Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Tatsuo, Oikawa"'
Autor:
Yuko Kokubu, Tomoko Nagino, Katsunori Sasa, Tatsuo Oikawa, Katsuya Miyake, Akiko Kume, Mikiko Fukuda, Hiromitsu Fuse, Ryuichi Tozawa, Hidetoshi Sakurai
Publikováno v:
Stem Cells Translational Medicine, Vol 8, Iss 10, Pp 1017-1029 (2019)
Abstract Dysferlinopathy is a progressive muscle disorder that includes limb‐girdle muscular dystrophy type 2B and Miyoshi myopathy (MM). It is caused by mutations in the dysferlin (DYSF) gene, whose function is to reseal the muscular membrane. Tre
Externí odkaz:
https://doaj.org/article/b07e2c3175334def8fbba6cc177a30d7
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
Abstract Purinergic P2Y 2 receptors, G-protein coupled receptors that primarily couple with Gαq/11-proteins, are activated equipotently by adenosine-5′-triphosphate (ATP) and uridine-5′-triphosphate. Evidence suggests that P2Y 2 agonists make po
Externí odkaz:
https://doaj.org/article/7318d80836ef4964a22fb41a3fcb7561
Autor:
Akiko Kume, Tomoko Nagino, Katsunori Sasa, Hidetoshi Sakurai, Katsuya Miyake, Mikiko Fukuda, Ryuichi Tozawa, Tatsuo Oikawa, Yuko Kokubu, Hiromitsu Fuse
Publikováno v:
Stem Cells Translational Medicine, Vol 8, Iss 10, Pp 1017-1029 (2019)
Stem Cells Translational Medicine
Stem Cells Translational Medicine
Dysferlinopathy is a progressive muscle disorder that includes limb-girdle muscular dystrophy type 2B and Miyoshi myopathy (MM). It is caused by mutations in the dysferlin (DYSF) gene, whose function is to reseal the muscular membrane. Treatment with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7628d2448d55c740864418d077b3ec33
https://doaj.org/article/b07e2c3175334def8fbba6cc177a30d7
https://doaj.org/article/b07e2c3175334def8fbba6cc177a30d7
Autor:
Akiko Oki, Katsunori Sasa, Hiroyuki Takada, Bunnai Saito, Kazumasa Miyamoto, Tomoko Nagino, Hidetoshi Sakurai, Ryuichi Tozawa, Tatsuo Oikawa, Makoto Miyamoto, Yuko Kokubu, Michiko Tawada, Tomoya Sameshima, Akira Kaieda
Publikováno v:
Journal of Medicinal Chemistry. 62:9175-9187
Dysferlinopathies, which are muscular diseases caused by mutations in the dysferlin gene, remain serious medical problems due to the lack of therapeutic agents. Herein, we report the design, synthesis, and structure-activity relationships of a 2,6-di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f9111b391e088e8dd74adcaa24e72217
https://doi.org/10.1021/acs.jmedchem.9b01100
https://doi.org/10.1021/acs.jmedchem.9b01100
Autor:
Yoshinori Satomi, Nobuyuki Amano, Takafumi Yukawa, Nobuyuki Matsunaga, Tatsuo Oikawa, Kazuki Kubo, Takashi Nakahata, Rei Okamoto, Yasufumi Miyamoto, Yuji Ishichi, Masahiro Kamaura, Satoshi Nishimura, Ryutaro Adachi, Masanori Nakakariya
Publikováno v:
Bioorganicmedicinal chemistry. 28(7)
Sphingomyelin synthase 2 (SMS2) has attracted attention as a drug target for the treatment of various cardiovascular and metabolic diseases. The modification of a high throughput screening hit, 2-quinolone 10, enhanced SMS2 inhibition at nanomolar co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79e0497fab2000ae15f8faf728f2454e
https://pubmed.ncbi.nlm.nih.gov/32088125
https://pubmed.ncbi.nlm.nih.gov/32088125
Autor:
Hiroyuki, Takada, Akira, Kaieda, Michiko, Tawada, Tomoko, Nagino, Katsunori, Sasa, Tatsuo, Oikawa, Akiko, Oki, Tomoya, Sameshima, Kazumasa, Miyamoto, Makoto, Miyamoto, Yuko, Kokubu, Ryuichi, Tozawa, Hidetoshi, Sakurai, Bunnai, Saito
