Zobrazeno 1 - 10 of 27 pro vyhledávání: '"Tatiana V. Kudryashova"'
1
Akademický článek
GATA6 coordinates cross-talk between BMP10 and oxidative stress axis in pulmonary arterial hypertension
Autor: Tetsuo Toyama, Tatiana V. Kudryashova, Asako Ichihara, Stefania Lenna, Agnieszka Looney, Yuanjun Shen, Lifeng Jiang, Leyla Teos, Theodore Avolio, Derek Lin, Ulas Kaplan, Grace Marden, Vrinda Dambal, Dmitry Goncharov, Horace Delisser, Robert Lafyatis, Francesca Seta, Elena A. Goncharova, Maria Trojanowska
Publikováno v: Scientific Reports, Vol 13, Iss 1, Pp 1-20 (2023)
Abstract Pulmonary arterial hypertension (PAH) is a life-threatening condition characterized by a progressive increase in pulmonary vascular resistance leading to right ventricular failure and often death. Here we report that deficiency of transcript
Externí odkaz: https://doaj.org/article/eaede2ae9a2148b3a1f591eaf455e313
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2
Akademický článek
Single Nucleotide Polymorphism rs9277336 Controls the Nuclear Alpha Actinin 4‐Human Leukocyte Antigen‐DPA1 Axis and Pulmonary Endothelial Pathophenotypes in Pulmonary Arterial Hypertension
Autor: Neha Hafeez, Anna Kirillova, Yunshan Yue, Rashmi J. Rao, Neil J. Kelly, Wadih El Khoury, Yassmin Al Aaraj, Yi‐Yin Tai, Adam Handen, Ying Tang, Danli Jiang, Ting Wu, Yingze Zhang, Dennis McNamara, Tatiana V. Kudryashova, Elena A. Goncharova, Dmitry Goncharov, Thomas Bertero, Mehdi Nouraie, Gang Li, Wei Sun, Stephen Y. Chan
Publikováno v: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 12, Iss 7 (2023)
Background Pulmonary arterial hypertension (PAH) is a complex, fatal disease where disease severity has been associated with the single nucleotide polymorphism (SNP) rs2856830, located near the human leukocyte antigen DPA1 (HLA‐DPA1) gene. We aimed
Externí odkaz: https://doaj.org/article/9664f574fd8840f292c4a425b64c4fd2
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3
Akademický článek
Akt-Dependent Glycolysis-Driven Lipogenesis Supports Proliferation and Survival of Human Pulmonary Arterial Smooth Muscle Cells in Pulmonary Hypertension
Autor: Lifeng Jiang, Dmitry A. Goncharov, Yuanjun Shen, Derek Lin, Baojun Chang, Andressa Pena, Horace DeLisser, Elena A. Goncharova, Tatiana V. Kudryashova
Publikováno v: Frontiers in Medicine, Vol 9 (2022)
Hyper-proliferation of pulmonary arterial vascular smooth muscle cells (PAVSMC) is an important pathological component of pulmonary vascular remodeling in pulmonary arterial hypertension (PAH). Lipogenesis is linked to numerous proliferative diseases
Externí odkaz: https://doaj.org/article/799f9b0d8c38417b80f6504cc3558567
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4
Akademický článek
Differential effects of integrin-linked kinase inhibitor Cpd22 on severe pulmonary hypertension in male and female rats
Autor: Yuanjun Shen, Dmitry A. Goncharov, Theodore Avolio, Arnab Ray, Evelyn Okorie, Horace DeLisser, Ana L. Mora, Rebecca Vanderpool, Tatiana V. Kudryashova, Elena A. Goncharova
Publikováno v: Pulmonary Circulation, Vol 10 (2020)
Pulmonary arterial hypertension (PAH) is a progressive fatal disease with no cure. Inhibition of integrin-linked kinase (ILK) reverses experimental pulmonary hypertension (PH) in male mice, but its effect on severe experimental PH in either male or f
Externí odkaz: https://doaj.org/article/4601f709d4114b24a25bb465d5235762
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7
RAB7 deficiency impairs pulmonary artery endothelial function and promotes pulmonary hypertension
Autor: Bryce Piper, Srimathi Bogamuwa, Tanvir Hossain, Daniela Farkas, Lorena Rosas, Adam Green, Geoffrey Newcomb, Nuo Sun, Jeffrey C. Horowitz, Aneel R Bhagwani, Hu Yang, Tatiana V. Kudryashova, Mauricio Rojas, Ana L. Mora, Pearlly Yan, Rama K. Mallampalli, Elena A. Goncharova, David M. Eckmann, Laszlo Farkas
Publikováno v: bioRxiv
Pulmonary arterial hypertension (PAH) is a devastating and progressive disease with limited treatment options. Endothelial dysfunction plays a central role in development and progression of PAH, yet the underlying mechanisms are incompletely understo
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9640edb699bc62966ed67a5744c80d1
https://europepmc.org/articles/PMC9915659/
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8
Cross-talk between TSC2 and the extracellular matrix controls pulmonary vascular proliferation and pulmonary hypertension
Autor: Yuanjun Shen, Dmitry A. Goncharov, Andressa Pena, Jeffrey Baust, Andres Chavez Barragan, Arnab Ray, Analise Rode, Timothy N. Bachman, Baojun Chang, Lifeng Jiang, Paul Dieffenbach, Laura E. Fredenburgh, Mauricio Rojas, Horace DeLisser, Ana L. Mora, Tatiana V. Kudryashova, Elena A. Goncharova
Publikováno v: Science Signaling. 15
Increased proliferation and survival of cells in small pulmonary arteries (PAs) drive pulmonary arterial hypertension (PAH). Because cell growth mediated by the mTOR-containing mTORC1 complex is inhibited by tuberous sclerosis complex 2 (TSC2), we in
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b02b1d1d539f8af0c3f1210cdee1ad05
https://doi.org/10.1126/scisignal.abn2743
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9
Matrix Metalloproteinase-8 in Pulmonary Hypertension: The Sheep in the Wolf’s Skin?
Autor: Soni Savai Pullamsetti, Elena A. Goncharova, Tatiana V Kudryashova, Giovanni Maroli
Publikováno v: Am J Respir Crit Care Med
RATIONALE: Mechanical signaling through cell–matrix interactions plays a major role in progressive vascular remodeling in pulmonary arterial hypertension (PAH). MMP-8 (matrix metalloproteinase-8) is an interstitial collagenase involved in regulatin
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86541ded0c144417e1d3d5e7ee95d573
https://doi.org/10.1164/rccm.202109-2144ed
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