Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Tatiana A. Giovannucci"'
Autor:
Tatiana A. Giovannucci, Florian A. Salomons, Martin Haraldsson, Lotta H. M. Elfman, Malin Wickström, Patrick Young, Thomas Lundbäck, Jürgen Eirich, Mikael Altun, Rozbeh Jafari, Anna-Lena Gustavsson, John Inge Johnsen, Nico P. Dantuma
Publikováno v:
Cell Death and Disease, Vol 12, Iss 10, Pp 1-19 (2021)
Abstract Malignant cells display an increased sensitivity towards drugs that reduce the function of the ubiquitin-proteasome system (UPS), which is the primary proteolytic system for destruction of aberrant proteins. Here, we report on the discovery
Externí odkaz:
https://doaj.org/article/40038c990d214b6aae378be5f01e4f1b
Publikováno v:
Frontiers in Chemistry, Vol 8 (2020)
Instant and adequate handling of misfolded or otherwise aberrant proteins is of paramount importance for maintaining protein homeostasis in cells. The ubiquitin/proteasome system (UPS) is a central player in protein quality control as it operates in
Externí odkaz:
https://doaj.org/article/eb8e439a33534f7aa81da2546577b0eb
Autor:
Rikesh M Rajani, Robert Ellingford, Mariam Hellmuth, Samuel S Harris, Orjona S Taso, David Graykowski, Francesca Kar Wey Lam, Charles Arber, Emre Fertan, John S H Danial, Matthew Swire, Marcus Lloyd, Tatiana A Giovannucci, Mathieu Bourdenx, David Klenerman, Robert Vassar, Selina Wray, Carlo Sala Frigerio, Marc Aurel Busche
Publikováno v:
PLoS Biology, Vol 22, Iss 7, p e3002727 (2024)
Reduction of amyloid beta (Aβ) has been shown to be effective in treating Alzheimer's disease (AD), but the underlying assumption that neurons are the main source of pathogenic Aβ is untested. Here, we challenge this prevailing belief by demonstrat
Externí odkaz:
https://doaj.org/article/2e71a01aa3f9400c837e535979db6d83
Autor:
Tatiana A. Giovannucci, Claire A. Leckey, Randall J. Bateman, Henrik Zetterberg, Kevin Mills, Selina Wray, Ross W. Paterson
Publikováno v:
Alzheimer's & Dementia. 18
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5f827e4f250ee0fe17f14d6770b96690
https://doi.org/10.1002/alz.066080
https://doi.org/10.1002/alz.066080
Autor:
Lara G. Merino, Anne Simonsen, Shanshan Xu, Florian A. Salomons, Maria E. Gierisch, Laura K. Herzog, Martin Haraldsson, Hanna Uvell, Nico P. Dantuma, Anna-Lena Gustavsson, Henriette Stoy, Michaela Vallin, Tatiana A. Giovannucci, Weixing Qian, Alf Håkon Lystad
Publikováno v:
Autophagy. 18(7)
The ubiquitin-proteasome system (UPS) and macroautophagy/autophagy are the main proteolytic systems in eukaryotic cells for preserving protein homeostasis, i.e., proteostasis. By facilitating the timely destruction of aberrant proteins, these complem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfeea9fa181bca01eca342162156b524
https://pubmed.ncbi.nlm.nih.gov/34740308
https://pubmed.ncbi.nlm.nih.gov/34740308
Autor:
Rozbeh Jafari, Mikael Altun, Florian A. Salomons, Patrick Young, Lotta Elfman, Jürgen Eirich, John Inge Johnsen, Malin Wickström, Nico P. Dantuma, Martin Haraldsson, Anna-Lena Gustavsson, Thomas Lundbäck, Tatiana A. Giovannucci
SummaryMalignant cells display an increased sensitivity towards drugs that reduce the function of the ubiquitin-proteasome system (UPS), which is the primary proteolytic system for destruction of aberrant proteins. Here, we report on the discovery of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::56062291d1767b2ec441e74eba7848dd
https://doi.org/10.1101/2021.03.16.435589
https://doi.org/10.1101/2021.03.16.435589
Autor:
Tatiana A. Giovannucci, Florian A. Salomons, Martin Martin Haraldsson, Lotta M.H. Elfman, Malin Wickström, Patrick Young, Thomas Lundbäck, Jürgen Eirich, Mikael Altun, Rozbeh Jafari, Anna-Lena Gustavsson, John Inge Johnsen, Nico Dantuma
Publikováno v:
SSRN Electronic Journal.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3bb8a5131ef07df1282edd6c94afd068
https://doi.org/10.2139/ssrn.3754547
https://doi.org/10.2139/ssrn.3754547
Autor:
Daniela Gödderz, Victoria Menendez-Benito, Nico P. Dantuma, Tatiana A. Giovannucci, Jana Laláková
Publikováno v:
Journal of cell science. 130(19)
The consecutive actions of the ubiquitin-selective segregase Cdc48 and the ubiquitin shuttle factor Rad23 result in the delivery of ubiquitylated proteins at the proteasome. Here, we show that the deubiquitylating enzyme Ubp12 interacts with Cdc48 an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e779b3f336ae97ecd58fc8b2dfd98b2
https://pubmed.ncbi.nlm.nih.gov/28966167
https://pubmed.ncbi.nlm.nih.gov/28966167