Zobrazeno 1 - 10
of 103
pro vyhledávání: '"Tatsuhiko Imaoka"'
Autor:
Ryoko Semba, Takamitsu Morioka, Hiromi Yanagihara, Kenshi Suzuki, Hirotaka Tachibana, Takahiro Hamoya, Yoshiya Horimoto, Tatsuhiko Imaoka, Mitsue Saito, Shizuko Kakinuma, Masami Arai
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 165, Iss , Pp 115082- (2023)
Externí odkaz:
https://doaj.org/article/7c34a6c7af1a410bb32cb9b2a67b4670
Autor:
Ken-ichi Kudo, Naohiro Tsuyama, Kento Nagata, Tatsuhiko Imaoka, Daisuke Iizuka, Misaki Sugai-Takahashi, Moe Muramatsu, Akira Sakai
Publikováno v:
Radiation Oncology, Vol 17, Iss 1, Pp 1-15 (2022)
Abstract Background The DNA damage response (DDR) is a mechanism that protects cells against radiation-induced oxidative DNA damage by causing cell cycle arrest and apoptosis. TP63 is a member of the tumour suppressor TP53 gene family, and ΔNp63α,
Externí odkaz:
https://doaj.org/article/9aa9bd7fe56b4073953ba20e26d25001
Autor:
Ryoko Semba, Takamitsu Morioka, Hiromi Yanagihara, Kenshi Suzuki, Hirotaka Tachibana, Takahiro Hamoya, Yoshiya Horimoto, Tatsuhiko Imaoka, Mitsue Saito, Shizuko Kakinuma, Masami Arai
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 164, Iss , Pp 114968- (2023)
Therapeutic strategies that promote read-through of a mutant gene have proved effective for certain non-neoplastic diseases. However, the efficacy of this approach is unproven regarding neoplastic diseases with germline nonsense mutations, including
Externí odkaz:
https://doaj.org/article/abe3d924125341d0b3dba68bbea70347
Autor:
Yingyi Kong, Shinya Akatsuka, Yashiro Motooka, Hao Zheng, Zhen Cheng, Yukihiro Shiraki, Tomoji Mashimo, Tatsuhiko Imaoka, Shinya Toyokuni
Publikováno v:
Redox Biology, Vol 54, Iss , Pp 102356- (2022)
Germline-mutation in BRCA1 tumor suppressor gene is an established risk for carcinogenesis not only in females but also in males. Deficiency in the repair of DNA double-strand breaks is hypothesized as a responsible mechanism for carcinogenesis. Howe
Externí odkaz:
https://doaj.org/article/9383519d13d540a7b0c45cb36b1fa87a
Autor:
Mayumi Nishimura, Kazuhiro Daino, Maki Fukuda, Ikuya Tanaka, Hitomi Moriyama, Kaye Showler, Yukiko Nishimura, Masaru Takabatake, Toshiaki Kokubo, Atsuko Ishikawa, Kazumasa Inoue, Masahiro Fukushi, Shizuko Kakinuma, Tatsuhiko Imaoka, Yoshiya Shimada
Publikováno v:
PLoS ONE, Vol 16, Iss 8, p e0255968 (2021)
Copenhagen rats are highly resistant to mammary carcinogenesis, even after treatment with chemical carcinogens and hormones; most studies indicate that this is a dominant genetic trait. To test whether this trait is also dominant after radiation expo
Externí odkaz:
https://doaj.org/article/f809fc58fb0444b397ec183fc7dd069b
Autor:
Masaru Takabatake, Benjamin J Blyth, Kazuhiro Daino, Tatsuhiko Imaoka, Mayumi Nishimura, Masahiro Fukushi, Yoshiya Shimada
Publikováno v:
PLoS ONE, Vol 11, Iss 10, p e0164194 (2016)
Several lines of evidence indicate one's age at exposure to radiation strongly modifies the risk of radiation-induced breast cancer. We previously reported that rat mammary carcinomas induced by pre- and post-pubertal irradiation have distinct gene e
Externí odkaz:
https://doaj.org/article/e16ff4143a364e40b9e5fdeb7b040cab
Autor:
Kazuhiro Daino, Tatsuhiko Imaoka, Takamitsu Morioka, Shusuke Tani, Daisuke Iizuka, Mayumi Nishimura, Yoshiya Shimada
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e74013 (2013)
BRIP1 is a DNA helicase that directly interacts with the C-terminal BRCT repeat of the breast cancer susceptibility protein BRCA1 and plays an important role in BRCA1-dependent DNA repair and DNA damage-induced checkpoint control. Recent studies impl
Externí odkaz:
https://doaj.org/article/19b645967b984f8d880a28b2ab0adad7
Publikováno v:
Anticancer Research. 43:2551-2559
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::37dbb575f4c334535ee5b3ea1a1f58da
https://doi.org/10.21873/anticanres.16422
https://doi.org/10.21873/anticanres.16422
Autor:
Hiromi Yanagihara, Takamitsu Morioka, Shunsuke Yamazaki, Yutaka Yamada, Hirotaka Tachibana, Kazuhiro Daino, Chizuru Tsuruoka, Yoshiko Amasaki, Mutsumi Kaminishi, Tatsuhiko Imaoka, Shizuko Kakinuma
Publikováno v:
Journal of Radiation Research. 64:622-631
Recent studies have identified interstitial deletions in the cancer genome as a radiation-related mutational signature, although most of them do not fall on cancer driver genes. Pioneering studies in the field have indicated the presence of loss of h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::81c6ebceeb9d202dfee6de85bd3d84a3
https://doi.org/10.1093/jrr/rrad021
https://doi.org/10.1093/jrr/rrad021
Autor:
Keiji Suzuki, Tatsuhiko Imaoka, Masanori Tomita, Megumi Sasatani, Kazutaka Doi, Satoshi Tanaka, Michiaki Kai, Yutaka Yamada, Shizuko Kakinuma
Publikováno v:
Journal of Radiation Research. 64(2):228-249
While epidemiological data have greatly contributed to the estimation of the dose and dose-rate effectiveness factor (DDREF) for human populations, studies using animal models have made significant contributions to provide quantitative data with mech
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51d26a3ce84a6ba8bbbe42329b0757f6
https://nagasaki-u.repo.nii.ac.jp/records/28075
https://nagasaki-u.repo.nii.ac.jp/records/28075