Polymorphism in autophagy-related genes LRP1 and CAPZA1 may promote gastric mucosal atrophy

Autor: Naoyuki Yamaguchi, Takuki Sakaguchi, Hajime Isomoto, Tatsuo Inamine, Ryoya Tsukamoto, Daisuke Fukuda, Ken Ohnita, Tsutomu Kanda, Kayoko Matsushima, Tatsuro Hirayama, Kazuo Yashima, Kazuhiro Tsukamoto

Publikováno v: Genes and Environment, Vol 45, Iss 1, Pp 1-12 (2023)

Abstract Background Helicobacter pylori secretes cytotoxin-associated gene A (CagA) into the gastric epithelium, causing gastric mucosal atrophy (GMA) and gastric cancer. In contrast, host cells degrade CagA via autophagy. However, the association be

Externí odkaz: https://doaj.org/article/65ab2363fdba4ee4979aed01735e44de

Gastric acid suppression promotes alcoholic liver disease by inducing overgrowth of intestinal Enterococcus

Autor: Cristina Llorente, Peter Jepsen, Tatsuo Inamine, Lirui Wang, Sena Bluemel, Hui J. Wang, Rohit Loomba, Jasmohan S. Bajaj, Mitchell L. Schubert, Masoumeh Sikaroodi, Patrick M. Gillevet, Jun Xu, Tatiana Kisseleva, Samuel B. Ho, Jessica DePew, Xin Du, Henrik T. Sørensen, Hendrik Vilstrup, Karen E. Nelson, David A. Brenner, Derrick E. Fouts, Bernd Schnabl

Publikováno v: Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)

Proton pump inhibitors (PPIs) reduce gastric acid secretion and modulate gut microbiota composition. Here Llorente et al. show that PPIs induce bacterial overgrowth of enterococci, which, in turn, exacerbate ethanol-induced liver disease both in mice

Externí odkaz: https://doaj.org/article/27b348ac046b489ebb905be4e8fb371a

Letrozole ameliorates liver fibrosis through the inhibition of the CTGF pathway and 17β-hydroxysteroid dehydrogenase 13 expression

Autor: Norihiro Sakai, Kenya Kamimura, Hirotaka Miyamoto, Masayoshi Ko, Takuro Nagoya, Toru Setsu, Akira Sakamaki, Takeshi Yokoo, Hiroteru Kamimura, Hiroyuki Soki, Ayako Tokunaga, Tatsuo Inamine, Mikiro Nakashima, Hatsune Enomoto, Kazuki Kousaka, Hidehisa Tachiki, Kaname Ohyama, Shuji Terai

Publikováno v: Journal of gastroenterology. 58(1)

To establish a treatment option for liver fibrosis, the possibility of the drug repurposing theory was investigated, with a focus on the off-target effects of active pharmaceutical ingredients.First, several active pharmaceutical ingredients were scr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3acd7c77a8a4df5900568215dd826a3a
https://pubmed.ncbi.nlm.nih.gov/36301364

Synthesis of high functionality and quality mannose-grafted lipids to produce macrophage-targeted liposomes

Autor: Shigeru Kawakami, Tadaharu Suga, Yorinao Chinda, Tatsuo Inamine, Masayori Hagimori, Yuki Fuchigami, Naoya Kato, Kazuto Yamanami

Publikováno v: European Journal of Pharmaceutical Sciences. 123:153-161

The mannose receptor, which is responsible for tumor invasion, proliferation, and metastasis in the tumor microenvironment, is overexpressed in tumor-associated macrophages. Mannose is commonly applied to PEGylated liposomes in macrophage-targeted ca

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23c73d6e5d97c7729b260fcee9209175
https://doi.org/10.1016/j.ejps.2018.07.036

Intestinal iNKT cells migrate to liver and contribute to hepatocyte apoptosis during alcoholic liver disease

Autor: Igor Maricic, Han-Chieh Lin, Rohit Loomba, Vipin Kumar, Peng Chen, Peter Stärkel, Suryasarathi Dasgupta, Tatsuo Inamine, Bernd Schnabl, Julia C. Sun, Shenhai Gong, Jingjuan Hu, Yi Tsung Lin, Kuei Chuan Lee

Publikováno v: American journal of physiology. Gastrointestinal and liver physiology, Vol. 316, no. 5, p. G585-G597 (2019)
Am J Physiol Gastrointest Liver Physiol

We investigated the migration of intestinal immune cells to the liver and their contribution to alcoholic liver disease. In mice fed ethanol, we found that an increased number of invariant natural killer T (iNKT) cells, which respond to the antigen p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d33a19c23ff4b3844378daf9553f52ad
https://hdl.handle.net/2078.1/230932