Zobrazeno 1 - 10 of 22 pro vyhledávání: '"Tatiana Lipman"'
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Data from Neural Tumor-Initiating Cells Have Distinct Telomere Maintenance and Can be Safely Targeted for Telomerase Inhibition
Autor: Uri Tabori, Peter Dirks, David R. Kaplan, Erin Walker, David Malkin, Robert Tressler, Calvin B. Harley, Ian Clarke, Loen Hansford, Mayumi Fujitani, Tatiana Lipman, Cindy Zhang, Pedro Castelo-Branco
Purpose: Cancer recurrence is one of the major setbacks in oncology. Maintaining telomeres is essential for sustaining the limitless replicative potential of such cancers. Because telomerase is thought to be active in all tumor cells and normal stem
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cc655d08ddd243da295058eee79c530
https://doi.org/10.1158/1078-0432.c.6519174.v1
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5
THOR is a targetable epigenetic biomarker with clinical implications in breast cancer
Autor: Joana Dias Apolónio, João S. Dias, Mónica Teotónio Fernandes, Martin Komosa, Tatiana Lipman, Cindy H. Zhang, Ricardo Leão, Donghyun Lee, Nuno Miguel Nunes, Ana-Teresa Maia, José L. Morera, Luis Vicioso, Uri Tabori, Pedro Castelo-Branco
Background Breast cancer (BC) is the most frequently diagnosed cancer and a leading cause of death among women worldwide. Early BC is potentially curable, but the mortality rates still observed among BC patients demonstrate the urgent need of novel a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb1babf9df3f832af8e826e819670c31
https://hdl.handle.net/10400.1/18744
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6
Combined genetic and epigenetic alterations of the TERT promoter affect clinical and biological behavior of bladder cancer
Autor: Derek Stephens, Cédric Poyet, Ana Melo Gomes, Inês Faleiro, Rashid K. Sayyid, Ricardo Leão, Arnaldo Figueiredo, Cindy Zhang, Peter J. Wild, João Vinagre, Irene Lau, Pedro Castelo-Branco, Tatiana Lipman, Nuno Miguel Nunes, Uri Tabori, Joana Dias Apolónio, Aryeh J. Price, Patrick O. Richard, Nadejda Valtcheva, Girish S. Kulkarni, Kamel Fadaak, Alexandre R. Zlotta, Hugo Coelho, Mathew Mistry, Donghyun Lee, Robert J. Hamilton, Thomas Hermanns, Martin Komosa, Lígia Prado e Castro, Joan Sweet, Kathrin Oehl
Publikováno v: International Journal of Cancer
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
In urothelial bladder cancer (UBC), risk stratification remains an important unmet need. Limitless self‐renewal, governed by TERT expression and telomerase activation, is crucial for cancer progression. Thus, telomerase activation through the inter
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::581324203c47ede87fe7df132a4a4e35
https://doi.org/10.1002/ijc.31935
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IMMU-20. IMMUNE AND TUMOR BIOMARKERS OF OUTCOME IN REPLICATION REPAIR DEFICIENT BRAIN TUMORS TREATED WITH IMMUNE CHECKPOINT INHIBITORS: UPDATES FROM THE INTERNATIONAL REPLICATION REPAIR DEFICIENCY CONSORTIUM
Autor: Sumedha Sudhaman, Eric Bouffet, Valerie Larouche, Deborah T. Blumenthal, Michael Osborn, Stefan S. Bielack, Ayse Bahar Ercan, Duncan Stearns, Cynthia Hawkins, Kim E. Nichols, Lauren Sambira, David Gass, Sandra Luna-Fineman, Charlotta Fröjd, Lindsey Hoffman, Lee Yi Yen, Gregory Thomas, Daniel C. Bowers, Rebecca Loret De Mola, Shlomi Constantini, Anne Bendel, Michael D. Taylor, David S. Ziegler, Tatiana Lipman, Uri Tabori, Scott Lindhorst, An Van Damme, Ted Laetsch, Jeffrey Knipstein, Brittany Campbell, Carol Durno, Gary Mason, Warren P. Mason, Elisabeth