Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Tatiana I Shashkova"'
Autor:
Tatiana I. Shashkova, Dmitriy Umerenkov, Mikhail Salnikov, Pavel V. Strashnov, Alina V. Konstantinova, Ivan Lebed, Dmitriy N. Shcherbinin, Marina N. Asatryan, Olga L. Kardymon, Nikita V. Ivanisenko
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
One of the primary tasks in vaccine design and development of immunotherapeutic drugs is to predict conformational B-cell epitopes corresponding to primary antibody binding sites within the antigen tertiary structure. To date, multiple approaches hav
Externí odkaz:
https://doaj.org/article/c3c8b83e19044717be83a4edba248e81
Publikováno v:
PLoS Genetics, Vol 15, Iss 4, p e1008110 (2019)
Varicose veins of lower extremities (VVs) are a common multifactorial vascular disease. Genetic factors underlying VVs development remain largely unknown. Here we report the first large-scale study of VVs performed on a freely available genetic data
Externí odkaz:
https://doaj.org/article/318cf3e8c09d4d02bf3a0a2f3a94c557
Autor:
Maria Sindeeva, Nikolay Chekanov, Manvel Avetisian, Tatiana I Shashkova, Nikita Baranov, Elian Malkin, Alexander Lapin, Olga Kardymon, Veniamin Fishman
Publikováno v:
GigaScience. 12
Interpretation of noncoding genomic variants is one of the most important challenges in human genetics. Machine learning methods have emerged recently as a powerful tool to solve this problem. State-of-the-art approaches allow prediction of transcrip
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aa82e17c3433f8abc54ba1faa94d2e48
https://doi.org/10.1093/gigascience/giad015
https://doi.org/10.1093/gigascience/giad015
Autor:
Dmitriy Umerenkov, Tatiana I. Shashkova, Pavel V. Strashnov, Fedor Nikolaev, Maria Sindeeva, Nikita V. Ivanisenko, Olga L. Kardymon
Accurate prediction of change in protein stability due to point mutations is an attractive goal that remains unachieved. Despite the high interest in this area, little consideration has been given to the transformer architecture, which is dominant in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c249d04c0d5f3d78517daa6294a7393c
https://doi.org/10.1101/2022.12.25.521875
https://doi.org/10.1101/2022.12.25.521875
Autor:
Ivan A. Kuznetsov, Tatiana I. Axenovich, Georgii A. Bazykin, Fyodor A. Kondrashov, Tatiana I. Shashkova, Sergei Slavskii, Yurii S. Aulchenko
Publikováno v:
European Journal of Human Genetics
Adult height inspired the first biometrical and quantitative genetic studies and is a test-case trait for understanding heritability. The studies of height led to formulation of the classical polygenic model, that has a profound influence on the way
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::846391fa899e0d29e6bb06be7c107d46
https://doi.org/10.1038/s41431-021-00836-7
https://doi.org/10.1038/s41431-021-00836-7
Autor:
Lennart C. Karssen, Tatiana I. Shashkova, Peter K. Joshi, Yurii S. Aulchenko, Eugene D Pakhomov, Denis D Gorev
Publikováno v:
Nucleic Acids Research
Shashkova, T I, Pakhomov, E D, Gorev, D D, Karssen, L C, Joshi, P K & Aulchenko, Y S 2020, ' PheLiGe : an interactive database of billions of human genotype-phenotype associations ', Nucleic Acids Research . https://doi.org/10.1093/nar/gkaa1086
Shashkova, T I, Pakhomov, E D, Gorev, D D, Karssen, L C, Joshi, P K & Aulchenko, Y S 2020, ' PheLiGe : an interactive database of billions of human genotype-phenotype associations ', Nucleic Acids Research . https://doi.org/10.1093/nar/gkaa1086
Genome-wide association studies have provided a vast array of publicly available SNP × phenotype association results. However, they are often in disparate repositories and formats, making downstream analyses difficult and time consuming. PheLiGe (ht
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb926753eec069b0b7a101b17ecd9410
https://doi.org/10.1093/nar/gkaa1086
https://doi.org/10.1093/nar/gkaa1086
Autor:
Natalia S. Klimenko, Alexander V. Tyakht, Anna S. Popenko, Anatoly S. Vasiliev, Ilya A. Altukhov, Dmitry S. Ischenko, Tatiana I. Shashkova, Daria A. Efimova, Dmitri A. Nikogosov, Dmitrii A. Osipenko, Sergey V. Musienko, Kseniya S. Selezneva, Ancha Baranova, Alexander M. Kurilshikov, Stepan M. Toshchakov, Aleksei A. Korzhenkov, Nazar I. Samarov, Margarita A. Shevchenko, Alina V. Tepliuk, Dmitry G. Alexeev
Publikováno v:
Nutrients, Vol 10, Iss 5, p 576 (2018)
Personalized nutrition is of increasing interest to individuals actively monitoring their health. The relations between the duration of diet intervention and the effects on gut microbiota have yet to be elucidated. Here we examined the associations o
Externí odkaz:
https://doaj.org/article/2ef8657c3c14495996427570ac5d0901
Autor:
Michel Georges, Jörn Walter, Gilles Gasparoni, Arina Nostaeva, Michael Scherer, Emmanouil T. Dermitzakis, Diana Avalos, Paul A. Lyons, Marion Arnoux, Souad Rahmouni, Thomas Lengauer, Yurii S. Aulchenko, Tatiana I. Shashkova, Edouard Louis
Publikováno v:
Epigenetics & Chromatin
Epigenetics & Chromatin, Vol 14, Iss 1, Pp 1-17 (2021)
Epigenetics & Chromatin, Vol 14, Iss 1, Pp 1-17 (2021)
Funder: Universität des Saarlandes (1036)
Background: Understanding the influence of genetic variants on DNA methylation is fundamental for the interpretation of epigenomic data in the context of disease. There is a need for systematic approach
Background: Understanding the influence of genetic variants on DNA methylation is fundamental for the interpretation of epigenomic data in the context of disease. There is a need for systematic approach
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a0fd794e85f07e94664202242b69460
Autor:
Philipp Khaitovich, Tatiana I. Shashkova, Polina A Ogurtsova, O. V. Kostyunina, Natalia A Zinovieva, Pavel V. Mazin, Artemy A. Shumskiy, Elena Martynova, Asiya F. Ayupova
Publikováno v:
Translational Animal Science
Genomic selection is routinely used worldwide in agricultural breeding. However, in Russia, it is still not used to its full potential partially due to high genotyping costs. The use of genotypes imputed from the low-density chips (LD-chip) provides
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc5363a8bf65952ec821c296a587a462
https://doi.org/10.1093/tas/txz182
https://doi.org/10.1093/tas/txz182
Autor:
Arina Nostaeva, Michael Scherer, Paul A. Lyons, Gilles Gasparoni, Marion Arnoux, Edouard Louis, Thomas Lengauer, Michel Georges, Emmanouil T. Dermitzakis, Souad Rahmouni, Yurii S. Aulchenko, Diana Avalos, Jörn Walter, Tatiana I. Shashkova
BackgroundUnderstanding the influence of genetic variants on DNA methylation is fundamental for the interpretation of epigenomic data in the context of disease. There is a need for systematic approaches not only for determining methylation quantitati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ea44a795fbd91af01e98397917f3515a
https://doi.org/10.1101/2021.05.30.445237
https://doi.org/10.1101/2021.05.30.445237