Zobrazeno 1 - 10
of 62
pro vyhledávání: '"Tatiana N, Fedorova"'
Long-term Intracerebroventricular Administration of Ouabain Causes Motor Impairments in C57Bl/6 Mice
Autor:
Yulia A. Timoshina, Rogneda B. Kazanskaya, Vladislav A. Zavialov, Anna B. Volnova, Alexander V. Latanov, Tatiana N. Fedorova, Raul R. Gainetdinov, Alexander V. Lopachev
Publikováno v:
Анналы клинической и экспериментальной неврологии, Vol 17, Iss 4, Pp 40-51 (2023)
Introduction. Cardiac glycosides are natural ligands of Na+/K+-ATPase, which regulate its activity and signaling. Intracerebroventricular administration of ouabain has been previously shown to induce hyperlocomotion in C57Bl/6 mice via a decrease in
Externí odkaz:
https://doaj.org/article/3880a927326f4a77992a74e92be8f44e
Autor:
Denis A. Abaimov, Rogneda B. Kazanskaya, Ruslan A. Ageldinov, Maxim S. Nesterov, Yulia A. Timoshina, Angelina I. Platova, Irina J. Aristova, Irina S. Vinogradskaia, Tatiana N. Fedorova, Anna B. Volnova, Raul R. Gainetdinov, Alexander V. Lopachev
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 8, p 4318 (2024)
Cardiotonic steroids (CTSs), such as digoxin, are used for heart failure treatment. However, digoxin permeates the brain–blood barrier (BBB), affecting central nervous system (CNS) functions. Finding a CTS that does not pass through the BBB would i
Externí odkaz:
https://doaj.org/article/74a41d3370b042b2994e81e6eca352c2
Autor:
Alisa A. Markina, Rogneda B. Kazanskaya, Julia A. Timoshina, Vladislav A. Zavialov, Denis A. Abaimov, Anna B. Volnova, Tatiana N. Fedorova, Raul R. Gainetdinov, Alexander V. Lopachev
Publikováno v:
Biomedicines, Vol 11, Iss 7, p 1820 (2023)
In recent years, enough evidence has accumulated to assert that cardiotonic steroids, Na+,K+-ATPase ligands, play an integral role in the physiological and pathophysiological processes in the body. However, little is known about the function of these
Externí odkaz:
https://doaj.org/article/0bb9c854e3214153ba75b60d45fcea51
Autor:
Rogneda B. Kazanskaya, Alexander V. Lopachev, Tatiana N. Fedorova, Raul R. Gainetdinov, Anna B. Volnova
Publikováno v:
HardwareX, Vol 8, Iss , Pp e00120- (2020)
Stereotaxic intracerebral cannula implantation for neuroactive agent administration is a wide-spread method for chronic experiments requiring bypassing the blood-brain barrier in rodents. However, commercially available cannula are bulky and may inte
Externí odkaz:
https://doaj.org/article/16c73cad118e48d4a13973004ade3150
Autor:
Olga M. Lopacheva, Alexander V. Lopachev, Kseniya N. Kulichenkova, Alexander A. Devyatov, Daniil S. Berezhnoy, Sergey L. Stvolinsky, Olga I. Kulikova, Svetlana A. Gavrilova, Mariya P. Morozova, Tatiana N. Fedorova
Publikováno v:
Анналы клинической и экспериментальной неврологии, Vol 12, Iss 1, Pp 38-49 (2018)
Abstract Introduction. Ischemic stroke is one of the most common and socially significant diseases, and its pathogenesis is associated with oxidative stress. The study of mechanisms of the neuroprotective action of the natural antioxidant carnosin
Externí odkaz:
https://doaj.org/article/28f2758b407f469d92066923832dfce7
Autor:
Mariia V. Guryleva, Dmitry V. Chistyakov, Alexander V. Lopachev, Sergei V. Goriainov, Alina A. Astakhova, Yulia A. Timoshina, Anastasiya V. Khutorova, Tatiana N. Fedorova, Marina G. Sergeeva
Publikováno v:
Metabolites, Vol 11, Iss 8, p 498 (2021)
Recently, manipulations with reactive astrocytes have been viewed as a new therapeutic approach that will enable the development of treatments for acute brain injuries and neurodegenerative diseases. Astrocytes can release several substances, which m
Externí odkaz:
https://doaj.org/article/e14a9d2c1ccd4282a1b059e67a724fef
Autor:
Larisa V Smolyaninova, Alexandra A Shiyan, Leonid V Kapilevich, Alexander V Lopachev, Tatiana N Fedorova, Tatiana S Klementieva, Aleksey A Moskovtsev, Aslan A Kubatiev, Sergei N Orlov
Publikováno v:
PLoS ONE, Vol 14, Iss 9, p e0222767 (2019)
It was shown previously that inhibition of the ubiquitous α1 isoform of Na+,K+-ATPase by ouabain sharply affects gene expression profile via elevation of intracellular [Na+]i/[K+]i ratio. Unlike other cells, neurons are abundant in the α3 isoform o
Externí odkaz:
https://doaj.org/article/148a9b22d6e8453586b9fcbe49093f2e
Autor:
Alexander V. Lopachev, Maria A. Lagarkova, Olga S. Lebedeva, Margarita A. Ezhova, Rogneda B. Kazanskaya, Yulia A. Timoshina, Anastasiya V. Khutorova, Evgeny E. Akkuratov, Tatiana N. Fedorova, Raul R. Gainetdinov
Publikováno v:
Brain Sciences, Vol 11, Iss 2, p 203 (2021)
Cardiotonic steroids (CTS) are specific inhibitors and endogenous ligands of a key enzyme in the CNS—the Na+, K+-ATPase, which maintains and creates an ion gradient on the plasma membrane of neurons. CTS cause the activation of various signaling ca
Externí odkaz:
https://doaj.org/article/c049c320f6d847dba09a667e9592305f
Autor:
Nadezhda V. Azbukina, Alexander V. Lopachev, Dmitry V. Chistyakov, Sergei V. Goriainov, Alina A. Astakhova, Vsevolod V. Poleshuk, Rogneda B. Kazanskaya, Tatiana N. Fedorova, Marina G. Sergeeva
Publikováno v:
Metabolites, Vol 10, Iss 6, p 222 (2020)
Wilson’s disease (WD) is a rare autosomal recessive metabolic disorder resulting from mutations in the copper-transporting, P-type ATPase gene ATP7B gene, but influences of epigenetics, environment, age, and sex-related factors on the WD phenotype
Externí odkaz:
https://doaj.org/article/3d611417810d4b699924cd15b89f37b6
Publikováno v:
Amino Acids. 54:1115-1122
l-Carnosine (β-alanyl-l-histidine) is a well-known antioxidant and neuroprotector in various models on animals and cell cultures. However, while there is a plethora of data demonstrating its efficiency as a neuroprotector, there is a distinct lack o