Pathobiology of Airway Remodeling in Asthma: The Emerging Role of Integrins

Autor: Joseph C, Tatler AL

Publikováno v: Journal of Asthma and Allergy, Vol Volume 15, Pp 595-610 (2022)

Chitra Joseph, Amanda L Tatler Centre for Respiratory Research, National Institute for Health Research Biomedical Research Centre, School of Medicine, University of Nottingham, Nottingham, UKCorrespondence: Amanda L Tatler, Centre for Respiratory Res

Externí odkaz: https://doaj.org/article/9e99e502892942cfaa5018a95534d8da

Stretch regulates alveologenesis and homeostasis via mesenchymal Gαq/11-mediated TGFβ2 activation.

Autor: Goodwin AT; Centre for Respiratory Research, Translational Medical Sciences, School of Medicine, University of Nottingham, Nottingham, NG7 2RD, UK.; Respiratory Medicine, Nottingham NIHR Biomedical Research Centre, Nottingham, NG7 2RD, UK.; Respiratory Medicine, Biodiscovery Institute, University Park, University of Nottingham, Nottingham, NG7 2RD, UK., John AE; Margaret Turner Warwick Centre for Fibrosing Lung Disease, National Heart and Lung Institute, Imperial College London, London, SW3 6LY, UK., Joseph C; Centre for Respiratory Research, Translational Medical Sciences, School of Medicine, University of Nottingham, Nottingham, NG7 2RD, UK.; Respiratory Medicine, Nottingham NIHR Biomedical Research Centre, Nottingham, NG7 2RD, UK.; Respiratory Medicine, Biodiscovery Institute, University Park, University of Nottingham, Nottingham, NG7 2RD, UK., Habgood A; Centre for Respiratory Research, Translational Medical Sciences, School of Medicine, University of Nottingham, Nottingham, NG7 2RD, UK.; Respiratory Medicine, Nottingham NIHR Biomedical Research Centre, Nottingham, NG7 2RD, UK.; Respiratory Medicine, Biodiscovery Institute, University Park, University of Nottingham, Nottingham, NG7 2RD, UK., Tatler AL; Centre for Respiratory Research, Translational Medical Sciences, School of Medicine, University of Nottingham, Nottingham, NG7 2RD, UK.; Respiratory Medicine, Nottingham NIHR Biomedical Research Centre, Nottingham, NG7 2RD, UK.; Respiratory Medicine, Biodiscovery Institute, University Park, University of Nottingham, Nottingham, NG7 2RD, UK., Susztak K; Department of Medicine, Division of Nephrology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA., Palmer M; Department of Pathology, Division of Nephrology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104-4238, USA., Offermanns S; Department of Pharmacology, Max Planck Institute for Heart and Lung Research, 61231 Bad Nauheim, Germany., Henderson NC; Centre for Inflammation Research, University of Edinburgh, EH16 4TJ, UK.; MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, EH4 2XU, UK., Jenkins RG; Margaret Turner Warwick Centre for Fibrosing Lung Disease, National Heart and Lung Institute, Imperial College London, London, SW3 6LY, UK.

Publikováno v: Development (Cambridge, England) [Development] 2023 May 01; Vol. 150 (9). Date of Electronic Publication: 2023 May 12.

Complex roles of TGF-β signaling pathways in lung development and bronchopulmonary dysplasia.

Autor: Calthorpe RJ; Lifespan & Population Health, School of Medicine, University of Nottingham, Nottingham, United Kingdom.; NIHR Nottingham Biomedical Research Centre, Biodiscovery Institute, University of Nottingham, Nottingham, United Kingdom., Poulter C; Department of Pediatrics, Queens Medical Centre, Nottingham University Hospitals NHS Trust, Nottingham, United Kingdom., Smyth AR; Lifespan & Population Health, School of Medicine, University of Nottingham, Nottingham, United Kingdom.; NIHR Nottingham Biomedical Research Centre, Biodiscovery Institute, University of Nottingham, Nottingham, United Kingdom., Sharkey D; Centre for Perinatal Research, School of Medicine, University of Nottingham, Nottingham, United Kingdom., Bhatt J; Department of Pediatrics, Queens Medical Centre, Nottingham University Hospitals NHS Trust, Nottingham, United Kingdom., Jenkins G; National Heart and Lung Institute, Imperial College London, London, United Kingdom., Tatler AL; NIHR Nottingham Biomedical Research Centre, Biodiscovery Institute, University of Nottingham, Nottingham, United Kingdom.