Koustenis, Magnus Sabel, David Samuel, Melyssa Aronson, Alyssa Reddy, Michal Oren, Sumita Roy, Patrick Tomboc, Vanan Magimairajan, Daniel Morgenstern, Ira Winer, Jacalyn Kelly, Cindy Zhang, Sara Carroll, Alvaro Lassaletta, Karen Gauvain, G. Rechavi, Stefanie Zimmermann, David Sumerauer, Melissa Edwards, Ailish Coblentz, Kristina A. Cole, Maura Massimino, Oz Mordechai, Nobuko Hijiya, Enrico Opocher, Trevor J. Pugh, Alexander Lossos, Ben George, Adam Shlien, Stefano Chiaravalli, Kami Wolfe Schneider, Margaret E. Wierman, Annika Bronsema, Jiil Chung, Gavin P. Dunn, Michal Zapotocky, M Remke, Santanu Sen, Rina Dvir, Peter B. Dirks
Pediatric brain tumors with replication repair deficiency (RRD) are hypermutant and may respond favorably to immune checkpoint inhibition (ICI). We are collecting ongoing clinical and molecular data from patients with RRD hypermutant cancers treated
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::860de980ca1d4267f20f2495d6848858
https://europepmc.org/articles/PMC6477295/
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IMMU-18. FAVORABLE OUTCOME IN REPLICATION REPAIR DEFICIENT HYPERMUTANT BRAIN TUMORS TO IMMUNE CHECKPOINT INHIBITION: AN INTERNATIONAL RRD CONSORTIUM REGISTRY STUDY
Autor: Duncan Stearns, Rina Dvir, Daniel Morgenstern, Jacalyn Kelly, Ailish Coblentz, Peter B. Dirks, Adam Shlien, Michael Osborn, Nobuko Hijiya, An Van Damme, Gregory Thomas, Anne Bendel, Elisabeth Koustenis, Gavin P. Dunn, Charlotta Fröjd, Sumedha Sudhaman, Lee Yi Yen, Michael D. Taylor, Stefanie Zimmermann, Alexander Lossos, David S. Ziegler, Melyssa Aronson, G. Rechavi, Lauren Sambira, Kami Wolfe Schneider, David Gass, Ben George, Ted Laetsch, Alyssa Reddy, Michal Zapotocky, Eric Bouffet, Cynthia Hawkins, Alberto Broniscer, Scott Lindhorst, Sumita Roy, Patrick Tomboc, Vanan Magimairajan, Maura Massimino, Margaret E. Wierman, Tatiana Lipman, Mark Remke, Karen Gauvain, David Sumerauer, Uri Tabori, Ira Winer, Magnus Sabel, Cindy Zhang, Sara Carroll, Shlomi Constantini, Stefan Bielack, Ayse Bahar Ercan, Valerie Larouche, Stefano Chiaravalli, Lindsey Hoffman, Daniel C. Bowers, Alvaro Lassaletta, Jeffrey Knipstein, Enrico Opocher, Kristina A. Cole, Annika Bronsema, Rebecca Loret De Mola, Jiil Chung, Santanu Sen, Oz Mordechai, Carol Durno, Warren P. Mason, David Samuel, Trevor J. Pugh, Michal Oren, Melissa Edwards, Deborah T. Blumenthal, Sandra Luna-Fineman, Gary Mason
Publikováno v: Neuro-Oncology
Pediatric brain tumors with replication repair deficiency (RRD) are hypermutant and may respond to immune checkpoint inhibition (ICI). We performed a consortium registry study of ICI in recurrent RRD cancers. Clinical and companion biomarkers were co
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff7b7728b9dca83f6bfb63d90d85aee7
http://europepmc.org/articles/PMC7715575
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10
EAPH-06. HYPERMUTANT PEDIATRIC HIGH GRADE GLIOMAS ARE DRIVEN BY RAS/MAPK MUTATIONS AND RESPOND TO MEK INHIBITION
Autor: Tatiana Lipman, Uri Tabori, Daniel Morgenstern, Cynthia Hawkins, Brittany Campbell, Eric Bouffet, Adam Shlien, David Fabrizio
Hypermutant pediatric high grade gliomas (pHGG) constitute 5–10% of PHGG and are almost invariantly caused by replication repair deficiency (RRD). Constitutive activation of the RAS/MAPK pathway via oncogenic mutations can be targeted with MEK inhi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0fa54500c14c7739c5935fb3abeebcf
https://europepmc.org/articles/PMC6012157/
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