Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Tatjana Josefs"'
Autor:
Maud Voisin, Elina Shrestha, Claire Rollet, Cyrus A. Nikain, Tatjana Josefs, Mélanie Mahé, Tessa J. Barrett, Hye Rim Chang, Rachel Ruoff, Jeffrey A. Schneider, Michela L. Garabedian, Chris Zoumadakis, Chi Yun, Bara Badwan, Emily J. Brown, Adam C. Mar, Robert J. Schneider, Ira J. Goldberg, Inés Pineda-Torra, Edward A. Fisher, Michael J. Garabedian
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-18 (2021)
Voisin et al. show that reducing phosphorylation at serine 196 of LXRα (LXRα pS196) in hematopoietic cells attenuates atherosclerosis and obesity of mice fed a high-fat diet. They find that the transcriptional activity of LXRα is reprogrammed in m
Externí odkaz:
https://doaj.org/article/c5802b4ff1e54135a67ab96e212ab5fd
Autor:
Jianhua Liu, Noemie Clouet-Foraison, Lesley-Ann Huggins, Jenny E. Kanter, Tomas Vaisar, Karin E. Bornfeldt, Tatjana Josefs, Edward A. Fisher, Debapriya Basu, Jay W. Heinecke, Ira J. Goldberg, Yunying Hu, Britt Arets
Publikováno v:
Circ Res
Circulation Research, 128(6), 690-705. LIPPINCOTT WILLIAMS & WILKINS
Circulation Research, 128(6), 690-705. LIPPINCOTT WILLIAMS & WILKINS
Rationale: Hypertriglyceridemia and low HDL-C (high-density lipoprotein cholesterol), both of which are regulated by LpL (lipoprotein lipase) activity, associate with increased cardiovascular disease. Genetic regulators of LpL actions track with card
Autor:
Yunying Hu, Svetlana Bagdasarov, Jennifer Grossman, Ira J. Goldberg, Tessa J. Barrett, Lesley-Ann Huggins, Diego Scerbo, Namrata Gumaste, Stephanie S. Chiang, Hye Rim Chang, Tatjana Josefs, Edward A. Fisher
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 39:1967-1985
Objective: Fatty acid uptake and oxidation characterize the metabolism of alternatively activated macrophage polarization in vitro, but the in vivo biology is less clear. We assessed the roles of LpL (lipoprotein lipase)-mediated lipid uptake in macr
Autor:
Marleen M.J. van Greevenbroek, Casper G. Schalkwijk, Ira J. Goldberg, Wijtske Annema, Tatjana Josefs, Edward A. Fisher, Coen D.A. Stehouwer, Robin P. F. Dullaart, Carla J.H. van der Kallen, Uwe J. F. Tietge, Tomas Vaisar, Kristiaan Wouters, Ilja C. W. Arts
Publikováno v:
J Clin Lipidol
Journal of Clinical Lipidology, 14(1), 122-132.e4. Elsevier BV
Journal of Clinical Lipidology, 14(1), 122-132.e4. ELSEVIER SCIENCE INC
Journal of Clinical Lipidology, 14(1), 122-132.e4. Elsevier BV
Journal of Clinical Lipidology, 14(1), 122-132.e4. ELSEVIER SCIENCE INC
BACKGROUND: Cholesterol Efflux Capacity (CEC) is considered to be a key atheroprotective property of high-density lipoproteins (HDL). However, the role of HDL-CEC in atherosclerosis and cardiovascular (CV) risk is still controversial, and data in ind
Autor:
Melanie Mahe, Hye Rim Chang, Maud Voisin, Michael J. Garabedian, Adam C. Mar, Ira J. Goldberg, Chi Yun, Cyrus A Nikain, Claire Rollet, Robert J. Schneider, Rachel Ruoff, Chris Zoumadakis, Bara Badwan, Michela L. Garabedian, Emily J. Brown, Elina Shrestha, Tatjana Josefs, Edward A. Fisher, Jeffrey A. Schneider, Tessa J. Barrett, Ines Pineda-Torra
Publikováno v:
Communications Biology
Communications Biology, Vol 4, Iss 1, Pp 1-18 (2021)
Communications Biology, Vol 4, Iss 1, Pp 1-18 (2021)
Atherosclerosis and obesity share pathological features including inflammation mediated by innate and adaptive immune cells. LXRα plays a central role in the transcription of inflammatory and metabolic genes. LXRα is modulated by phosphorylation at