Publikováno v: American journal of physiology. Lung cellular and molecular physiology [Am J Physiol Lung Cell Mol Physiol] 2023 Mar 01; Vol. 324 (3), pp. L285-L296. Date of Electronic Publication: 2023 Jan 10.

Asthmatic airway remodeling: long overlooked but too important to ignore.

Autor: Tatler AL; Biodiscovery Institute, School of Medicine, University of Nottingham, Nottingham, UK.

Publikováno v: Annals of translational medicine [Ann Transl Med] 2023 Jan 31; Vol. 11 (2), pp. 29. Date of Electronic Publication: 2022 Dec 07.

Lysyl oxidase like 2 is increased in asthma and contributes to asthmatic airway remodelling.

Autor: Ramis J; Biodiscovery Institute, University of Nottingham, Nottingham, UK.; Dept of Chemical Engineering, Technological Institute of the Philippines, Manila, Philippines., Middlewick R; Centre for Respiratory Research/NIHR Biomedical Research Centre, School of Medicine, University of Nottingham, Nottingham, UK., Pappalardo F; Biodiscovery Institute, University of Nottingham, Nottingham, UK., Cairns JT; Centre for Respiratory Research/NIHR Biomedical Research Centre, School of Medicine, University of Nottingham, Nottingham, UK., Stewart ID; Centre for Respiratory Research/NIHR Biomedical Research Centre, School of Medicine, University of Nottingham, Nottingham, UK.; Margaret Turner Warwick Centre for Fibrosing Lung Disease, National Heart and Lung Institute, Imperial College London, London, UK., John AE; Centre for Respiratory Research/NIHR Biomedical Research Centre, School of Medicine, University of Nottingham, Nottingham, UK.; Margaret Turner Warwick Centre for Fibrosing Lung Disease, National Heart and Lung Institute, Imperial College London, London, UK., Naveed SU; Centre for Respiratory Research/NIHR Biomedical Research Centre, School of Medicine, University of Nottingham, Nottingham, UK.; Institute for Lung Health, Leicester NIHR Biomedical Research Centre, University of Leicester, Leicester, UK., Krishnan R; Center for Vascular Biology Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA., Miller S; Biodiscovery Institute, University of Nottingham, Nottingham, UK.; Centre for Respiratory Research/NIHR Biomedical Research Centre, School of Medicine, University of Nottingham, Nottingham, UK., Shaw DE; Centre for Respiratory Research/NIHR Biomedical Research Centre, School of Medicine, University of Nottingham, Nottingham, UK., Brightling CE; Institute for Lung Health, Leicester NIHR Biomedical Research Centre, University of Leicester, Leicester, UK., Buttery L; Biodiscovery Institute, University of Nottingham, Nottingham, UK., Rose F; Biodiscovery Institute, University of Nottingham, Nottingham, UK., Jenkins G; Centre for Respiratory Research/NIHR Biomedical Research Centre, School of Medicine, University of Nottingham, Nottingham, UK.; Margaret Turner Warwick Centre for Fibrosing Lung Disease, National Heart and Lung Institute, Imperial College London, London, UK., Johnson SR; Biodiscovery Institute, University of Nottingham, Nottingham, UK.; Centre for Respiratory Research/NIHR Biomedical Research Centre, School of Medicine, University of Nottingham, Nottingham, UK., Tatler AL; Centre for Respiratory Research/NIHR Biomedical Research Centre, School of Medicine, University of Nottingham, Nottingham, UK amanda.tatler@nottingham.ac.uk.

Publikováno v: The European respiratory journal [Eur Respir J] 2022 Jul 07; Vol. 60 (1). Date of Electronic Publication: 2022 Jul 07 (Print Publication: 2022).