Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Tatsuo, Shiba"'
Publikováno v:
Journal of Pharmacological Sciences, Vol 131, Iss 3, Pp 162-171 (2016)
Thrombin-activated protease-activated receptor (PAR)-1 regulates the proliferation of neural cells following brain injury. To elucidate the involvement of PAR-1 in the neurogenesis that occurs in the adult hippocampus, we examined whether PAR-1 regul
Externí odkaz:
https://doaj.org/article/14344a5454c74452b655d955a3713cd8
Autor:
Masanori Yoneyama, Shigeru Hasebe, Noriko Kawamoto, Tatsuo Shiba, Taro Yamaguchi, Maho Kikuta, Makoto Shuto, Kiyokazu Ogita
Publikováno v:
Journal of Pharmacological Sciences, Vol 124, Iss 1, Pp 99-111 (2014)
Abstract.: Aripiprazole is used clinically as an atypical antipsychotic. We evaluated the effect of in vivo treatment with aripiprazole on the proliferation and differentiation of neural stem/progenitor cells in a mouse model, trimethyltin-induced ne
Externí odkaz:
https://doaj.org/article/d1d7bfe69b2f458e826f76d2b6177518
Autor:
Maho Kikuta, Tatsuo Shiba, Masanori Yoneyama, Koichi Kawada, Taro Yamaguchi, Eiichi Hinoi, Yukio Yoneda, Kiyokazu Ogita
Publikováno v:
Journal of Pharmacological Sciences, Vol 121, Iss 1, Pp 74-83 (2013)
Edaravone is clinically used in Japan for treatment of patients with acute cerebral infarction. To clarify the effect of edaravone on neurogenesis in the hippocampus following neuronal injury in the hippocampal dentate gyrus, we investigated the effe
Externí odkaz:
https://doaj.org/article/5e173d0bcf7c4958bc135c3843efea7e
Publikováno v:
Journal of Pharmacological Sciences, Vol 115, Iss 4, Pp 425-432 (2011)
Adult neurogenesis is the process of generating new neurons that become integrated into existing circuits after fetal and early postnatal development has ceased. In most mammalian species, adult neurogenesis only appears to occur in the olfactory bul
Externí odkaz:
https://doaj.org/article/fa44d9aaf84c4384a6025f7fbe801555
Publikováno v:
Journal of Pharmacological Sciences, Vol 115, Iss 2, Pp 182-195 (2011)
Nitric oxide (NO) activates the cyclic GMP (cGMP) / protein kinase G (PKG) pathway during physiological processes in numerous types of cells. Here, we evaluated whether this NO/cGMP/PKG pathway is involved in the proliferation of neural stem/progenit
Externí odkaz:
https://doaj.org/article/afe4b40325684463834f53b494376fb8
Publikováno v:
Journal of Pharmacological Sciences, Vol 113, Iss 3, Pp 267-270 (2010)
We investigated the effects of treatment with trimethyltin (TMT) on the expression of glutathione-related enzymes in mouse hippocampus. TMT promoted the expression of glutathione S-transferase (GST) Ya/Yc mRNA, and GSTA2 protein, but not that of glut
Externí odkaz:
https://doaj.org/article/04917df48f354d7992e3d216e0bb3dfd
Publikováno v:
PLoS ONE, Vol 9, Iss 7, p e102133 (2014)
Noise-induced hearing loss is at least in part due to disruption of endocochlear potential, which is maintained by various K(+) transport apparatuses including Na(+), K(+)-ATPase and gap junction-mediated intercellular communication in the lateral wa
Externí odkaz:
https://doaj.org/article/2972883ba47c40ba8967e2b4950d1d53
Autor:
Masanori Yoneyama, Tatsuo Shiba, Shigeru Hasebe, Kasumi Umeda, Taro Yamaguchi, Kiyokazu Ogita
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e87953 (2014)
Lithium, a mood stabilizer, is known to ameliorate the stress-induced decrease in hippocampal neurogenesis seen in animal models of stress-related disorders. However, it is unclear whether lithium has beneficial effect on neuronal repair following ne
Externí odkaz:
https://doaj.org/article/dfcbe613673443668ef5b3364e840f95
Autor:
Atsuko Yokota, Naoko Tanaka-Totoribe, Shuji Gamoh, Takahiro Hayase, Masachika Kuwabara, Eisaku Nakamura, Kunihide Nakamura, Tatsuo Shiba, Ryuichi Yamamoto
Publikováno v:
Biological and Pharmaceutical Bulletin. 41:820-823
Studies indicate that 5-hydroxytryptamine (5-HT) released from activated platelets in coronary artery bypass grafting (CABG) induces 5-HT2A receptor-mediated graft spasm. We previously reported that 5-HT-induced constriction of human endothelium-denu
Publikováno v:
Clinical and experimental pharmacologyphysiology. 46(5)
Many hypertensive animal models have been developed and used to elucidate the pathophysiology of hypertension and to develop antihypertensive drugs. Among them, the spontaneous hypertensive rat (SHR), deoxycorticosterone acetate (DOCA)-treated and hi