Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Tatiana M. Kazdoba"'
Autor:
Matthew D. Hill, Maria-Jesus Blanco, Francesco G. Salituro, Zhu Bai, Jacob T. Beckley, Michael A. Ackley, Jing Dai, James J. Doherty, Boyd L. Harrison, Ethan C. Hoffmann, Tatiana M. Kazdoba, David Lanzetta, Michael Lewis, Michael C. Quirk, Albert J. Robichaud
Publikováno v:
Journal of Medicinal Chemistry. 65:9063-9075
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::55c17424c1aec1450e3aa6abf75d1774
https://doi.org/10.1021/acs.jmedchem.2c00313
https://doi.org/10.1021/acs.jmedchem.2c00313
Autor:
Matthew D, Hill, Maria-Jesus, Blanco, Francesco G, Salituro, Zhu, Bai, Jacob T, Beckley, Michael A, Ackley, Jing, Dai, James J, Doherty, Boyd L, Harrison, Ethan C, Hoffmann, Tatiana M, Kazdoba, David, Lanzetta, Michael, Lewis, Michael C, Quirk, Albert J, Robichaud
Publikováno v:
Journal of medicinal chemistry. 65(13)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c8abec24ec0551bcb6a6620d33672296
https://pubmed.ncbi.nlm.nih.gov/35785990
https://pubmed.ncbi.nlm.nih.gov/35785990
Autor:
James J. Doherty, Michael A. Ackley, Ethan Hoffmann, Tatiana M. Kazdoba, Zhu Bai, Boyd L. Harrison, Albert J. Robichaud, Andrew Griffin, Mike Lewis, Gabriel Martinez Botella, Francesco G. Salituro, Daniel S. La, Jing Dai, Michael Quirk
Publikováno v:
Journal of Medicinal Chemistry. 62:7526-7542
Neuroactive steroids (NASs) play a pivotal role in maintaining homeostasis is the CNS. We have discovered that one NAS in particular, 24(S)-hydroxycholesterol (24(S)-HC), is a positive allosteric modulator (PAM) of NMDA receptors. Using 24(S)-HC as a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d85c93f6e01f9e02e46c0fd48ba0202c
https://doi.org/10.1021/acs.jmedchem.9b00591
https://doi.org/10.1021/acs.jmedchem.9b00591
Autor:
Tatiana M. Kazdoba, Jennifer M. Parrott, Maya A. Rhine, Jacqueline N. Crawley, Maria N. Schultz
Publikováno v:
Autism Research. 12:401-421
Autism spectrum disorder is a neurodevelopmental syndrome diagnosed primarily by persistent deficits in social interactions and communication, unusual sensory reactivity, motor stereotypies, repetitive behaviors, and restricted interests. No FDA-appr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::36cc72e85a969f1181e26e81d8d5e166
https://doi.org/10.1002/aur.2066
https://doi.org/10.1002/aur.2066
Autor:
Daniel S, La, Francesco G, Salituro, Gabriel, Martinez Botella, Andrew M, Griffin, Zhu, Bai, Michael A, Ackley, Jing, Dai, James J, Doherty, Boyd L, Harrison, Ethan C, Hoffmann, Tatiana M, Kazdoba, Michael C, Lewis, Michael C, Quirk, Albert J, Robichaud
Publikováno v:
Journal of medicinal chemistry. 62(16)
Neuroactive steroids (NASs) play a pivotal role in maintaining homeostasis is the CNS. We have discovered that one NAS in particular, 24(
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8edd1a5945ab2bc16424985f2d7c6fb6
https://pubmed.ncbi.nlm.nih.gov/31390523
https://pubmed.ncbi.nlm.nih.gov/31390523
Autor:
Paul Davies, Albert J. Robichaud, Ethan Hoffmann, James J. Doherty, Tatiana M. Kazdoba, Amit Modgil, Steven M. Gee, Stephen J. Moss, Rebecca S. Hammond, Gabriel M. Belfort, Alison L. Althaus, David P. Nguyen, Jing Dai, Michael Quirk, Francesco G. Salituro, Michael A. Ackley
Publikováno v:
Neuropharmacology. 181:108333
Zuranolone (SAGE-217) is a novel, synthetic, clinical stage neuroactive steroid GABAA receptor positive allosteric modulator designed with the pharmacokinetic properties to support oral daily dosing. In vitro, zuranolone enhanced GABAA receptor curre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::99890c8b94a6266c6c6c30159fa25bcf
https://doi.org/10.1016/j.neuropharm.2020.108333
https://doi.org/10.1016/j.neuropharm.2020.108333
Autor:
Maya A, Rhine, Jennifer M, Parrott, Maria N, Schultz, Tatiana M, Kazdoba, Jacqueline N, Crawley
Publikováno v:
Autism Research
Autism spectrum disorder is a neurodevelopmental syndrome diagnosed primarily by persistent deficits in social interactions and communication, unusual sensory reactivity, motor stereotypies, repetitive behaviors, and restricted interests. No FDA-appr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2f980ff13a2c65d587a7948de0da3000
https://pubmed.ncbi.nlm.nih.gov/30653853
https://pubmed.ncbi.nlm.nih.gov/30653853
Publikováno v:
Genes, Brain and Behavior. 15:7-26
More than a hundred de novo single gene mutations and copy-number variants have been implicated in autism, each occurring in a small subset of cases. Mutant mouse models with syntenic mutations offer research tools to gain an understanding of the rol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b9f9179f4d5503c3d205aa2ee0409763
https://doi.org/10.1111/gbb.12256
https://doi.org/10.1111/gbb.12256
Autor:
Melanie D. Schaffler, Arnold J. Heynen, Mark F. Bear, Jacqueline N. Crawley, Tatiana M. Kazdoba, Laura J. Stoppel, Anthony R. Preza
Publikováno v:
Nature
Neuropsychopharmacology
Neuropsychopharmacology
Human chromosome 16p11.2 microdeletion is among the most common gene copy number variations (CNVs) known to confer risk for intellectual disability (ID) and autism spectrum disorder (ASD) and affects an estimated 3 in 10 000 people. Caused by a singl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::621e57ff53fff628a20b45446f4fd515
https://hdl.handle.net/1721.1/126513
https://hdl.handle.net/1721.1/126513
Publikováno v:
Intractable & Rare Diseases Research. 3:118-133
Fragile X Syndrome (FXS) is a commonly inherited form of intellectual disability and one of the leading genetic causes for autism spectrum disorder. Clinical symptoms of FXS can include impaired cognition, anxiety, hyperactivity, social phobia, and r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b890f1f683ca659c734e80a8e3f39abd
https://doi.org/10.5582/irdr.2014.01024
https://doi.org/10.5582/irdr.2014.01024