Long term follow-up of Trypanosoma cruzi infection and Chagas disease manifestations in mice treated with benznidazole or posaconazole.

Autor: Claudia Magalhães Calvet, Tatiana Araújo Silva, Diane Thomas, Brian Suzuki, Ken Hirata, Jair Lage Siqueira-Neto, James H McKerrow

Publikováno v: PLoS Neglected Tropical Diseases, Vol 14, Iss 9, p e0008726 (2020)

Chagas' Disease, caused by the protozoan parasite Trypanosoma cruzi, is responsible for up to 41% of the heart failures in endemic areas in South America and is an emerging infection in regions of North America, Europe, and Asia. Treatment is subopti

Externí odkaz: https://doaj.org/article/1df42a5db86d474e93c1b686655ce8fd

Molecular dissection of Chagas induced cardiomyopathy reveals central disease associated and druggable signaling pathways

Autor: James H. McKerrow, Tatiana Araújo Silva, Claudia M. Calvet, Jair L. Siqueira-Neto, Diane Thomas, David Gonzalez, Jacob M. Wozniak

Publikováno v: PLoS Neglected Tropical Diseases, Vol 14, Iss 5, p e0007980 (2020)
PLoS Neglected Tropical Diseases

Chagas disease, the clinical presentation of T. cruzi infection, is a major human health concern. While the acute phase of Chagas disease is typically asymptomatic and self-resolving, chronically infected individuals suffer numerous sequelae later in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::240c01c39c2732fc78213efe4c716acb
https://doaj.org/article/2a60e80054e049599c289fcae6760c1f

Differential Role of TGF-β in Extracellular Matrix Regulation During Trypanosoma cruzi-Host Cell Interaction

Autor: Luis Felipe de Carvalho Ferreira, Claudia M. Calvet, Tatiana Araújo Silva, Mirian Claudia de Souza Pereira

Publikováno v: International Journal of Molecular Sciences
Volume 20
Issue 19
International Journal of Molecular Sciences, Vol 20, Iss 19, p 4836 (2019)

Transforming growth factor beta (TGF-&beta
) is a determinant for inflammation and fibrosis in cardiac and skeletal muscle in Chagas disease. To determine its regulatory mechanisms, we investigated the response of Trypanosoma cruzi-infected card

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8909334c24eb1b0b2c05b5dd37e87756

Differential Role of TGF-β in Extracellular Matrix Regulation during Trypanosoma cruzi—Host Cell Interaction

Autor: Mirian Claudia de Souza Pereira, Tatiana Araújo Silva, Claudia M. Calvet, Luis Felipe de Carvalho Ferreira

Transforming growth factor beta (TGF-β) is a determinant for inflammation and fibrosis in cardiac and skeletal muscle in Chagas disease. To determine its regulatory mechanisms, we investigated the response of T. cruzi-infected cardiomyocytes (CM), c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1bc669eda0745ba39a37eff4178b97fd
https://doi.org/10.20944/preprints201905.0171.v1

4-aminopyridyl-based lead compounds targeting CYP51 prevent spontaneous parasite relapse in a chronic model and improve cardiac pathology in an acute model of Trypanosoma cruzi infection

Autor: Alanderson R. Nogueira, Brian M. Suzuki, James H. McKerrow, Mirian Claudia de Souza Pereira, Jair L. Siqueira-Neto, Diane Thomas, Ken Hirata, Sharon Lostracco-Johnson, Tatiana Araújo Silva, Claudia M. Calvet, Liliane Batista de Mesquita, Jun Yong Choi, William R. Roush, Larissa M. Podust, Marcelo Meuser-Batista

Publikováno v: PLoS neglected tropical diseases, vol 11, iss 12
PLoS Neglected Tropical Diseases, Vol 11, Iss 12, p e0006132 (2017)
PLoS Neglected Tropical Diseases

Background Chagas disease, caused by the protozoan Trypanosoma cruzi, is the leading cause of heart failure in Latin America. The clinical treatment of Chagas disease is limited to two 60 year-old drugs, nifurtimox and benznidazole, that have variabl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed322f364c649b41057c68ffe4e8af05
https://escholarship.org/uc/item/2c70x8d8