Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Tatosian, DA"'
Autor:
Krug, AW, Vaddady, P, Railkar, RA, Musser, BJ, Cote, J, Ederveen, AGH, Krefetz, DG, DeNoia, E, Free, AL, Morrow, L, Chakravarthy, MV, Kauh, E, Tatosian, DA, Kothare, PA
Publikováno v:
Clinical and Translational Science
GPR40 mediates free fatty acid–induced insulin secretion in beta cells. We investigated the safety, pharmacokinetics, and glucose response of MK‐8666, a partial GPR40 agonist, after once‐daily multiple dosing in type 2 diabetes patients. This d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::db8794db28437615e24de0ecb7d9b4b9
http://europepmc.org/articles/PMC5593169
http://europepmc.org/articles/PMC5593169
Autor:
Prueksaritanont, T, Tatosian, DA, Chu, X, Railkar, R, Evers, R, Chavez‐Eng, C, Lutz, R, Zeng, W, Yabut, J, Chan, GH, Cai, X, Latham, AH, Hehman, J, Stypinski, D, Brejda, J, Zhou, C, Thornton, B, Bateman, KP, Fraser, I, Stoch, SA
Publikováno v:
Clinical Pharmacology & Therapeutics; Apr2017, Vol. 101 Issue 4, p519-530, 12p
Akademický článek
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Autor:
Ye Y; Bristol Myers Squibb, Princeton, New Jersey, USA., Gaudy A; Bristol Myers Squibb, Princeton, New Jersey, USA., Thomas M; Bristol Myers Squibb, Princeton, New Jersey, USA., Reyes J; Bristol Myers Squibb, Princeton, New Jersey, USA., Burkhardt B; Bristol Myers Squibb, Princeton, New Jersey, USA., Horan G; Bristol Myers Squibb, Princeton, New Jersey, USA., Liu L; Bristol Myers Squibb, Princeton, New Jersey, USA., Chen J; Bristol Myers Squibb, Princeton, New Jersey, USA., Ghosh A; Bristol Myers Squibb, Princeton, New Jersey, USA., Carayannopoulos LN; Bristol Myers Squibb, Princeton, New Jersey, USA., Tatosian DA; Bristol Myers Squibb, Princeton, New Jersey, USA., Palmisano M; Bristol Myers Squibb, Princeton, New Jersey, USA.
Publikováno v:
Clinical pharmacology in drug development [Clin Pharmacol Drug Dev] 2022 Dec; Vol. 11 (12), pp. 1394-1404. Date of Electronic Publication: 2022 Oct 18.
Autor:
Tatosian DA; Merck & Co., Inc., Kenilworth, New Jersey, USA., Yee KL; Merck & Co., Inc., Kenilworth, New Jersey, USA., Zhang Z; Merck & Co., Inc., Kenilworth, New Jersey, USA., Mostoller K; Merck & Co., Inc., Kenilworth, New Jersey, USA., Paul E; Merck & Co., Inc., Kenilworth, New Jersey, USA., Sutradhar S; Merck & Co., Inc., Kenilworth, New Jersey, USA., Larson P; Merck & Co., Inc., Kenilworth, New Jersey, USA., Chhibber A; Merck & Co., Inc., Kenilworth, New Jersey, USA., Wen J; Merck & Co., Inc., Kenilworth, New Jersey, USA., Wang YJ; Merck & Co., Inc., Kenilworth, New Jersey, USA., Lassman M; Merck & Co., Inc., Kenilworth, New Jersey, USA., Latham AH; Merck & Co., Inc., Kenilworth, New Jersey, USA., Pang J; Merck & Co., Inc., Kenilworth, New Jersey, USA., Crumley T; Merck & Co., Inc., Kenilworth, New Jersey, USA., Gillespie A; Data Management and Biometrics, Celerion, Lincoln, Nebraska, USA., Marricco NC; Data Management and Biometrics, Celerion, Lincoln, Nebraska, USA., Marenco T; Data Management and Biometrics, Celerion, Lincoln, Nebraska, USA., Murphy M; Data Management and Biometrics, Celerion, Lincoln, Nebraska, USA., Lasseter KC; Clinical Pharmacology of Miami, Inc, Miami, Florida, USA., Marbury TC; Orlando Clinical Research Center, Orlando, Florida, USA., Tweedie D; Merck & Co., Inc., Kenilworth, New Jersey, USA.; Currently Independent Consultant, Harleysville, Pennsylvania, USA., Chu X; Merck & Co., Inc., Kenilworth, New Jersey, USA., Evers R; Merck & Co., Inc., Kenilworth, New Jersey, USA., Stoch SA; Merck & Co., Inc., Kenilworth, New Jersey, USA.
