Leading countries for higher education, such as the United Kingdom and the United States, as well as countries in Asia such as China, Korea, and Taiwan ar
Autor:
Sho Otake, Tatsuo Kawashima, Risa Yamazaki, Yuta Ikawa, Hiroyuki Nakamura, Erika Yamaura, Yasuo Matsuzawa, Mamoru Takabatake, Hiromichi Fujino, Toshihiko Murayama
Publikováno v:
European Journal of Pharmacology. 696:120-129
Transforming growth factor-β1 (TGFβ1) plays a pivotal role in fibrosis in various organs including the lung. Following pulmonary injury, TGFβ1 stimulates conversion of fibroblasts to myofibroblasts that are mainly characterized by up-regulation of
Publikováno v:
Biochemical Pharmacology. 82:1781-1791
Levels of cyclooxygenase (COX)-2 and its metabolite prostaglandin E(2) (PGE(2)) are frequently increased in colon cancer and other cancers including lung cancer. Non-steroidal anti-inflammatory drugs are considered to have chemo-preventive effects on
Autor:
Koji Shirai, Yuichi Kouyama, Satoshi Muto, Yasuo Matsuzawa, Yuusaku Yokoyama, Tatsuo Kawashima, Toshihiro Ishii, Toru Masaka, Hiroaki Okuno
Publikováno v:
Biological and Pharmaceutical Bulletin. 34:562-566
Taxanes, which are widely used in treatment of numerous cancer types, are well-known to induce hypersensitivity reactions (HSR), especially in the case of paclitaxel. Although the cause of the HSR is commonly thought to be a non-immunological direct
Autor:
Tomohiko Makiyama, Toshihiko Murayama, Yasuo Matsuzawa, Erika Yamaura, Tatsuo Kawashima, Risa Yamazaki, Hiromichi Fujino
Publikováno v:
The Journal of Toxicological Sciences. 36:733-740
Excessive production of transforming growth factor-β1 (TGFβ1) plays an important role in lung fibrosis, in which the differentiation of fibroblasts into myofibroblasts is a key process. Increased formation of reactive oxygen species (ROS) induced b
Autor:
Yasuo Matsuzawa, Toshihisa Kuroda, Tatsuo Kawashima, Toru Wakabayashi, Kohji Shirai, Toshio Nishide
Publikováno v:
Respirology. 15:1261-1265
Pulmonary fibrosis associated with amyopathic dermatomyositis is known to have a generally aggressive course and is ultimately fatal. We report the case of a 50-year-old patient with amyopathic dermatomyositis, who developed progressive interstitial
Publikováno v:
Archives of Biochemistry and Biophysics. 494:78-85
Nonsteroidal anti-inflammatory drugs (NSAIDs) have chemopreventive activity and may be suitable for treatment of colorectal cancer. A popular and potent NSAID, indomethacin, is known to cause serious side-effects, for this reason its therapeutic usef
Autor:
Hiroyuki Nakamura, Takeshi Kurosawa, Tatsuo Kawashima, Hiromichi Fujino, Erika Yamaura, Toshihiko Murayama, Yasuo Matsuzawa
Publikováno v:
Journal of Cellular Physiology. 219:606-616
The thioredoxin (Trx) system, comprising Trx, the selenoprotein thioredoxin reductase (TrxR), and NADPH, functions as an antioxidant system. Trx has various biological activities including growth control and anti-apoptotic properties, and the Trx sys