Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Tatsuhiro Akaishi"'
Autor:
Hiroki Furuie, Yuka Kimura, Tatsuhiro Akaishi, Misa Yamada, Yoshiki Miyasaka, Akiyoshi Saitoh, Norihiro Shibuya, Akiko Watanabe, Naoki Kusunose, Tomoji Mashimo, Takeo Yoshikawa, Mitsuhiko Yamada, Kazuho Abe, Hideo Kimura
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-19 (2023)
Abstract Hydrogen sulfide (H2S) and polysulfides (H2Sn, n ≥ 2) are signaling molecules produced by 3-mercaptopyruvate sulfurtransferase (3MST) that play various physiological roles, including the induction of hippocampal long-term potentiation (LTP
Externí odkaz:
https://doaj.org/article/3d56f9cba1e54d54950d1bcef19a0edf
Publikováno v:
Journal of Pharmacological Sciences, Vol 136, Iss 1, Pp 42-45 (2018)
To explore memory enhancing effect of the flavonoid fisetin, we investigated the effect of oral administration of flavonoids on the induction of long-term potentiation (LTP) at hippocampal CA1 synapses of anesthetized rats. Among four flavonoids (fis
Externí odkaz:
https://doaj.org/article/27043c5733a844de9288627fc71b68f1
Publikováno v:
Journal of Pharmacological Sciences, Vol 115, Iss 2, Pp 254-257 (2011)
We compared the effects of the extract from fruits of Nandina domestica THUNBERG (NDE) and its constituents, higenamine and nantenine, on contractile responses in isolated guineapig trachea. NDE (1 mg/ml) caused biphasic relaxation of the trachea pre
Externí odkaz:
https://doaj.org/article/a392e5d036a34399a5b71c277d2fce78
Autor:
Qi Chen, Marguerite Prior, Richard Dargusch, Amanda Roberts, Roland Riek, Cédric Eichmann, Chandramouli Chiruta, Tatsuhiro Akaishi, Kazuho Abe, Pamela Maher, David Schubert
Publikováno v:
PLoS ONE, Vol 6, Iss 12, p e27865 (2011)
Currently, the major drug discovery paradigm for neurodegenerative diseases is based upon high affinity ligands for single disease-specific targets. For Alzheimer's disease (AD), the focus is the amyloid beta peptide (Aß) that mediates familial Alzh
Externí odkaz:
https://doaj.org/article/0a57350625464ea7ac60fc7fc33b8969
Publikováno v:
Biological and Pharmaceutical Bulletin. 45:301-308
Neuroinflammation induced by activated microglia is a key feature of neurodegenerative diseases such as Alzheimer's disease. The natural flavonoid 3',4',7-trihydroxyflavone protects nerve cells from oxidative stress-mediated apoptosis and inhibits th
Publikováno v:
Biological and Pharmaceutical Bulletin. 43:138-144
We have recently found that the synthetic curcumin derivative CNB-001 suppresses lipopolysaccharide (LPS)-induced nitric oxide (NO) production in cultured microglia, demonstrating that it exerts anti-neuroinflammatory effects by regulating microglial
Publikováno v:
Proceedings for Annual Meeting of The Japanese Pharmacological Society. 96:1-B
Publikováno v:
Journal of Pharmacological Sciences, Vol 136, Iss 1, Pp 42-45 (2018)
To explore memory enhancing effect of the flavonoid fisetin, we investigated the effect of oral administration of flavonoids on the induction of long-term potentiation (LTP) at hippocampal CA1 synapses of anesthetized rats. Among four flavonoids (fis
Publikováno v:
Proceedings for Annual Meeting of The Japanese Pharmacological Society. 93:3
Autor:
Kazuho Abe, Tatsuhiro Akaishi
Publikováno v:
European journal of pharmacology. 819
CNB-001, a pyrazole derivative of curcumin, has been found to exert neuroprotective and memory-enhancing effects that may be effective for the treatment of Alzheimer's disease. Since aberrant activation of microglia is involved in the pathogenesis of