Zobrazeno 1 - 10
of 85
pro vyhledávání: '"Tatiana A Gudasheva"'
Autor:
Polina Yu. Povarnina, Anna A. Volkova, Olga N. Vorontsova, Andrey A. Kamensky, Tatiana A. Gudasheva, Sergey B. Seredenin
Publikováno v:
Acta Naturae. 14:94-100
Brain-derived neurotrophic factor (BDNF) is known to be involved in the pathogenesis of Alzheimers disease (AD). However, the pharmacological use of full-length neurotrophin is limited, because of its macromolecular protein nature. A dimeric dipeptid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::92a332bec443622fcd76b7f6249a1cfd
https://doi.org/10.32607/actanaturae.11755
https://doi.org/10.32607/actanaturae.11755
Autor:
Armen G. Mezhlumyan, Anna V. Tallerova, Polina Y. Povarnina, Aleksey V. Tarasiuk, Nellya M. Sazonova, Tatiana A. Gudasheva, Sergey B. Seredenin
Publikováno v:
Pharmaceuticals, Vol 15, Iss 3, p 284 (2022)
Neurotrophins are considered as an attractive target for the development of antidepressants with a novel mechanism of action. Previously, the dimeric dipeptide mimetics of individual loops of nerve growth factor, NGF (GK-6, loop 1; GK-2, loop 4) and
Externí odkaz:
https://doaj.org/article/d59c9dd10e184a8bb8ce4f2d39ea3d64
Autor:
Sergei V. Ivanov, Rita U. Ostrovskaya, Ksenia N. Koliasnikova, Irina B. Alchinova, Marina S. Demorzhi, Tatiana A. Gudasheva, Sergei B. Seredenin
Publikováno v:
Clinical and Experimental Pharmacology and Physiology. 49:1116-1125
Signs of metabolic syndrome and prediabetes preceding type 2 diabetes are modelled in an experiment using a high-fat diet (HFD). The aim of this work was to study the effect of a low molecular weight systemically active nerve growth factor mimetic, c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fda8f746012eff09c9642500df02106c
https://doi.org/10.1111/1440-1681.13693
https://doi.org/10.1111/1440-1681.13693
Autor:
Tatiana A. Gudasheva, Anna V. Tallerova, Armen G. Mezhlumyan, Tatyana A. Antipova, Ilya O. Logvinov, Yulia N. Firsova, Polina Y. Povarnina, Sergey B. Seredenin
Publikováno v:
Biomolecules, Vol 11, Iss 2, p 252 (2021)
A mimetic of the BDNF loop 4, bis (N-monosuccinyl-L-seryl-L-lysine) hexamethylenediamide, named GSB-106, was designed and synthesized in our scientific group. The compound activated TrkB, MAPK/ERK, PI3K/AKT, and PLCγ in in vitro experiments. In vivo
Externí odkaz:
https://doaj.org/article/fd6b301f445d496195370eaf3ae8921a
Autor:
Tatiana A. Gudasheva, Olga A. Deeva, Andrey S. Pantileev, Grigory V. Mokrov, Inna V. Rybina, Milada A. Yarkova, Sergei B. Seredenin
Publikováno v:
Molecules, Vol 25, Iss 21, p 5132 (2020)
The translocator protein (TSPO, 18 kDa) plays an important role in the synthesis of neurosteroids by promoting the transport of cholesterol from the outer to the inner mitochondrial membrane, which is the rate-limiting step in neurosteroidogenesis. S
Externí odkaz:
https://doaj.org/article/07f96a4d06ab4b1eb8a978eeab5971ba
Autor:
N. M. Sazonova, Tatiana A Gudasheva, Andrey D. Durnev, E. M. Grigorevskikh, A. V. Nadorova, L. G. Kolik
Publikováno v:
Bulletin of Experimental Biology and Medicine. 171:441-444
The study examined the effect of GTS-201, a low-molecular weight mimetic of brain-derived neurotrophic factor (BDNF) loop 2, on persistent alcohol craving in outbred male and female albino rats with ethanol preference score ~50% developed in the free
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c8e44ccb40948178e2687efefae38dbf
https://doi.org/10.1007/s10517-021-05245-w
https://doi.org/10.1007/s10517-021-05245-w
Autor:
Tatiana A. Gudasheva, Polina Y. Povarnina, Tatyana A. Antipova, Ilya O. Logvinov, Sergey B. Seredenin
Publikováno v:
Current pharmaceutical design.
Background: A dipeptide mimetic of the BDNF loop 4, bis (N-monosuccinyl-L-seryl-L-lysine) hexamethylenediamide, GSB-106, was designed and synthesized by V.V. Zakusov Research Institute of Pharmacology. The compound activated in vitro TrkB, MAPK/ERK,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::257c32b5b807a9be5d9ee2563ef7585c
https://pubmed.ncbi.nlm.nih.gov/36597610
https://pubmed.ncbi.nlm.nih.gov/36597610
Autor:
A. M. Likhosherstov, Tatiana A Gudasheva, Andrey D. Durnev, I. B. Tsorin, V. V. Barchukov, S. A. Kryzhanovskii, L. G. Kolik, G. V. Mokrov, A. V. Nadorova
Publikováno v:
Bulletin of Experimental Biology and Medicine. 170:763-768
The anxiolytic and analgesic properties of compound ALM-802, a cardiotropic linear methoxyphenyltriazaalkane derivative, combining pharmacophore elements of p-FOX inhibitors trimetazidine and ranolazine were studied in vivo. In the elevated plus-maze
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::af195814a6bd51dd37ea0e7fa9ade435
https://doi.org/10.1007/s10517-021-05149-9
https://doi.org/10.1007/s10517-021-05149-9
Publikováno v:
Current Pharmaceutical Design. 27:217-237
In 2020, it is already 43 years since Braestrup and Squires discovered 18 kDa translocator protein (TSPO), known until 2006 as "peripheral benzodiazepine receptor". During this time, the functions of this receptor, which is located on the outer membr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5467dfe85823f041188b01ce914f13ca
https://doi.org/10.2174/1381612826666200903122025
https://doi.org/10.2174/1381612826666200903122025
Autor:
A. V. Nadorova, N. M. Sazonova, Andrey D. Durnev, E. M. Grigorevskikh, Tatiana A Gudasheva, L. G. Kolik
Publikováno v:
Bulletin of Experimental Biology and Medicine. 171:448-452
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::06c0d97964ad5be9dcfc400898aeab37
https://doi.org/10.47056/0365-9615-2021-171-4-448-452
https://doi.org/10.47056/0365-9615-2021-171-4-448-452