Amplification of TGF beta Induced ITGB6 Gene Transcription May Promote Pulmonary Fibrosis

Autor: Wolters, Paul, Tatler, AL, Goodwin, AT, Gbolahan, O, Saini, G, Porte, J, John, AE, Clifford, RL, Violette, SM, Weinreb, PH, Parfrey, H

Publikováno v: Wolters, Paul; Tatler, AL; Goodwin, AT; Gbolahan, O; Saini, G; Porte, J; et al.(2016). Amplification of TGF beta Induced ITGB6 Gene Transcription May Promote Pulmonary Fibrosis. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/16s077nx

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::466ad8e6600088671c782f5c037823f7
http://www.escholarship.org/uc/item/16s077nx

Reduced ets domain-containing protein Elk1 promotes pulmonary fibrosis via increased integrin alpha v beta 6 expression

Autor: Tatler, AL, Habgood, A, Porte, J, John, AE, Stavrou, A, Hodge, E, Kerama-Likoko, C, Violette, SM, Weinreb, PH, Knox, AJ, Laurent, G, Parfrey, H, Wolters, PJ, Wallace, W, Alberti, S, Nordheim, A, Jenkins, G

Idiopathic pulmonary fibrosis (IPF) is a progressive fibrotic lung disease with high mortality. Active TGFβ1 is considered central to the pathogenesis of IPF. A major mechanism of TGFβ1 activation in the lung involves the epithelially restricted α

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______1032::abb8a0d8003cc928ba36e324fd96b18c
http://hdl.handle.net/10044/1/97008

S86 Extracellular matrix deposited by asthmatic human airway smooth muscle cells enhances basal activation of tgfβ

Autor: Cairns, JT, Krishnan, R, John, AE, Brightling, CE, Shaw, DE, Jenkins, G, Tatler, AL

Publikováno v: Thorax; 2017, Vol. 72 Issue: Supplement 3 pA53-A54, 2p

S75 Cyclical stretch induces gαq/11 mediated tgfβ activation in lung fibroblasts

Autor: Goodwin, AT, Tatler, AL, Offermanns, S, Jenkins, G

Publikováno v: Thorax; 2017, Vol. 72 Issue: Supplement 3 pA47-A47, 1p

Stretch regulates alveologenesis and homeostasis via mesenchymal Gαq/11-mediated TGFβ2 activation.

Autor: Goodwin AT; Centre for Respiratory Research, Translational Medical Sciences, School of Medicine, University of Nottingham, Nottingham, NG7 2RD, UK.; Respiratory Medicine, Nottingham NIHR Biomedical Research Centre, Nottingham, NG7 2RD, UK.; Respiratory Medicine, Biodiscovery Institute, University Park, University of Nottingham, Nottingham, NG7 2RD, UK., John AE; Margaret Turner Warwick Centre for Fibrosing Lung Disease, National Heart and Lung Institute, Imperial College London, London, SW3 6LY, UK., Joseph C; Centre for Respiratory Research, Translational Medical Sciences, School of Medicine, University of Nottingham, Nottingham, NG7 2RD, UK.; Respiratory Medicine, Nottingham NIHR Biomedical Research Centre, Nottingham, NG7 2RD, UK.; Respiratory Medicine, Biodiscovery Institute, University Park, University of Nottingham, Nottingham, NG7 2RD, UK., Habgood A; Centre for Respiratory Research, Translational Medical Sciences, School of Medicine, University of Nottingham, Nottingham, NG7 2RD, UK.; Respiratory Medicine, Nottingham NIHR Biomedical Research Centre, Nottingham, NG7 2RD, UK.; Respiratory Medicine, Biodiscovery Institute, University Park, University of Nottingham, Nottingham, NG7 2RD, UK., Tatler AL; Centre for Respiratory Research, Translational Medical Sciences, School of Medicine, University of Nottingham, Nottingham, NG7 2RD, UK.; Respiratory Medicine, Nottingham NIHR Biomedical Research Centre, Nottingham, NG7 2RD, UK.; Respiratory Medicine, Biodiscovery Institute, University Park, University of Nottingham, Nottingham, NG7 2RD, UK., Susztak K; Department of Medicine, Division of Nephrology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA., Palmer M; Department of Pathology, Division of Nephrology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104-4238, USA., Offermanns S; Department of Pharmacology, Max Planck Institute for Heart and Lung Research, 61231 Bad Nauheim, Germany., Henderson NC; Centre for Inflammation Research, University of Edinburgh, EH16 4TJ, UK.; MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, EH4 2XU, UK., Jenkins RG; Margaret Turner Warwick Centre for Fibrosing Lung Disease, National Heart and Lung Institute, Imperial College London, London, SW3 6LY, UK.

Publikováno v: Development (Cambridge, England) [Development] 2023 May 01; Vol. 150 (9). Date of Electronic Publication: 2023 May 12.