An epigenetic association analysis of childhood trauma in psychosis reveals possible overlap with methylation changes associated with PTSD

Autor: Solveig Løkhammer, Anne-Kristin Stavrum, Tatiana Polushina, Monica Aas, Akiah A. Ottesen, Ole A. Andreassen, Ingrid Melle, Stephanie Le Hellard

Publikováno v: Translational Psychiatry, Vol 12, Iss 1, Pp 1-9 (2022)

Abstract Patients with a severe mental disorder report significantly higher levels of childhood trauma (CT) than healthy individuals. Studies have suggested that CT may affect brain plasticity through epigenetic mechanisms and contribute to developin

Externí odkaz: https://doaj.org/article/ef96ef751efc418d8fdd347bb8d5d4e4

Recently evolved human-specific methylated regions are enriched in schizophrenia signals

Autor: Niladri Banerjee, Tatiana Polushina, Francesco Bettella, Sudheer Giddaluru, Vidar M. Steen, Ole A. Andreassen, Stephanie Le Hellard

Publikováno v: BMC Evolutionary Biology, Vol 18, Iss 1, Pp 1-11 (2018)

Abstract Background One explanation for the persistence of schizophrenia despite the reduced fertility of patients is that it is a by-product of recent human evolution. This hypothesis is supported by evidence suggesting that recently-evolved genomic

Externí odkaz: https://doaj.org/article/3a336d4797c84aa3ba6481be2edf197f

87. EXPLORATION OF BRAIN-HERITABLE METHYLATION IN SCHIZOPHRENIA CASES AND CONTROLS

Autor: Leticia Spindola, Tatiana Polushina, Ole Andreassen, Tetyana Zayats, Stephanie Le Hellard

Publikováno v: European Neuropsychopharmacology. 63:e92

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3e11db2db24078a7c69a3b6baf642f01
https://doi.org/10.1016/j.euroneuro.2022.07.172

Identification of pleiotropy at the gene level between psychiatric disorders and related traits

Autor: Markus M. Nöthen, Niladri Banerjee, Thomas Espeseth, Sven Cichon, Tatiana Polushina, Francesco Bettella, Srdjan Djurovic, Stephanie Le Hellard, Sudheer Giddaluru, Ole A. Andreassen, Astri J. Lundervold, Vidar M. Steen, Per Hoffmann

Publikováno v: Translational Psychiatry
Translational Psychiatry 11(1), 410 (2021). doi:10.1038/s41398-021-01530-4
Translational Psychiatry, Vol. 11, No. 1
Translational Psychiatry, Vol 11, Iss 1, Pp 1-9 (2021)

Major mental disorders are highly prevalent and make a substantial contribution to the global disease burden. It is known that mental disorders share clinical characteristics, and genome-wide association studies (GWASs) have recently provided evidenc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::170e5e436c60e6e6d493311880237602
https://pubmed.ncbi.nlm.nih.gov/34326310

Genetic evidence for a role of the SREBP transcription system and lipid biosynthesis in schizophrenia and antipsychotic treatment

Autor: Vidar M. Steen, Ole A. Andreassen, Silje Skrede, Johan Fernø, Tatiana Polushina, Miguel López, Stephanie Le Hellard

Publikováno v: European Neuropsychopharmacology. 27:589-598

Schizophrenia is a serious psychotic disorder, with disabling symptoms and markedly reduced life expectancy. The onset is usually in late adolescence or early adulthood, which in time overlaps with the maturation of the brain including the myelinatio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::942e1a67093504626de1d26a35b1f3ab
https://doi.org/10.1016/j.euroneuro.2016.07.011