Activation of a HIF1alpha-PPARgamma axis underlies the integration of glycolytic and lipid anabolic pathways in pathologic cardiac hypertrophy

Autor: Tatiana Krebs, Allison Felley, Christophe Albert Montessuit, Jean-Claude Perriard, Ellen Aasum, Anna Bogdanova, Renata Windak, Wilhelm Krek, Thierry Pedrazzini, Jaya Krishnan, Malgorzata Tokarska-Schlattner, Marianne Suter, Terje S. Larsen, Evelyne Perriard

Publikováno v: Cell metabolism
Cell Metabolism, Vol. 9, No 6 (2009) pp. 512-524
Cell Metabolism
Cell Metabolism, Elsevier, 2009, 9 (6), pp.512-524. ⟨10.1016/j.cmet.2009.05.005⟩

Development of cardiac hypertrophy and progression to heart failure entails profound changes in myocardial metabolism, characterized by a switch from fatty acid utilization to glycolysis and lipid accumulation. We report that hypoxia-inducible factor

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