Use of chitosan as pharmaceutical excipient in ocular drug delivery systems: Sterilization and pharmacokinetics

Autor: Leonardo Lima Fuscaldi, Giselle Foureaux, Simone Odília Antunes Fernandes, Aina Liz Alves Cesar, Juçara R. Franca, Sebastião Cronemberger, Rachel Oliveira Castilho, Anderson J. Ferreira, Valbert Nascimento Cardoso, Tatiana G. Ribeiro, André Augusto Gomes Faraco

Publikováno v: Journal of Biomedical Materials Research Part B: Applied Biomaterials. 108:2227-2237

The use of chitosan as a pharmaceutical excipient in the ocular field is already established. Nevertheless, some aspects related to its ocular administration, such as sterilization and excipient's pharmacokinetics, remain unclear. So, in this study,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::801479dfc11b844ded7cb43670577e28
https://doi.org/10.1002/jbm.b.34560

Antigenicity and protective efficacy of a Leishmania amastigote-specific protein, member of the super-oxygenase family, against visceral leishmaniasis.

Autor: Vivian T Martins, Miguel A Chávez-Fumagalli, Lourena E Costa, Adriana M C Canavaci, Adriana M C C Martins, Paula S Lage, Daniela P Lage, Mariana C Duarte, Diogo G Valadares, Rubens D M Magalhães, Tatiana G Ribeiro, Ronaldo A P Nagem, Wanderson D Darocha, Wiliam C B Régis, Manuel Soto, Eduardo A F Coelho, Ana Paula Fernandes, Carlos A P Tavares

Publikováno v: PLoS Neglected Tropical Diseases, Vol 7, Iss 3, p e2148 (2013)

BackgroundThe present study aimed to evaluate a hypothetical Leishmania amastigote-specific protein (LiHyp1), previously identified by an immunoproteomic approach performed in Leishmania infantum, which showed homology to the super-oxygenase gene fam

Externí odkaz: https://doaj.org/article/1ed48caba5074aee8f85afeec8e6a389

Antileishmanial activity of compounds produced by endophytic fungi derived from medicinal plant Vernonia polyanthes and their potential as source of bioactive substances

Autor: Mariana C. Duarte, Adriana Mendes do Nascimento, Eduardo A.F. Coelho, Mateus Gonçalves Soares, A. M. Nascimento, Paula Souza Lage, Fernanda Karoline Vieira da Silva Torchelsen, Tatiana G. Ribeiro, Jorge Augusto Viana de Araújo, Pedro H.R. Andrade

Publikováno v: World Journal of Microbiology and Biotechnology. 31:1793-1800

The purpose of this work was to evaluate the antileishmanial activity of endophytic fungi isolated from leaves of Vernonia polyanthes plant and their prospective use in the discovery of bioactive compounds. Sixteen endophytes were isolated by using p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3c5370662742c42388e29d1cc96f96d
https://doi.org/10.1007/s11274-015-1932-0

An optimized nanoparticle delivery system based on chitosan and chondroitin sulfate molecules reduces the toxicity of amphotericin B and is effective in treating tegumentary leishmaniasis

Autor: Eduardo A.F. Coelho, Lourena E. Costa, Manuel Soto, Vívian T. Martins, Leonardo Lima Fuscaldi, Mariana C. Duarte, Paula S. Lage, Rachel Oliveira Castilho, Carlos Alberto Pereira Tavares, Valbert Nascimento Cardoso, Simone Odília Antunes Fernandes, Miguel A. Chávez-Fumagalli, Tatiana G. Ribeiro, André Augusto Gomes Faraco, Juçara R. Franca, Mara Lívia dos Santos

Publikováno v: International Journal of Nanomedicine
Digital.CSIC. Repositorio Institucional del CSIC
instname
Biblos-e Archivo. Repositorio Institucional de la UAM

Amphotericin B (AmpB) is active against leishmaniasis, but its use is hampered due to its high toxicity observed in patients. In this study, a nanoparticles-delivery system for AmpB (NQC-AmpB), containing chitosan and chondroitin sulfate molecules, w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c99a97dddc788d21d34987674e00af60
http://europepmc.org/articles/PMC4242406

Chitosan/hydroxyethyl cellulose inserts for sustained-release of dorzolamide for glaucoma treatment: In vitro and in vivo evaluation

Autor: Sebastião Cronemberger, Tatiana G. Ribeiro, José Carlos Nogueira, Simone Odília Antunes Fernandes, Juçara R. Franca, André Augusto Gomes Faraco, Valbert Nascimento Cardoso, Anderson J. Ferreira, Maria Irene Yoshida, Rachel Oliveira Castilho, Leonardo Lima Fuscaldi, Giselle Foureaux

Publikováno v: Repositório Institucional da UFMG
Universidade Federal de Minas Gerais (UFMG)
instacron:UFMG

CNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico FAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais CAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior Eye drops containing hydrophilic drugs

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cbfc9d5dbd23f4de018ea3b3955e0dc
https://doi.org/10.1016/j.ijpharm.2019.118662