Synthesis and Comparative Evaluation of Novel Cationic Amphiphile C12-Man-Q as an Efficient DNA Delivery Agent In Vitro

Autor: Gunita Apsite, Irena Timofejeva, Aleksandra Vezane, Brigita Vigante, Martins Rucins, Arkadij Sobolev, Mara Plotniece, Karlis Pajuste, Tatjana Kozlovska, Aiva Plotniece

Publikováno v: Molecules, Vol 23, Iss 7, p 1540 (2018)

New amphiphilic 1,4-DHP derivative C12-Man-Q with remoted cationic moieties at positions 2 and 6 was synthesised to study DNA delivery activity. The results were compared with data obtained for cationic 1,4-DHP derivative D19, which is known to be th

Externí odkaz: https://doaj.org/article/611c777d0f414362a47fcbfe447e4b6d

Comparative protein profiling of B16 mouse melanoma cells susceptible and non-susceptible to alphavirus infection: Effect of the tumor microenvironment

Autor: Dmitry Zhulenvovs, Raimonds Paplausks, Maria Stensland, Tatjana Kozlovska, Baiba Kurena, Gustavo A. de Souza, Jelena Vasilevska, Anna Zajakina, Dace Skrastina

Publikováno v: Cancer Biology & Therapy. 17:1035-1050

Alphavirus vectors are promising tools for cancer treatment. However, relevant entry mechanisms and interactions with host cells are still not clearly understood. The first step toward a more effective therapy is the identification of novel intracell

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f65b3990b1ea1a7cf6ef5cf670ae21b1
https://doi.org/10.1080/15384047.2016.1219813

Design and Synthesis of Small-molecule Hepatitis B Virus Capsid Self-assembly Inhibitors

Autor: Anda Sīpola, Gunārs Duburs, Unda Dubova, Brigita Vīgante, Tatjana Kozlovska, Karīna Spunde

Publikováno v: Proceedings of 3rd International Electronic Conference on Medicinal Chemistry.

An estimated 240 million persons worldwide are chronically infected with hepatitis B virus (HBV). Chronic hepatitis B (CHB) in up to 40% of cases progresses to liver cirrhosis, hepatic decompensation, and hepatocellular carcinoma, a leading cause of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::61ede5a670627f482e810e1c5cb009fc
https://doi.org/10.3390/ecmc-3-04679

The True Story and Advantages of RNA Phage Capsids as Nanotools

Autor: Velta Ose, Paul Pumpens, Andris Dishlers, Kaspars Tars, Martin F. Bachmann, Elmars Grens, Regina Renhofa, Tatjana Kozlovska, Peter Pushko

Publikováno v: Pumpens, Paul; Renhofa, Regina; Dishlers, Andris; Kozlovska, Tatjana; Ose, Velta; Pushko, Peter; Tars, Kaspars; Grens, Elmars; Bachmann, Martin (2016). The True Story and Advantages of RNA Phage Capsids as Nanotools. Intervirology, 59(2), pp. 74-110. Karger 10.1159/000449503

RNA phages are often used as prototypes for modern recombinant virus-like particle (VLP) technologies. Icosahedral RNA phage VLPs can be formed from coat proteins (CPs) and are efficiently produced in bacteria and yeast. Both genetic fusion and chemi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3faf3389996e6327dba079a42b2a14f2

Recombinant Semliki Forest virus vectors encoding hepatitis B virus small surface and pre-S1 antigens induce broadly reactive neutralizing antibodies

Autor: Henrik Garoff, Tatjana Kozlovska, Anna Zajakina, Paul Pumpens, Ruta Bruvere, Wolfram H. Gerlich, A. Bogdanova, Dace Skrastina, Velta Ose, Baiba Niedre-Otomere, Dieter Glebe

Publikováno v: Journal of Viral Hepatitis. 19:664-673

Most hepatitis B virus (HBV) vaccines consist of viral small surface (S) protein subtype adw2 expressed in yeast cells. In spite of good efficacy, HBV-genotype and subtype differences, escape mutants and insufficient Th1 activation remain potential p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6b9429fff8ee294d8e835942f254d9e0
https://doi.org/10.1111/j.1365-2893.2012.01594.x