Swissped-RECOVERY: masked independent adjudication for the interpretation of non-randomised treatment in a two-arm open-label randomised controlled trial (methylprednisolone vs immunoglobulins) in Paediatric Inflammatory Multisystem Syndrome Temporally Associated with SARS-CoV-2 (PIMS-TS) involving 10 secondary and tertiary paediatric hospitals in Switzerland

Autor: Andrew Atkinson, Federica Vanoni, Luregn J Schlapbach, Petra Zimmermann, Alasdair Bamford, Julia Anna Bielicki, Carlos Sánchez, Pablo Rojo, Kate Webb, Michael Buettcher, Johannes Trück, Nina Schöbi, Tatjana Welzel, Adriana Tremoulet, Maya C Andre, Douggl G N Bailey, Geraldine Blanchard-Rohner, Serge Grazioli, Henrik Koehler, Maria-Helena Perez

Publikováno v: BMJ Open, Vol 14, Iss 4 (2024)

Objectives In trials of acute severe infections or inflammations frequent administration of non-randomised treatment (ie, intercurrent event) in response to clinical events is expected. These events may affect the interpretation of trial findings. Sw

Externí odkaz: https://doaj.org/article/15630afce9554366b41c414030826358

Cardiac assessment and inflammatory markers in children with paediatric inflammatory multisystem syndrome temporally associated with SARS-CoV2 (PIMS-TS) treated with methylprednisolone versus intravenous immunoglobulins: 6-month follow-up outcomes of the randomised controlled Swissped RECOVERY trialResearch in context

Autor: Maya C. Andre, Carlos Sanchez, Sabrina Bressieux-Degueldre, Marie-Helene Perez, Daniela Wütz, Geraldine Blanchard-Rohner, Serge Grazioli, Nina Schöbi, Johannes Trück, Tatjana Welzel, Andrew Atkinson, Luregn J. Schlapbach, Julia Bielicki, Henrik Koehler, Spyridoula Gysi, Indra Janz, Andreas Bieri, Birgit Donner, Jürg Hammer, Ulrich Heininger, Clemens von Kalckreuth, Malte Kohns, Nicole Mettauer, Alexandra Meyer, Diana Reppucci, Chloé Schlaeppi, Daniel Trachsel, Nina Vaezipour, Andreas Woerner, Andreas Zutter, Federica Vanoni, Lisa Kottanattu, Calogero Mazzara, Alessia Severi Conti, Christoph Aebi, Philipp Agyeman, Andrea Duppenthaler, Martin Glöckler, Sabine Pallivathukal, Thomas Riedel, Petra Zimmermann, Hong-Phuc Cudré-Cung, Mladen Pavlovic, Alice Bordessoule, Anne-Laure Martin, Angelo Polito, Noemie Wagner, Marie Rohr, Arnaud L'Huillier, Vivianne Amiet, Thomas Ferry, David Longchamp, Julia Natterer, Rebecca Oppenheim, Michael Hofer, Michael Buettcher, Katharina Wechselberger, Alex Donas, Sara Germann, Michaela Lütolf Erni, Daniela Kaiser, Katharina Schwendener Scholl, Hans Peter Kuen, Katja Hrup, Janine Stritt, Douggl G.N. Bailey, Tanja Wachinger, Ingrid Beck, André Birkenmaier, Bjarte Rogdo, Philip Lorenz, Ivo Iglowstein, Konstanze Zöhrer, Martin Flade, Seraina Prader, Jana Pachlopnik Schmid, Michelle Seiler, Patrick Meyer Sauteur, Barbara Brotschi, Kathrin Weber, Elizabeth Whittaker, Saul N. Faust

Publikováno v: EClinicalMedicine, Vol 67, Iss , Pp 102358- (2024)

Summary: Background: Previous findings from the Swissped RECOVERY trial showed that patients with Pediatric Inflammatory Multisystem Syndrome–Temporally Associated with SARS-CoV-2 (PIMS-TS) who were randomly assigned to intravenous immunoglobulins

Externí odkaz: https://doaj.org/article/1d9314edfd444a7c9a33e4b0ed2aafa7

Clinically practical pharmacometrics computer model to evaluate and personalize pharmacotherapy in pediatric rare diseases: application to Graves' disease

Autor: Britta Steffens, Gilbert Koch, Pascal Gächter, Fabien Claude, Verena Gotta, Freya Bachmann, Johannes Schropp, Marco Janner, Dagmar l'Allemand, Daniel Konrad, Tatjana Welzel, Gabor Szinnai, Marc Pfister

Publikováno v: Frontiers in Medicine, Vol 10 (2023)

ObjectivesGraves' disease (GD) with onset in childhood or adolescence is a rare disease (ORPHA:525731). Current pharmacotherapeutic approaches use antithyroid drugs, such as carbimazole, as monotherapy or in combination with thyroxine hormone substit

Externí odkaz: https://doaj.org/article/c3e9c3811567474e91030811eae525aa

Understanding efficacy-safety balance of biologics in moderate-to-severe pediatric psoriasis

Autor: Klervi Golhen, Carolyn Winskill, Martin Theiler, Michael Buettcher, Yu-Hsin Yeh, Nancy Zhang, Tatjana Welzel, Marc Pfister

Publikováno v: Frontiers in Medicine, Vol 9 (2022)

BackgroundPsoriasis is a chronic immune-mediated inflammatory skin disease affecting both adults and children. To better understand the efficacy-safety profile of biologics in children with moderate-to-severe psoriasis, this study aimed to analyze ef

Externí odkaz: https://doaj.org/article/98c69f02a3e94789af81c27ea668292f

Value of Literature Review to Inform Development and Use of Biologics in Juvenile Idiopathic Arthritis

Autor: Klervi Golhen, Carolyn Winskill, Cynthia Yeh, Nancy Zhang, Tatjana Welzel, Marc Pfister

Publikováno v: Frontiers in Pediatrics, Vol 10 (2022)

BackgroundJuvenile idiopathic arthritis (JIA) is one of the most common pediatric inflammatory rheumatic diseases (PiRDs). Uncontrolled disease activity is associated with decreased quality of life and chronic morbidity. Biologic disease-modifying an

Externí odkaz: https://doaj.org/article/049f6a22898341c7a45a9c5570a4749b