Autor:
Tatjana Josefs, Reinier A. Boon
Publikováno v:
Josefs, T & Boon, R A 2020, ' The Long Non-coding Road to Atherosclerosis ', Current Atherosclerosis Reports, vol. 22, no. 10, 55 . https://doi.org/10.1007/s11883-020-00872-6
Current Atherosclerosis Reports
Current Atherosclerosis Reports
Purpose of Review To summarize recent insights into long non-coding RNAs (lncRNAs) involved in atherosclerosis. Because atherosclerosis is the main underlying pathology of cardiovascular diseases (CVD), the world’s deadliest disease, finding novel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04e82eaa949e61cb3cee003a67b6beb0
https://research.vumc.nl/en/publications/93551087-2fd9-4354-8454-50bfa2d8ae19
https://research.vumc.nl/en/publications/93551087-2fd9-4354-8454-50bfa2d8ae19
Autor:
Maud Voisin, Emily J. Brown, Alexandra Quezada, Xiaoyun Wu, Tessa J. Barrett, Tatjana Josefs, Edward A. Fisher, Jaume Amengual
Publikováno v:
JCI Insight
Neutrophil extracellular traps (NETs) promote inflammation and atherosclerosis progression. NETs are increased in diabetes and impair the resolution of inflammation during wound healing. Atherosclerosis resolution, a process resembling wound healing,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9de7abb583a5643de6e00c3b177c2e53
https://europepmc.org/articles/PMC7205252/
https://europepmc.org/articles/PMC7205252/
Autor:
Emily J. Brown, Maud Voisin, Tatjana Josefs, Edward A. Fisher, Ira J. Goldberg, Michela L. Garabedian, Elina Shrestha, Ines Pineda-Torra, Cyrus A Nikain, Claire Rollet, Hye Rim Chang, Michael J. Garabedian, Rachel Ruoff, Tessa J. Barrett
Atherosclerosis and obesity share pathological features including inflammation mediated by innate and adaptive immune cells. LXRα, a nuclear receptor, plays a central role in the transcription of inflammatory and lipid metabolic genes. LXRα is modu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a4239ec0b57b59e8668886ac664cc12
https://doi.org/10.1101/2020.02.07.939090
https://doi.org/10.1101/2020.02.07.939090
Adipose tissue macrophages induce hepatic neutrophil recruitment and macrophage accumulation in mice
Autor:
José van de Gaar, Maria Vroomen, Ilona Cuijpers, Constantijn J Maalsen, Mitchell Bijnen, Erwin Wijnands, Casper G. Schalkwijk, Marten H. Hofker, Kristiaan Wouters, Erik A.L. Biessen, Tatjana Josefs, Sander S. Rensen, Coen D.A. Stehouwer, Jan Greve
Publikováno v:
Gut, 67(7), 1317-1327. BMJ PUBLISHING GROUP
Gut, 67(7), 1317-1327. BMJ Publishing Group
Gut, 67(7), 1317-1327. BMJ Publishing Group
ObjectiveObesity is a risk factor for non-alcoholic steatohepatitis (NASH). This risk has been attributed to visceral adipose tissue (vAT) expansion associated with increased proinflammatory mediators. Accumulation of CD11c+ proinflammatory adipose t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d74346fd4f1adfd05564eaf235940881
https://research.rug.nl/en/publications/5394fb83-c3b8-4ad1-833f-9ba96cceae44
https://research.rug.nl/en/publications/5394fb83-c3b8-4ad1-833f-9ba96cceae44
Autor:
Robin P. F. Dullaart, Coen D.A. Stehouwer, Tatjana Josefs, Marleen M.J. van Greevenbroek, Kristiaan Wouters, Edward A. Fisher, Ira J. Goldberg, Casper G. Schalkwijk, Carla J.H. van der Kallen, Uwe J. F. Tietge
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 38
Cholesterol Efflux Capacity (CEC) is considered to be a key atheroprotective property of high-density lipoproteins (HDL). However, its role in atherosclerosis risk is still controversial. In this study, we have analyzed the relationship between HDL C