Publikováno v:
Clinical pharmacology and therapeutics [Clin Pharmacol Ther] 2021 Feb; Vol. 109 (2), pp. 403-415. Date of Electronic Publication: 2020 Oct 26.
Autor:
Jain L; Merck & Co., Inc., Kenilworth, NJ, USA., Chain ASY; Merck & Co., Inc., Kenilworth, NJ, USA., Tatosian DA; Merck & Co., Inc., Kenilworth, NJ, USA., Hing J; Cognigen Corporation, a Simulations Plus Company, Buffalo, NY, USA., Passarell JA; Cognigen Corporation, a Simulations Plus Company, Buffalo, NY, USA., Kauh EA; Merck & Co., Inc., Kenilworth, NJ, USA., Lai E; Merck & Co., Inc., Kenilworth, NJ, USA.
Publikováno v:
British journal of clinical pharmacology [Br J Clin Pharmacol] 2019 Dec; Vol. 85 (12), pp. 2759-2771. Date of Electronic Publication: 2019 Dec 09.
Autor:
Fraser IP; Departments of Clinical Research, Pharmacokinetics and Biostatistics, Merck & Co., Inc., Kenilworth, New Jersey., Neufeld ND; Neufeld Medical Group, West Hollywood, California., Fox LA; Department of Endocrinology and Diabetes, Nemours Children's Health System, Jacksonville, Florida., Kipnes MS; Diabetes and Glandular Disease Clinic, San Antonio, Texas., Miller TL; Department of Pediatrics, Miller School of Medicine, University of Miami, Miami, Florida., Zeitler PS; Pediatric Endocrinology, University of Colorado School of Medicine, Children's Hospital Colorado, Aurora, Colorado., Rodriguez H; Pediatric Diabetes Clinical Program, James Whitcomb Riley Hospital for Children, Indianapolis, Indiana., Gilmartin JH; Departments of Clinical Research, Pharmacokinetics and Biostatistics, Merck & Co., Inc., Kenilworth, New Jersey., Lee SJ; Departments of Clinical Research, Pharmacokinetics and Biostatistics, Merck & Co., Inc., Kenilworth, New Jersey., Patterson JK; Departments of Clinical Research, Pharmacokinetics and Biostatistics, Merck & Co., Inc., Kenilworth, New Jersey., Li XS; Departments of Clinical Research, Pharmacokinetics and Biostatistics, Merck & Co., Inc., Kenilworth, New Jersey., Maganti L; Departments of Clinical Research, Pharmacokinetics and Biostatistics, Merck & Co., Inc., Kenilworth, New Jersey., Luo WL; Departments of Clinical Research, Pharmacokinetics and Biostatistics, Merck & Co., Inc., Kenilworth, New Jersey., Tatosian DA; Departments of Clinical Research, Pharmacokinetics and Biostatistics, Merck & Co., Inc., Kenilworth, New Jersey., Stoch SA; Departments of Clinical Research, Pharmacokinetics and Biostatistics, Merck & Co., Inc., Kenilworth, New Jersey.
Publikováno v:
Pediatric diabetes [Pediatr Diabetes] 2019 Feb; Vol. 20 (1), pp. 48-56. Date of Electronic Publication: 2018 Nov 13.
