Attenuation of intestinal inflammation in IL-10 deficient mice by a plasmid carrying Lactococcus lactis strain

Autor: Meritxell Zurita-Turk, Bianca Mendes Souza, Camila Prósperi de Castro, Vanessa Bastos Pereira, Vanessa Pecini da Cunha, Tatiane Melo Preisser, Ana Maria Caetano de Faria, Denise Carmona Cara Machado, Anderson Miyoshi

Publikováno v: BMC Biotechnology, Vol 20, Iss 1, Pp 1-12 (2020)

Abstract Background Inflammatory bowel diseases (IBD) are intestinal disorders characterized by inflammation in the gastrointestinal tract (GIT) and to date, no efficient treatments exist. Interleukin-10 (IL-10), one of the most important anti-inflam

Externí odkaz: https://doaj.org/article/b00b8c7cdb9a45308fc4fb7000f1fa15

Mycobacterial Hsp65 antigen delivered by invasive Lactococcus lactis reduces intestinal inflammation and fibrosis in TNBS-induced chronic colitis model

Autor: Vanessa Bastos Pereira, Tatiane Melo Preisser, Denise Carmona Cara Machado, Vanessa Pecini da Cunha, Mariana Passos Santana, Anderson Miyoshi

Publikováno v: Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)
Scientific Reports

Intestinal fibrosis associated with Crohn’s disease (CD), which a common and serious complication of inflammatory bowel diseases. In this context, heat shock proteins (HSPs) might serve as an alternative treatment because these antigens play import

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b95312fc105d61c727940e234907012
http://link.springer.com/article/10.1038/s41598-020-77276-8

Lactococcus lactis FNBPA+ (pValac:e6ag85a) Induces Cellular and Humoral Immune Responses After Oral Immunization of Mice

Autor: Janete Soares Coelho dos Santos, Pamela Mancha-Agresti, Sophie Yvette Leclercq, Tatiane Melo Preisser, Vanessa Pecini da Cunha, Vanessa Bastos Pereira, Meritxell Zurita-Turk, Bianca Mendes Souza, Camila Prosperi de Castro, Anderson Miyoshi, Vasco Azevedo

Publikováno v: Frontiers in Microbiology, Vol 12 (2021)
Frontiers in Microbiology

The development of a new vaccine strategy against tuberculosis is urgently needed and has been greatly encouraged by the scientific community worldwide. In this work, we constructed a lactococcal DNA vaccine based on the fusion of two Mycobacterium t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0205a45b3490b866a4f70478511a120
https://www.frontiersin.org/articles/10.3389/fmicb.2021.676172/full

Attenuation of intestinal inflammation in IL-10 deficient mice by a plasmid carrying Lactococcus lactis strain

Autor: Vanessa Bastos Pereira, Tatiane Melo Preisser, Meritxell Zurita-Turk, Anderson Miyoshi, Camila Prosperi de Castro, Bianca Mendes Souza, Ana Maria Caetano Faria, Vanessa Pecini da Cunha, Denise Carmona Cara Machado

Publikováno v: BMC Biotechnology
BMC Biotechnology, Vol 20, Iss 1, Pp 1-12 (2020)

Background Inflammatory bowel diseases (IBD) are intestinal disorders characterized by inflammation in the gastrointestinal tract (GIT) and to date, no efficient treatments exist. Interleukin-10 (IL-10), one of the most important anti-inflammatory cy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4797727667625cebae42daf82e248322
https://doi.org/10.1186/s12896-020-00631-0

Lactococcus lactis carrying the pValac eukaryotic expression vector coding for IL-4 reduces chemically-induced intestinal inflammation by increasing the levels of IL-10-producing regulatory cells

Autor: Ana Maria Caetano Faria, Vanessa Pecini da Cunha, Vasco Azevedo, Denise Carmona Cara Machado, Rafael Pires Oliveira, Jean-Marc Chatel, Tatiane Melo Preisser, Philippe Langella, Bianca Mendes Souza, Vanessa Bastos Pereira, Meritxell Zurita-Turk, Camila Prosperi de Castro, Ana Cristina Gomes-Santos, Anderson Miyoshi

Publikováno v: Microbial Cell Factories
Microbial Cell Factories, BioMed Central, 2016, 15, pp.1-18. ⟨10.1186/s12934-016-0548-x⟩
Microbial Cell Factories (15), 1-18. (2016)

International audience; Background: Inflammatory bowel diseases are characterized by chronic intestinal inflammation that leads to severe destruction of the intestinal mucosa. Therefore, the understanding of their aetiology as well as the development

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::905793a525b6e649307ef953f098cdba