Publikováno v:
Journal of medicinal chemistry. 62(20)
Dysferlinopathies, which are muscular diseases caused by mutations in the dysferlin gene, remain serious medical problems due to the lack of therapeutic agents. Herein, we report the design, synthesis, and structure-activity relationships of a 2,6-di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::bd17d6870974e86fdd2fb0361e89ead6
https://pubmed.ncbi.nlm.nih.gov/31550153
https://pubmed.ncbi.nlm.nih.gov/31550153
Autor:
Mika Teratani, Shuichi Takagahara, Takayuki Kamei, Yasushi Masuda, Sachiko Imaichi, Satoshi Nishimura, Shota Ikeda, Shumpei Murata, Tetsuya Ohtaki, Tatsuo Oikawa, Kenjo Eriya, Kenichi Miyata, Yukimasa Makita, Kentaro Otake, Tsukasa Sugo, Kuniko Kikuchi, Mari Ogasawara-Shimizu, Hirokazu Matsumoto, Michiko Terada
Publikováno v:
Journal of Controlled Release. 237:1-13
Despite considerable efforts to develop efficient carriers, the major target organ of short-interfering RNAs (siRNAs) remains limited to the liver. Expanding the application outside the liver is required to increase the value of siRNAs. Here we repor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::770877c18100230ec2099489deb318c7
https://doi.org/10.1016/j.jconrel.2016.06.036
https://doi.org/10.1016/j.jconrel.2016.06.036
Autor:
Naoki Kaneko, Masaru Okuda, Kazuhito Itamoto, Hisashi Inokuma, Tatsuo Oikawa, Hiroko Hiraoka, Malaika Watanabe, Takuya Mizuno
Publikováno v:
Veterinary Parasitology. 136(2):47-54
application/pdf
Three beagle dogs were inoculated with mice spleen/liver homogenate infected with Ehrlichia species detected from Ixodes ovatus (EIO) and one dog was used as a control. All three infected dogs did not show clinical signs of disea
Three beagle dogs were inoculated with mice spleen/liver homogenate infected with Ehrlichia species detected from Ixodes ovatus (EIO) and one dog was used as a control. All three infected dogs did not show clinical signs of disea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ef335189d8d4ba43f29f8ef321eaeb3
https://obihiro.repo.nii.ac.jp/records/411
https://obihiro.repo.nii.ac.jp/records/411
Autor:
Naoki Kaneko, Munekazu Nakaichi, Tatsuo Oikawa, Hisashi Inokuma, Hiroko Hiraoka, Kazuhito Itamoto, Masaru Okuda, Malaika Watanabe, Takuya Mizuno
Publikováno v:
Journal of Veterinary Medical Science. 68:297-301
Growth arrest and DNA damage-inducible protein 45 (GADD45) plays an important role in suppressing multistep carcinogenesis. In this report, we describe the isolation of the complete wild-type feline GADD45 cDNA from feline tissues. Expression of feli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ca7abaee59364c8e1e8dd26277fcc03
https://doi.org/10.1292/jvms.68.297
https://doi.org/10.1292/jvms.68.297
Autor:
Noriko Kanaya, Satoshi Une, Takafumi Onishi, Tatsuo Oikawa, Yasuho Taura, Masahiro Morimoto, Munekazu Nakaichi, Masaru Okuda, Naomi Toyama, Toshiharu Hayashi, Hisashi Inokuma, Hajime Tsujimoto
Publikováno v:
Journal of Veterinary Medical Science. 64:973-979
To detect the anti-P53 antibodies of dogs with tumors, a GST-recombinant canine (rc) P53 fusion protein was expressed and purified. Immunoblot analysis was performed using this GST-rcP53 fusion protein as an antigen and serum samples from dogs suffer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c3b99917661c7203047362d1f8f0d51
https://doi.org/10.1292/jvms.64.973
https://doi.org/10.1292/jvms.64.973