Autor:
Chen HY; Departments of Discovery Chemistry, Process Chemistry, Pharmacokinetics, Pharmacodynamics and Drug Metabolism, In Vivo Pharmacology, and In Vitro Pharmacology, Merck & Co., Inc., Kenilworth, New Jersey 07033, United States., Plummer CW; Departments of Discovery Chemistry, Process Chemistry, Pharmacokinetics, Pharmacodynamics and Drug Metabolism, In Vivo Pharmacology, and In Vitro Pharmacology, Merck & Co., Inc., Kenilworth, New Jersey 07033, United States., Xiao D; Departments of Discovery Chemistry, Process Chemistry, Pharmacokinetics, Pharmacodynamics and Drug Metabolism, In Vivo Pharmacology, and In Vitro Pharmacology, Merck & Co., Inc., Kenilworth, New Jersey 07033, United States., Chobanian HR; Departments of Discovery Chemistry, Process Chemistry, Pharmacokinetics, Pharmacodynamics and Drug Metabolism, In Vivo Pharmacology, and In Vitro Pharmacology, Merck & Co., Inc., Kenilworth, New Jersey 07033, United States., DeMong D; Departments of Discovery Chemistry, Process Chemistry, Pharmacokinetics, Pharmacodynamics and Drug Metabolism, In Vivo Pharmacology, and In Vitro Pharmacology, Merck & Co., Inc., Kenilworth, New Jersey 07033, United States., Miller M; Departments of Discovery Chemistry, Process Chemistry, Pharmacokinetics, Pharmacodynamics and Drug Metabolism, In Vivo Pharmacology, and In Vitro Pharmacology, Merck & Co., Inc., Kenilworth, New Jersey 07033, United States., Trujillo ME; Departments of Discovery Chemistry, Process Chemistry, Pharmacokinetics, Pharmacodynamics and Drug Metabolism, In Vivo Pharmacology, and In Vitro Pharmacology, Merck & Co., Inc., Kenilworth, New Jersey 07033, United States., Kirkland M; Departments of Discovery Chemistry, Process Chemistry, Pharmacokinetics, Pharmacodynamics and Drug Metabolism, In Vivo Pharmacology, and In Vitro Pharmacology, Merck & Co., Inc., Kenilworth, New Jersey 07033, United States., Kosinski D; Departments of Discovery Chemistry, Process Chemistry, Pharmacokinetics, Pharmacodynamics and Drug Metabolism, In Vivo Pharmacology, and In Vitro Pharmacology, Merck & Co., Inc., Kenilworth, New Jersey 07033, United States., Mane J; Departments of Discovery Chemistry, Process Chemistry, Pharmacokinetics, Pharmacodynamics and Drug Metabolism, In Vivo Pharmacology, and In Vitro Pharmacology, Merck & Co., Inc., Kenilworth, New Jersey 07033, United States., Pachanski M; Departments of Discovery Chemistry, Process Chemistry, Pharmacokinetics, Pharmacodynamics and Drug Metabolism, In Vivo Pharmacology, and In Vitro Pharmacology, Merck & Co., Inc., Kenilworth, New Jersey 07033, United States., Cheewatrakoolpong B; Departments of Discovery Chemistry, Process Chemistry, Pharmacokinetics, Pharmacodynamics and Drug Metabolism, In Vivo Pharmacology, and In Vitro Pharmacology, Merck & Co., Inc., Kenilworth, New Jersey 07033, United States., Di Salvo J; Departments of Discovery Chemistry, Process Chemistry, Pharmacokinetics, Pharmacodynamics and Drug Metabolism, In Vivo Pharmacology, and In Vitro Pharmacology, Merck & Co., Inc., Kenilworth, New Jersey 07033, United States., Thomas-Fowlkes B; Departments of Discovery Chemistry, Process Chemistry, Pharmacokinetics, Pharmacodynamics and Drug Metabolism, In Vivo Pharmacology, and In Vitro Pharmacology, Merck & Co., Inc., Kenilworth, New Jersey 07033, United States., Souza S; Departments of Discovery Chemistry, Process Chemistry, Pharmacokinetics, Pharmacodynamics and Drug Metabolism, In Vivo Pharmacology, and In Vitro Pharmacology, Merck & Co., Inc., Kenilworth, New Jersey 07033, United States., Tatosian DA; Departments of Discovery Chemistry, Process Chemistry, Pharmacokinetics, Pharmacodynamics and Drug Metabolism, In Vivo