Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Tatiana Y. Zakharian"'
Publikováno v:
Tetrahedron Letters. 51:3645-3648
Synthesis of C 60 –benzenesulfonamide conjugates is reported. The strategies for improving their water solubility, as required for binding to human carbonic anhydrase II, are discussed.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9b9e3f9b8ba9d4ed991daa144ad038a6
https://doi.org/10.1016/j.tetlet.2010.05.017
https://doi.org/10.1016/j.tetlet.2010.05.017
Autor:
Antonios G. Mikos, Anita Saraf, David A. Engler, Preeti Misra, Quynh Pham, Balaji Sitharaman, Jared M. Ashcroft, Lon J. Wilson, Tatiana Y. Zakharian, Su Pan
Publikováno v:
Molecular Pharmaceutics
A new class of water-soluble C60 transfecting agents has been prepared using Hirsch-Bingel chemistry and assessed for their ability to act as gene-delivery vectors in vitro. In an effort to elucidate the relationship between the hydrophobicity of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b2611b5e31acfe26c9862bada5c44fc
http://europepmc.org/articles/PMC2652357
http://europepmc.org/articles/PMC2652357
Autor:
Jiaoyang Jiang, David W. Christianson, Tatiana Y. Zakharian, L. Sangeetha Vedula, David E. Cane
Publikováno v:
Archives of Biochemistry and Biophysics. 469:184-194
Trichodiene synthase from Fusarium sporotrichioides contains two metal ion-binding motifs required for the cyclization of farnesyl diphosphate: the “aspartate-rich” motif D100DXX(D/E) that coordinates to Mg2+A and Mg2+C, and the “NSE/DTE” mot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2bb256247d6d8c65216e3b8d66e014f4
https://doi.org/10.1016/j.abb.2007.10.015
https://doi.org/10.1016/j.abb.2007.10.015
Publikováno v:
Computers & Chemistry. 25:135-144
This paper reports the use of the PM3(tm) semi-empirical method in the Spartan molecular modeling software to optimize geometries and calculate vibrational frequencies for increasingly complex transition metal- and carbon monoxide (CO)-containing sys
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d386b278d130e6f07e31baf2580f42e4
https://doi.org/10.1016/s0097-8485(00)00075-9
https://doi.org/10.1016/s0097-8485(00)00075-9
The binding affinity of (S)-2-amino-6-nitrohexanoic acid to human arginase I was studied using surface plasmon resonance (K(d) = 60 microM), and the X-ray crystal structure of the enzyme-inhibitor complex was determined at 1.6 A resolution to reveal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f452c62638d8410659f83fce0f44cf38
http://hdl.handle.net/11588/768685
http://hdl.handle.net/11588/768685
The synthesis of (2S)-2-amino-7,8-epoxyoctanoic acid is reported along with the X-ray crystal structure of its complex with human arginase I, revealing unique coordination interactions with two manganese ions in the enzyme active site.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::648ac46ed96aded160b10e5aef063f32
http://hdl.handle.net/11588/768655
http://hdl.handle.net/11588/768655
Autor:
Tatiana Y. Zakharian, Lon J. Wilson, R. Bruce Weisman, Jared M. Ashcroft, John W. Marks, Keith B. Hartman, Dmitri A. Tsyboulski, Michael G. Rosenblum
Publikováno v:
ChemInform. 37
The first fullerene (C60) immunoconjugates have been prepared and characterized as an initial step toward the development of fullerene immunotherapy (FIT).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c3e67c397cda2986e9814d0f8fa0aa7
https://doi.org/10.1002/chin.200647219
https://doi.org/10.1002/chin.200647219
Autor:
Tatiana Y. Zakharian, Vernon Knight, Lon J. Wilson, Alexander Seryshev, Brian E. Gilbert, Balaji Sitharaman
Publikováno v:
Journal of the American Chemical Society. 127:12508-12509
A fullerene-paclitaxel conjugate has been synthesized as a slow-release drug for aerosol liposome delivery of paclitaxel for lung cancer therapy. The conjugate was designed to release paclitaxel via enzymatic hydrolysis and subsequently has shown a h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4e6ea5997e6641846302bb75d94e963
https://doi.org/10.1021/ja0546525
https://doi.org/10.1021/ja0546525