Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Tatos N. Akopian"'
Autor:
Ravikiran M Raju, Meera Unnikrishnan, Daniel H F Rubin, Vidhya Krishnamoorthy, Olga Kandror, Tatos N Akopian, Alfred L Goldberg, Eric J Rubin
Publikováno v:
PLoS Pathogens, Vol 8, Iss 2, p e1002511 (2012)
In most bacteria, Clp protease is a conserved, non-essential serine protease that regulates the response to various stresses. Mycobacteria, including Mycobacterium tuberculosis (Mtb) and Mycobacterium smegmatis, unlike most well studied prokaryotes,
Externí odkaz:
https://doaj.org/article/f65d28a004664db1bb31331803333570
Autor:
Chu-Lai Hsiao, Ramesh A. Bhat, Rayomand J Unwalla, Zhang B. Xu, Karl Malakian, William S. Somers, Tatos N. Akopian, Wah-Tung Hum, Heather A. Harris, Eric S. Manas, Michael S. Malamas, Juan C. Alvarez, Ashok R. Bapat, Scott Wolfrom, Chris P. Miller, Mark Stahl
Publikováno v:
Journal of the American Chemical Society. 126:15106-15119
We present the structure-based optimization of a series of estrogen receptor-beta (ERbeta) selective ligands. X-ray cocrystal structures of these ligands complexed to both ERalpha and ERbeta are described. We also discuss how molecular modeling was u
Autor:
Jonathan A. Bard, Kristie Grove Bridges, Bethany Annis-Freeman, Rajiv Chopra, Richard Zollner, Kristine Svenson, Edward R. Lavallie, Tod H. Marvell, Amy Tam, Rebecca Cowling, Laura Lin, Elizabeth DiBlasio-Smith, William S. Somers, Guixian Jin, Ronald W. Kriz, Tatos N. Akopian, Mark Stahl, Frank Lovering
Publikováno v:
Peptides. 27(7)
β-Secretase 1 (BACE1) is an aspartic protease believed to play a critical role in Alzheimer's disease. Inhibitors of this enzyme have been designed by incorporating the non-cleavable hydroxyethylene and statine isosteres into peptides corresponding