Výsledky vyhledávání - "Tatsuo Furuyama"

Akademický článek

Macrophages play a crucial role in vascular smooth muscle cell coverage.

Autor: Niimi, Kenta, Nakae, Jun, Yoshiaki Kubota, Shinobu Inagaki, Tatsuo Furuyama

Publikováno v: Development (09501991); Sep2024, Vol. 151 Issue 18, p1-15, 15p

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Endothelial specific deletion of FOXO1 alters pericyte coverage in the developing retina

Autor: Yumi Adachi, Hiroko Ishikawa, Yoshiaki Kubota, Wataru Yamaguchi, Kenta Niimi, Shinobu Inagaki, Tatsuo Furuyama

Publikováno v: Biochemical and Biophysical Research Communications. 520:304-310

Pericytes are mural cells that cover small blood vessels. While defects in pericyte coverage are known to be involved in various vessel related pathologies, including diabetic retinopathy, the molecular mechanisms underlying pericyte coverage are not

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f86f679eafb449b791c13e664884fd78
https://doi.org/10.1016/j.bbrc.2019.10.040

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FOXO1 represses lymphatic valve formation and maintenance via PRDM1

Autor: Tatsuo Furuyama, Shinobu Inagaki, Kenta Niimi, Jun Nakae

Publikováno v: Cell Reports. 37:110048

Summary Intraluminal lymphatic valves (LVs) contribute to the prevention of lymph backflow and maintain circulatory homeostasis. Several reports have investigated the molecular mechanisms which promote LV formation; however, the way in which they are

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db1a7b999d0b30213e2f6b30605ffd5b
https://doi.org/10.1016/j.celrep.2021.110048

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Tip-cell behavior is regulated by transcription factor FoxO1 under hypoxic conditions in developing mouse retinas

Autor: Jun-ichi Miyazaki, Moe Fukumoto, Fumi Tashiro, Mikiko Hayashi, Kazumasa Uni, Kanako Kondo, Shinobu Inagaki, Satsuki Miyazaki, Kenta Niimi, Tomoko Ishiguro, Itsuki Mori, Shinnosuke Ueda, Tatsuo Furuyama

Publikováno v: Angiogenesis. 21:203-214

Forkhead box protein O1 (FoxO1) is a transcription factor and a critical regulator of angiogenesis. Various environmental stimuli, including growth factors, nutrients, shear stress, oxidative stress and hypoxia, affect FoxO1 subcellular localization

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2440ae8ebd79678e47772bb19aed0abb
https://doi.org/10.1007/s10456-017-9588-z

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Upregulation of IFN-β induced by Sema4D-dependent partial Erk1/2 inhibition promotes NO production in microglia

Autor: Natsumi Yamaguchi, Satoshi Shibata, Hidekazu Tanaka, Tatsuo Furuyama, Fumiya Watanabe, Wataru Yamaguchi, Shinobu Inagaki, Ryo Tsuchihashi, Kenta Niimi, Toshinori Sawano

Publikováno v: Biochemical and biophysical research communications. 521(4)

Interactions between Sema4D and its receptors, PlexinB1 and CD72, induce various functions, including axon guidance, angiogenesis, and immune activation. Our previous study revealed that Sema4D is involved in the upregulation of nitric oxide producti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0af28833fcbc22d7b46322243254a65
https://pubmed.ncbi.nlm.nih.gov/31708102

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FOXO1 regulates developmental lymphangiogenesis by upregulating CXCR4 in the mouse-tail dermis

Autor: Satoshi Shibata, Toshinori Sawano, Misaki Kohara, Eriko Sedoh, Yoshiaki Kubota, Fumi Tashiro, Jun-ichi Miyazaki, Tatsuo Furuyama, Shinobu Inagaki, Moe Fukumoto, Satsuki Miyazaki, Kenta Niimi

Publikováno v: Development (Cambridge, England). 147(2)

Lymphangiogenesis plays important roles in normal fetal development and postnatal growth. However, its molecular regulation remains unclear. Here, we examined the function of forkhead box protein O1 (FOXO1) transcription factor, a known angiogenic fa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef5bdf6de51ee00aa344c5343f92c88f
https://pubmed.ncbi.nlm.nih.gov/31852686

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Changes in L-arginine metabolism by Sema4D deficiency induce promotion of microglial proliferation in ischemic cortex

Autor: Toshinori Sawano, Natsumi Yamaguchi, Tatsuo Furuyama, Fumiya Watanabe, Hidekazu Tanaka, Kenta Niimi, Wataru Yamaguchi, Tomohiro Matsuyama, Shinobu Inagaki, Ryo Tsuchihashi

Publikováno v: Neuroscience. 406

Cerebral ischemia induces neuroinflammation and microglial activation, in which activated microglia upregulate their proliferative activity and change their metabolic states. In activated microglia, l-arginine is metabolized competitively by inducibl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86a319a4a595c898589b5e0657e961b9
https://pubmed.ncbi.nlm.nih.gov/30922994

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