Zobrazeno 1 - 10
of 172
pro vyhledávání: '"Tatsuki, Fukami"'
Autor:
Koki Katayama, Shimon Nakashima, Hiroo Ishida, Yutaro Kubota, Masataka Nakano, Tatsuki Fukami, Yasutsuna Sasaki, Ken-ichi Fujita, Miki Nakajima
Publikováno v:
Non-coding RNA Research, Vol 6, Iss 3, Pp 123-129 (2021)
Single nucleotide polymorphisms in genes encoding microRNAs (miRNA-SNPs) may affect the maturation steps of miRNAs or target mRNA recognition, leading to changes in the expression of target mRNAs to cause gain- or loss-of-function changes. Several mi
Externí odkaz:
https://doaj.org/article/19faf567fce240339e0b270504a3c810
Publikováno v:
Journal of Pharmaceutical Sciences. 112:1671-1680
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::33a6f23ae6ee175269fc84d696262330
https://doi.org/10.1016/j.xphs.2023.01.025
https://doi.org/10.1016/j.xphs.2023.01.025
Autor:
Shogo Takahashi, Naoki Tanaka, Tatsuki Fukami, Cen Xie, Tomoki Yagai, Donghwan Kim, Thomas J. Velenosi, Tingting Yan, Kristopher W. Krausz, Moshe Levi, Frank J. Gonzalez
Publikováno v:
Hepatology Communications, Vol 2, Iss 12, Pp 1567-1582 (2018)
Hepatocellular carcinoma (HCC) is a leading cause of cancer deaths worldwide, and an association between altered bile acid (BA) metabolism, down‐regulation of farnesoid X receptor (FXR), which is a master regulator of BA metabolism, and hepatocarci
Externí odkaz:
https://doaj.org/article/dfa052a0f4e946dfaf779f784ef1f2a2
Autor:
Shimon Nakashima, Rei Sato, Tatsuki Fukami, Takashi Kudo, Shiori Hashiba, Gaku Morinaga, Masataka Nakano, Eva Ludwig-Schwellinger, Akiko Matsui, Naoki Ishiguro, Thomas Ebner, Miki Nakajima
Publikováno v:
Drug Metabolism and Disposition. 51:733-742
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::61a045703a9610ae155292aa06e51762
https://doi.org/10.1124/dmd.122.001113
https://doi.org/10.1124/dmd.122.001113
Cyp2c70 is responsible for the species difference in bile acid metabolism between mice and humans[S]
Autor:
Shogo Takahashi, Tatsuki Fukami, Yusuke Masuo, Chad N. Brocker, Cen Xie, Kristopher W. Krausz, C. Roland Wolf, Colin J. Henderson, Frank J. Gonzalez
Publikováno v:
Journal of Lipid Research, Vol 57, Iss 12, Pp 2130-2137 (2016)
Bile acids are synthesized from cholesterol in the liver and subjected to multiple metabolic biotransformations in hepatocytes, including oxidation by cytochromes P450 (CYPs) and conjugation with taurine, glycine, glucuronic acid, and sulfate. Mice a
Externí odkaz:
https://doaj.org/article/b492e5b921554905ba4d7d1bcb88606c
Autor:
Zheping Huang, Yu Li, Keigo Konishi, Yoshiyuki Sakai, Kiyomichi Tashiro, Tatsuki Fukami, Jimo Borjigin
Publikováno v:
Journal of Pineal Research.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::253ccd2277491020ac9a443491376b58
https://doi.org/10.1111/jpi.12870
https://doi.org/10.1111/jpi.12870
Autor:
Alfred H. Schinkel, Jos H. Beijnen, Bart J.M. van Vlijmen, Tsuyoshi Yokoi, Els Wagenaar, Selvi Durmus, Tatsuki Fukami, Ka Lei Cheung, Rolf W. Sparidans, Seng Chuan Tang
PDF file - 110KB, S1. Overview of the corresponding deltaCt values belonging to the RT-PCR results as shown in Supplementary Data 2. S2. Overview of the corresponding ΔCt values belonging to the RT-PCR results as shown in Figure 4. S3. Overview of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8384d7d06ad1ed51601b0184ecf9c414
https://doi.org/10.1158/1078-0432.22452147
https://doi.org/10.1158/1078-0432.22452147
Autor:
Alfred H. Schinkel, Jos H. Beijnen, Bart J.M. van Vlijmen, Tsuyoshi Yokoi, Els Wagenaar, Selvi Durmus, Tatsuki Fukami, Ka Lei Cheung, Rolf W. Sparidans, Seng Chuan Tang
PDF file - 117KB
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8521c99bbaa4e7418539b2d0498f7cf2
https://doi.org/10.1158/1078-0432.22452150.v1
https://doi.org/10.1158/1078-0432.22452150.v1
Autor:
Alfred H. Schinkel, Jos H. Beijnen, Bart J.M. van Vlijmen, Tsuyoshi Yokoi, Els Wagenaar, Selvi Durmus, Tatsuki Fukami, Ka Lei Cheung, Rolf W. Sparidans, Seng Chuan Tang
PDF file - 666KB, S1. Molecular structure of everolimus (A) and putative molecular structure of metabolite A (B). S2. 2. Liver expression of Ces1 and Ces2 genes in male wild-type, Abcb1a/1b(-/-), Abcg2(-/-) and Abcb1a/1b;Abcg2(-/-) mice. S3. Inhibito
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c68caac991e54449bb35751b7738675
https://doi.org/10.1158/1078-0432.22452153.v1
https://doi.org/10.1158/1078-0432.22452153.v1
Autor:
Alfred H. Schinkel, Jos H. Beijnen, Bart J.M. van Vlijmen, Tsuyoshi Yokoi, Els Wagenaar, Selvi Durmus, Tatsuki Fukami, Ka Lei Cheung, Rolf W. Sparidans, Seng Chuan Tang
Purpose: To clarify the role of ABCB1, ABCG2, and CYP3A in blood and brain exposure of everolimus using knockout mouse models.Experimental Design: We used wild-type, Abcb1a/1b−/−, Abcg2−/−, Abcb1a/1b;Abcg2−/−, and Cyp3a−/− mice to stu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93d60f8a357693a7b2f17b2d095a9749
https://doi.org/10.1158/1078-0432.c.6522396
https://doi.org/10.1158/1078-0432.c.6522396