Výsledky vyhledávání - "Tatiana Ruiz-Larroya"

Helicase Lymphoid-specific enzyme contributes to the maintenance of methylation of SST1 pericentromeric repeats that are frequently demethylated in colon cancer and associated with genomic damage

Autor: Pepita Giménez-Bonafé, Gabrijela Dumbovic, Tatiana Ruiz-Larroya, Sonia-V. Forcales, Johanna K Samuelsson, Andreu Alibés, Cristina Moreta, Cristian Polo, Sergio Alonso, Perucho Manuel

Publikováno v: Dipòsit Digital de la UB
Universidad de Barcelona
Epigenomes; Volume 1; Issue 1; Pages: 2
Recercat. Dipósit de la Recerca de Catalunya
instname
Epigenomes

DNA hypomethylation at repetitive elements accounts for the genome-wide DNA hypomethylation common in cancer, including colorectal cancer (CRC). We identified a pericentromeric repeat element called SST1 frequently hypomethylated (>5% demethylation c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bbb2d45aabfb5505b362268595efee4
http://hdl.handle.net/2445/110282

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Mdm2 antagonists induce apoptosis and synergize with cisplatin overcoming chemoresistance inTP53wild-type ovarian cancer cells

Autor: August Vidal, Avelina Tortosa, Joan Gil, Tatiana Ruiz-Larroya, Fina Martínez-Soler, Alba Pérez-Perarnau, Enric Condom, Roser Mir, Pepita Giménez-Bonafé

Publikováno v: International Journal of Cancer. 132:1525-1536

Ovarian cancer (OVCa) is the leading cause of death from gynecological malignancies. Although treatment for advanced OVCa has improved with the introduction of taxane-platinum chemotherapy, the majority of patients will develop resistance to the trea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e371231a4f191f654b88762e46735f94
https://doi.org/10.1002/ijc.27832

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Frequent somatic demethylation of RAPGEF1/C3G intronic sequences in gastrointestinal and gynecological cancer

Autor: Tak Hong Cheung, Manuel Perucho, Tatiana Ruiz-Larroya, Yick Fu Wong, Sergio Alonso, Johanna Samuelsson

Publikováno v: International Journal of Oncology.

RAPGEF1 (also known as C3G and GRF2) is a guanine nucleotide exchange factor that releases GDP from the inactive Rap1 protein, facilitating its subsequent activation by the binding of GTP. Rap1 plays regulatory roles in proliferation, differentiation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d8702e7ecafd8070c02922531e70eaf
https://doi.org/10.3892/ijo.2011.972

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Abstract 881: Leveraging the molecular heterogeneity of patient-derived tumor samples to simulate clinical trial settings and model combination treatments

Autor: Steve Hoffmaster, Kesavan Nair Praveen, Bhavya Murali, Cyrus Mirsaidi, Kenna Anderes, Thomas Broudy, Tatiana Ruiz-Larroya, Martin Vo, Nicole Streiner

Publikováno v: Cancer Research. 72:881-881

Combination therapy, with rare exception, is a requirement for successfully treating cancer patients. Advances in genetic characterization coupled with a growing understanding of tumor heterogeneity are poised to revolutionize future strategies for c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cf35d8af88e6eb375ce383909df5d35b
https://doi.org/10.1158/1538-7445.am2012-881

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Epigenetic inactivation of the extracellular matrix metallopeptidase ADAMTS19 gene and the metastatic spread in colorectal cancer

Autor: Alex Y. Strongin, Sergio Alonso, Mercedes Durán Domínguez, Pepita Giménez-Bonafé, Takaharu Kato, Tatiana Ruiz-Larroya, Manuel Perucho, Koichi Suzuki, Akihiro Matsunaga, Beatriz González

Publikováno v: Recercat. Dipósit de la Recerca de Catalunya
instname
Digital.CSIC. Repositorio Institucional del CSIC
Clinical Epigenetics
Dipòsit Digital de Documents de la UAB
Universitat Autònoma de Barcelona
Dipòsit Digital de la UB
Universidad de Barcelona
Recercat: Dipósit de la Recerca de Catalunya
Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)

[Background]: ADAMTS19 encodes a member of the ADAMTS (a disintegrin and metalloproteinase domain with thrombospondin motifs) protein family with emerging roles in carcinogenesis and metastasis. ADAMTS shares several distinct protein modules includin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2eb1a077e740b8e946cc0bdf5b7acac3
http://hdl.handle.net/2445/97045

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