Pharmacology, and In Vitro Pharmacology, Merck & Co., Inc., Kenilworth, New Jersey 07033, United States., Chen Q; Departments of Discovery Chemistry, Process Chemistry, Pharmacokinetics, Pharmacodynamics and Drug Metabolism, In Vivo Pharmacology, and In Vitro Pharmacology, Merck & Co., Inc., Kenilworth, New Jersey 07033, United States., Hafey MJ; Departments of Discovery Chemistry, Process Chemistry, Pharmacokinetics, Pharmacodynamics and Drug Metabolism, In Vivo Pharmacology, and In Vitro Pharmacology, Merck & Co., Inc., Kenilworth, New Jersey 07033, United States., Houle R; Departments of Discovery Chemistry, Process Chemistry, Pharmacokinetics, Pharmacodynamics and Drug Metabolism, In Vivo Pharmacology, and In Vitro Pharmacology, Merck & Co., Inc., Kenilworth, New Jersey 07033, United States., Nolting AF; Departments of Discovery Chemistry, Process Chemistry, Pharmacokinetics, Pharmacodynamics and Drug Metabolism, In Vivo Pharmacology, and In Vitro Pharmacology, Merck & Co., Inc., Kenilworth, New Jersey 07033, United States., Orr R; Departments of Discovery Chemistry, Process Chemistry, Pharmacokinetics, Pharmacodynamics and Drug Metabolism, In Vivo Pharmacology, and In Vitro Pharmacology, Merck & Co., Inc., Kenilworth, New Jersey 07033, United States., Ehrhart J; Departments of Discovery Chemistry, Process Chemistry, Pharmacokinetics, Pharmacodynamics and Drug Metabolism, In Vivo Pharmacology, and In Vitro Pharmacology, Merck & Co., Inc., Kenilworth, New Jersey 07033, United States., Weinglass AB; Departments of Discovery Chemistry, Process Chemistry, Pharmacokinetics, Pharmacodynamics and Drug Metabolism, In Vivo Pharmacology, and In Vitro Pharmacology, Merck & Co., Inc., Kenilworth, New Jersey 07033, United States., Tschirret-Guth R; Departments of Discovery Chemistry, Process Chemistry, Pharmacokinetics, Pharmacodynamics and Drug Metabolism, In Vivo Pharmacology, and In Vitro Pharmacology, Merck & Co., Inc., Kenilworth, New Jersey 07033, United States., Howard AD; Departments of Discovery Chemistry, Process Chemistry, Pharmacokinetics, Pharmacodynamics and Drug Metabolism, In Vivo Pharmacology, and In Vitro Pharmacology, Merck & Co., Inc., Kenilworth, New Jersey 07033, United States., Colletti SL; Departments of Discovery Chemistry, Process Chemistry, Pharmacokinetics, Pharmacodynamics and Drug Metabolism, In Vivo Pharmacology, and In Vitro Pharmacology, Merck & Co., Inc., Kenilworth, New Jersey 07033, United States.
Publikováno v:
ACS medicinal chemistry letters [ACS Med Chem Lett] 2018 Jun 14; Vol. 9 (7), pp. 685-690. Date of Electronic Publication: 2018 Jun 14 (Print Publication: 2018).
Autor:
Berger JP; Merck& Co., Inc. Kenilworth NJ USA.; Present address: Takeda Pharmaceuticals International, Inc. Cambridge MA USA., SinhaRoy R; Merck& Co., Inc. Kenilworth NJ USA.; Present address: Janssen Pharmaceuticals, Inc. Titusville NJ USA., Pocai A; Merck& Co., Inc. Kenilworth NJ USA.; Present address: Janssen Pharmaceuticals, Inc. Titusville NJ USA., Kelly TM; Merck& Co., Inc. Kenilworth NJ USA., Scapin G; Merck& Co., Inc. Kenilworth NJ USA., Gao YD; Merck& Co., Inc. Kenilworth NJ USA., Pryor KAD; Merck& Co., Inc. Kenilworth NJ USA., Wu JK; Merck& Co., Inc. Kenilworth NJ USA., Eiermann GJ; Merck& Co., Inc. Kenilworth NJ USA., Xu SS; Merck& Co., Inc. Kenilworth NJ USA., Zhang X; Merck& Co., Inc. Kenilworth NJ USA., Tatosian DA; Merck& Co., Inc. Kenilworth NJ USA., Weber AE; Merck& Co., Inc. Kenilworth NJ USA.; Present address: Kallyope Inc. New York NY USA., Thornberry NA; Merck& Co., Inc. Kenilworth NJ USA.; Present address: Kallyope Inc. New York NY USA., Carr RD; MSD A/S Copenhagen Denmark.; University College London UK.
