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Autor:
Franz-Josef Meyer-Almes, Christina M. Thiele, Benjamin Horstmann, Michael Korbus, Tatjana Friedmann, Christiane Wolff
Publikováno v:
Bioorganic chemistry. 57
A series of azobenzenealkylmaleimides (AMDs) with different spacer length was synthesized and coupled via Michael-Addition to a specific mutant of a bacterial histone deacetylase-like amidohydrolase (HDAH). Michaelis-Menten parameters (Vmax and Km) w