Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Tatsuhiko Fujimoto"'
Autor:
Tatsuhiko Fujimoto, Kentaro Rikimaru, Koichiro Fukuda, Hiromichi Sugimoto, Kei Masuda, Norio Ohyabu, Yoshihiro Banno, Norihito Tokunaga, Tetsuji Kawamoto, Yoshihide Tomata, Yasumi Kumagai, Motoo Iida, Yoichi Nagano, Mariko Yoneyama-Hirozane, Yuji Shimizu, Katsunori Sasa, Takashi Ishikawa, Hiroshi Yukitake, Mitsuhiro Ito, Kazunobu Aoyama, Takahiro Matsumoto
Publikováno v:
ACS Medicinal Chemistry Letters. 13:457-462
TAK-925, a potent, selective, and brain-penetrant orexin 2 receptor (OX2R) agonist, [methyl (2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c87b9a348e001ee09f5f334fe8ecffc
https://doi.org/10.1021/acsmedchemlett.1c00626
https://doi.org/10.1021/acsmedchemlett.1c00626
Autor:
Motohisa Suzuki, Atsushi Suzuki, Hiroshi Yukitake, Haruhide Kimura, Mitsuhiro Ito, Tatsuhiko Fujimoto, Yuji Shimizu, Kentaro Rikimaru, T Ishikawa
Publikováno v:
Pharmacology Biochemistry and Behavior. 187:172794
Orexin-producing neurons in the lateral hypothalamus are a critical regulator of sleep/wake states, and their loss is associated with narcolepsy type 1 (NT1). Orexin peptides act on two G protein-coupled receptors: orexin 1 receptor (OX1R) and orexin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ebf31a389339bfd82316c78b043688b
https://doi.org/10.1016/j.pbb.2019.172794
https://doi.org/10.1016/j.pbb.2019.172794
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:6409-6413
To generate novel human Orexin-2 Receptor (OX2R) antagonists, a spiropiperidine based scaffold was designed and a SAR study was carried out. Compound 4f possessed the highest OX2R antagonistic activity with an IC(50) value of 3nM with 450-fold select
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15888cd18d06049c027d291b9ffbd7f5
https://doi.org/10.1016/j.bmcl.2011.08.094
https://doi.org/10.1016/j.bmcl.2011.08.094
Autor:
Yoshihide Tomata, Mariko Hirozane, Jun Kunitomo, Shin-ichi Yoshikubo, Tatsuhiko Fujimoto, Keisuke Hirai, Keiji Nishiyama, Masato Nakashima, Shogo Marui
Publikováno v:
Bioorganicmedicinal chemistry letters. 21(21)
During our efforts to identify a series of potent, selective, orally active human Orexin-2 Receptor (OX2R) antagonists, we elucidated structure-activity relationship (SAR) on the 7-position of a benzoxazepine scaffold by utilizing Hammett σp and Han
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a524aafca299ff378c32ce7689d73389
https://pubmed.ncbi.nlm.nih.gov/21917455
https://pubmed.ncbi.nlm.nih.gov/21917455
Autor:
Yusuke Moritoh, Jason Yano, Shigetoshi Tsubotani, Takuo Kosaka, Yoshihiro Banno, Michiko Amano, Osamu Kataoka, Yasufumi Miyamoto, Koji Takeuchi, Masako Sasaki, Satoru Oi, Tomoko Asakawa, Nobuhiro Suzuki, Akiyoshi Tani, Hiroaki Yashiro, Yoshio Yamamoto, Hironobu Maezaki, Koji Ikedo, Miyuki Funami, Kathleen Aertgeerts, Tohru Yamashita, Tatsuhiko Fujimoto
Publikováno v:
Journal of medicinal chemistry. 54(3)
Inhibition of dipeptidyl peptidase IV (DPP-4) is an exciting new approach for the treatment of diabetes. To date there has been no DPP-4 chemotype possessing a carboxy group that has progressed into clinical trials. Originating from the discovery of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aeae4babf3e7e59050f5860dd928f31e
https://pubmed.ncbi.nlm.nih.gov/21218817
https://pubmed.ncbi.nlm.nih.gov/21218817
Publikováno v:
Tetrahedron Letters. 42:7987-7989
For achieving the on–off operation of the superstructure formation of hermaphrodite cyclodextrin derivatives, we synthesized azobenzene-modified permethylated α-cyclodextrins, 1 and 2. These compounds formed Janus [2]pseudorotaxanes in CD3OD–D2O
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::139813d9a4dc49ad1d912e3c984a6e38
https://doi.org/10.1016/s0040-4039(01)01563-5
https://doi.org/10.1016/s0040-4039(01)01563-5
Autor:
Nobuhiro Suzuki, Osamu Kataoka, Tatsuhiko Fujimoto, Hironobu Maezaki, Shigetoshi Tsubotani, Koji Takeuchi, Akiyoshi Tani, Yasufumi Miyamoto, Yoshio Yamamoto, Takuo Kosaka, Michiko Amano, Kathleen Aertgeerts, Yusuke Moritoh, Yoshihiro Banno, Satoru Oi, Jason Yano, Tomoko Asakawa, Koji Ikedo, Miyuki Funami, Tohru Yamashita
Publikováno v:
Bioorganicmedicinal chemistry. 19(1)
We have previously discovered nicotinic acid derivative 1 as a structurally novel dipeptidyl peptidase IV (DPP-4) inhibitor. In this study, we obtained the X-ray co-crystal structure between nicotinic acid derivative 1 and DPP-4. From these X-ray co-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b49d316e011ec909e3607b364e47733
https://pubmed.ncbi.nlm.nih.gov/21163664
https://pubmed.ncbi.nlm.nih.gov/21163664
Publikováno v:
ChemInform. 33
The first [5]supercyclodextrin 1s whose nano-sized cyclopentameric array is held only by a mechanical bond was synthesized by the pentakis-azo coupling of a new hermaphrodite monomer 2 with 2-naphthol as a stopper, isolated by chromatography, and cha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ce84a059a682e2fa759e99d6559144fb
https://doi.org/10.1002/chin.200218191
https://doi.org/10.1002/chin.200218191
Autor:
Hitoshi Miyasaka, Ken-ichi Sugiura, Kazuki Nakamura, Osamu Yamane, Takahiro Kaneda, Yoshiteru Sakata, Kazuya Nakamura, Masahiro Yamashita, Tatsuhiko Fujimoto
Publikováno v:
ChemInform. 35
We prepared novel pyrene-fused porphyrins via the oxidative intramolecular ring closure reactions of meso-pyrenylporphyrin. The excitation energies and the oxidation potentials of the isolated dark...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f74e1e9a4798b3e5a7e800a4de1ddfe0
https://doi.org/10.1002/chin.200419106
https://doi.org/10.1002/chin.200419106
Publikováno v:
Journal of the American Society for Mass Spectrometry. 14(10)
The solution-based self-assembly of native and permethylated cyclodextrins (CD) bearing an azobenzene substituent has been studied by electrospray ionization mass spectrometry (ESI-MS). The results revealed that the CD molecules form either a contact
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::190b7fda3d46b8d5c62b160f2a757b76
https://pubmed.ncbi.nlm.nih.gov/14530092
https://pubmed.ncbi.nlm.nih.gov/14530092