Publikováno v:
Endocrinology, diabetes & metabolism [Endocrinol Diabetes Metab] 2017 Nov 24; Vol. 1 (1), pp. e00002. Date of Electronic Publication: 2017 Nov 24 (Print Publication: 2018).
Autor:
Pachanski MJ; In Vivo Pharmacology, Merck & Co., Inc., Kenilworth, New Jersey, United States of America., Kirkland ME; In Vivo Pharmacology, Merck & Co., Inc., Kenilworth, New Jersey, United States of America., Kosinski DT; In Vivo Pharmacology, Merck & Co., Inc., Kenilworth, New Jersey, United States of America., Mane J; In Vivo Pharmacology, Merck & Co., Inc., Kenilworth, New Jersey, United States of America., Cheewatrakoolpong B; In Vivo Pharmacology, Merck & Co., Inc., Kenilworth, New Jersey, United States of America., Xue J; In Vivo Pharmacology, Merck & Co., Inc., Kenilworth, New Jersey, United States of America., Szeto D; In Vivo Pharmacology, Merck & Co., Inc., Kenilworth, New Jersey, United States of America., Forrest G; In Vivo Pharmacology, Merck & Co., Inc., Kenilworth, New Jersey, United States of America., Miller C; Translational Imaging Biomarkers, Merck & Co., Inc., Kenilworth, New Jersey, United States of America., Bunzel M; Translational Imaging Biomarkers, Merck & Co., Inc., Kenilworth, New Jersey, United States of America., Plummer CW; Department of Medicinal Chemistry, Merck & Co., Inc., Kenilworth, New Jersey, United States of America., Chobanian HR; Department of Medicinal Chemistry, Merck & Co., Inc., Kenilworth, New Jersey, United States of America., Miller MW; Department of Medicinal Chemistry, Merck & Co., Inc., Kenilworth, New Jersey, United States of America., Souza S; In Vivo Pharmacology, Merck & Co., Inc., Kenilworth, New Jersey, United States of America., Thomas-Fowlkes BS; In Vivo Pharmacology, Merck & Co., Inc., Kenilworth, New Jersey, United States of America., Ogawa AM; In Vivo Pharmacology, Merck & Co., Inc., Kenilworth, New Jersey, United States of America., Weinglass AB; In Vivo Pharmacology, Merck & Co., Inc., Kenilworth, New Jersey, United States of America., Di Salvo J; In Vivo Pharmacology, Merck & Co., Inc., Kenilworth, New Jersey, United States of America., Li X; Department of Cardio Metabolic Diseases, Merck & Co., Inc., Kenilworth, New Jersey, United States of America., Feng Y; Department of Cardio Metabolic Diseases, Merck & Co., Inc., Kenilworth, New Jersey, United States of America., Tatosian DA; Pharmacokinetics, Pharmacodynamics and Drug Metabolism, Merck & Co., Inc., Kenilworth, New Jersey, United States of America., Howard AD; Department of Cardio Metabolic Diseases, Merck & Co., Inc., Kenilworth, New Jersey, United States of America., Colletti SL; Department of Medicinal Chemistry, Merck & Co., Inc., Kenilworth, New Jersey, United States of America., Trujillo ME; In Vivo Pharmacology, Merck & Co., Inc., Kenilworth, New Jersey, United States of America.
Publikováno v:
PloS one [PLoS One] 2017 Oct 20; Vol. 12 (10), pp. e0186033. Date of Electronic Publication: 2017 Oct 20 (Print Publication: 2017).