Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Tatsuhiro Igawa"'
Publikováno v:
The Journal of Biochemistry. 169:491-496
P2X4 receptor is known to be involved in neuropathic pain. In order to detect the expression of P2X4 receptor on microglia at the time of onset of neuropathic pain, one approach consists on the preparation of the monoclonal antibodies with both selec
Autor:
Mutsuo Sekiguchi, Takashi Ishii, Tsugumi Fujita, Hiroshi Hayakawa, Yusaku Nakabeppu, Tatsuhiro Igawa
Publikováno v:
The Journal of Biological Chemistry
J Biol Chem
J Biol Chem
PCBP1, a member of the poly(C)-binding protein (PCBP) family, has the capability of binding heavily oxidized RNA and therefore participates in the cellular response to oxidative conditions, helping to induce apoptosis. There are four other members of
Autor:
Hidetoshi Tozaki-Saitoh, Tomohiro Yamashita, Saki Nagai, Chinatsu Shinozaki, Shuhei Kishikawa, Tadashi Ueda, Mitsunori Shiroishi, Hiroyuki Tanaka, Makoto Tsuda, Tatsuhiro Igawa, Kazuhide Inoue, Yoshito Abe
Publikováno v:
Purinergic Signalling. 15:27-35
P2X purinergic receptors are ATP-driven ionic channels expressed as trimers and showing various functions. A subtype, the P2X4 receptor present on microglial cells is highly involved in neuropathic pain. In this study, in order to prepare antibodies
Autor:
Takashi Ishii, Tatsuhiro Igawa, Hiroshi Hayakawa, Tsugumi Fujita, Mutsuo Sekiguchi, Yusaku Nakabeppu
Publikováno v:
Journal of Biological Chemistry. 297:101447
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 115(26)
In aerobically growing cells, the guanine base of RNA is oxidized to 8-oxo-7,8-dihydroguanine (8-oxoG), which induces alteration in their gene expression. We previously demonstrated that the human AUF1 protein binds to 8-oxoG in RNA to induce the sel
Autor:
Takashi Ishii1,2, Tatsuhiro Igawa3, Hiroshi Hayakawa1, Tsugumi Fujita1, Mutsuo Sekiguchi3, Yusaku Nakabeppu4 yusaku@bioreg.kyushu-u.ac.jp
Publikováno v:
Journal of Biological Chemistry. 8/21/2020, Vol. 295 Issue 34, p12247-12261. 15p.
Publikováno v:
FEBS letters. 589(6)
The P2X receptor is an ATP-gated cation channel expressed on the plasma membrane. The head domain (Gln111–Val167 in the rat P2X4 receptor) regulates ATP-induced cation influx. In this study, we prepared a head domain with three disulfide bonds, suc
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America; 6/26/2018, Vol. 115 Issue 26, p6715-6720, 6p
Autor:
Sadayuki Higashi, Hiroyuki Tanaka, Tadashi Ueda, Makoto Tsuda, Satoshi Morimoto, Yoshito Abe, Tatsuhiro Igawa, Kazuhide Inoue, Takatoshi Ohkuri, Tomohiro Yamashita
Publikováno v:
Journal of biochemistry. 153(3)
The P2X4 purinergic receptor is a key molecule in neuropathic pain, particularly in the allodynia after peripheral nerve injury. We therefore sought to establish an anti-P2X4 receptor monoclonal antibody that would be useful for detection and charact