Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Tatiana Burrinha"'
Publikováno v:
Bio-Protocol, Vol 7, Iss 23 (2017)
The established primary trigger of Alzheimer’s disease’s is β-amyloid (Aβ) (Mucke and Selkoe, 2012). Amyloid precursor protein (APP) endocytosis is required for Aβ generation at early endosomes (Rajendran and Annaert, 2012). APP retention at e
Externí odkaz:
https://doaj.org/article/14b340b5d006491386db2e6e31572ce5
Publikováno v:
Bio-Protocol, Vol 7, Iss 23 (2017)
Alzheimer’s disease’s established primary trigger is β-amyloid (Aβ) (Mucke and Selkoe, 2012). The amyloid precursor protein (APP) endocytosis is required for Aβ generation at early endosomes (Rajendran and Annaert, 2012). APP retention at endo
Externí odkaz:
https://doaj.org/article/f16374d38d96463b957d35ab46a91832
Autor:
Tatiana Burrinha, César Cunha, Michael J. Hall, Mafalda Lopes‐da‐Silva, Miguel C. Seabra, Cláudia Guimas Almeida
Funding Information: The authors thank the lab members for technical assistance, helpful discussions and for the critical reading of the manuscript. The authors thank Dr. S. Miserey‐Lenkei (Institute Curie), Dr. D. Barral, Dr. O. Vieira and Dr. S.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::daab2b7d4309106adc318333cf107156
https://hdl.handle.net/10362/155155
https://hdl.handle.net/10362/155155
Previously, we found that age-dependent beta-amyloid accumulation is not enough to cause synaptic decline. Here, we characterized endolysosomes (late-endosomes and lysosomes) in aged neurons and the aged brain, which might drive synaptic decline sinc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3d115e60c79afa54034556aa332de5e8
https://doi.org/10.1101/2022.10.12.511921
https://doi.org/10.1101/2022.10.12.511921
Publikováno v:
Current opinion in neurobiology. 73
Neurons live a lifetime. Neuronal aging may increase the risk of Alzheimer's disease. How does neuronal membrane trafficking maintain synapse function during aging? In the normal aged brain, intraneuronal beta-amyloid (Aβ) accumulates without Alzhei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7f5c33519d79c69c1a37501bc0d0894
https://pubmed.ncbi.nlm.nih.gov/35303572
https://pubmed.ncbi.nlm.nih.gov/35303572
Publikováno v:
The Journal of Biological Chemistry
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Funding Information: Funding and additional information—C. G. A. has obtained funding from Maratona da Saúde 2016; CEECIND/00410/2017 financed by FCT (Portugal); ALZ AARG-19–618007 (Alzheimer’s Association); the European Union’s Horizon 2020
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2de6c2693d9bec20fda2c7ec0e76d7c
https://hdl.handle.net/10362/125755
https://hdl.handle.net/10362/125755
Genetics identified BIN1 as the second most important risk locus associated with late-onset Alzheimer’s disease, after APOE4. Here we show the consequences of two coding variants in BIN1 (rs754834233 and rs138047593), both in terms of intracellular
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::26f325b0ead6cfa6c2fe921d30bedc86
https://doi.org/10.1101/2021.06.09.447716
https://doi.org/10.1101/2021.06.09.447716
Autor:
Tatiana Burrinha
Publikováno v:
Journal of Cell Science. 134
First Person is a series of interviews with the first authors of a selection of papers published in Journal of Cell Science, helping early-career researchers promote themselves alongside their papers. Tatiana Burrinha is first author on ‘ Upregulat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3e9a029a975d94206c79b183c48b8d14
https://doi.org/10.1242/jcs.258827
https://doi.org/10.1242/jcs.258827
Autor:
Isak Martinsson, Gunnar K. Gouras, Ricardo Gomes, Ana Paula Terrasso, Claudia G. Almeida, Tatiana Burrinha
Publikováno v:
Journal of Cell Science. 134
Neuronal aging increases the risk of late-onset Alzheimer's disease. During normal aging, synapses decline, and β-amyloid (Aβ) accumulates intraneuronally. However, little is known about the underlying cell biological mechanisms. We studied neurona
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff7fda4e49005d28afd5e3fa59202f4d
https://doi.org/10.1242/jcs.255752
https://doi.org/10.1242/jcs.255752