Zobrazeno 1 - 10
of 62
pro vyhledávání: '"Tatiana A, Karakasheva"'
Autor:
Masaru Sasaki, Takeo Hara, Joshua X. Wang, Yusen Zhou, Kanak V. Kennedy, Chizoba N. Umeweni, Maiya A. Alston, Zachary C. Spergel, Satoshi Ishikawa, Ryugo Teranishi, Ritsu Nakagawa, Emily A. Mcmillan, Kelly A. Whelan, Tatiana A. Karakasheva, Kathryn E. Hamilton, Melanie A. Ruffner, Amanda B. Muir
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 17, Iss 6, Pp 923-937 (2024)
Background & Aims: Epithelial disruption in eosinophilic esophagitis (EoE) encompasses both impaired differentiation and diminished barrier integrity. We have shown that lysyl oxidase (LOX), a collagen cross-linking enzyme, is up-regulated in the eso
Externí odkaz:
https://doaj.org/article/4642d52f7d81435797854e2d8c616673
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 17, Iss 5, Pp 713-718 (2024)
Eosinophilic esophagitis (EoE) is an emerging form of food allergy that exerts a significant clinical and financial burden worldwide. EoE is clinically characterized by eosinophil-rich inflammatory infiltrates in esophageal mucosa and esophageal dysf
Externí odkaz:
https://doaj.org/article/cb814a89b8054a00b4aee11f5b159408
Autor:
Tatiana A. Karakasheva, Yusen Zhou, Hongbo M. Xie, Gloria E. Soto, Tiana D. Johnson, Madison A. Stoltz, Daana M. Roach, Noor Nema, Chizoba N. Umeweni, Kaitlyn Naughton, Lauren Dolinsky, James A. Pippin, Andrew D. Wells, Struan F.A. Grant, Louis Ghanem, Natalie Terry, Amanda B. Muir, Kathryn E. Hamilton
Publikováno v:
Gastro Hep Advances, Vol 2, Iss 6, Pp 830-842 (2023)
Background and Aims: A key histopathological feature of inflammatory bowel disease is damage to the mucosa, including breakdown of the epithelial barrier. Human enteroids and colonoids are a critical bench-to-bedside tool for studying the epithelium
Externí odkaz:
https://doaj.org/article/3b5bbb61491c43eda5c548a0bbb7c298
Autor:
Takeo Hara, Yuta Kasagi, Joshua Wang, Masaru Sasaki, Bailey Aaron, Adam Karami, Masataka Shimonosono, Rieko Shimonosono, Hisatsugu Maekawa, Lauren Dolinsky, Benjamin Wilkins, Jeremy Klein, Jane Wei, Kathryn Nunes, Kristle Lynch, Jonathan M. Spergel, Kathryn E. Hamilton, Melanie A. Ruffner, Tatiana A. Karakasheva, Kelly A. Whelan, Hiroshi Nakagawa, Amanda B. Muir
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 13, Iss 5, Pp 1449-1467 (2022)
Background & Aims: Although basal cell hyperplasia is a histologic hallmark of eosinophilic esophagitis (EoE), little is known about the capabilities of epithelial renewal and differentiation in the EoE inflammatory milieu. In murine esophageal epith
Externí odkaz:
https://doaj.org/article/6cf51597b7804a5da4a9fd173aba4b20
Autor:
Tatiana A. Karakasheva, Joel T. Gabre, Uma M. Sachdeva, Ricardo Cruz-Acuña, Eric W. Lin, Maureen DeMarshall, Gary W. Falk, Gregory G. Ginsberg, Zhaohai Yang, Michele M. Kim, Eric S. Diffenderfer, Jason R. Pitarresi, Jinyang Li, Amanda B. Muir, Kathryn E. Hamilton, Hiroshi Nakagawa, Adam J. Bass, Anil K. Rustgi
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
Abstract 3D patient-derived organoids (PDOs) have been utilized to evaluate potential therapies for patients with different cancers. However, the use of PDOs created from treatment-naive patient biopsies for prediction of clinical outcomes in patient
Externí odkaz:
https://doaj.org/article/43bca536a467471b9f4d262b3322f68e
Autor:
Patrick A. Williams, Kaitlyn E. Naughton, Lauren A. Simon, Gloria E. Soto, Louis R. Parham, Xianghui Ma, Charles H. Danan, Weiming Hu, Elliot S. Friedman, Emily A. McMillan, Hritik Mehta, Madison A. Stoltz, Joshua Soto Ocaña, Joseph P. Zackular, Kyle Bittinger, Kelly A. Whelan, Tatiana A. Karakasheva, Kathryn E. Hamilton
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 324:G354-G368
Calorie restriction is associated with enhanced intestinal regeneration after irradiation, but the requirement of autophagy for this process is not known. Our data support the premise that intestinal epithelial autophagy is required for the regenerat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::44fc3763373a94ce9dc3378294b45837
https://doi.org/10.1152/ajpgi.00248.2022
https://doi.org/10.1152/ajpgi.00248.2022
Autor:
Karen J. Dunbar, Tatiana A. Karakasheva, Qiaosi Tang, Gizem Efe, Eric W. Lin, Michael Harris, Varun Sahu, Uma M. Sachdeva, Jianhua Hu, Andres J. Klein-Szanto, Brian Henick, J. Alan Diehl, Hiroshi Nakagawa, Anil K. Rustgi
Publikováno v:
Molecular Cancer Research. :OF1-OF12
Cancer-associated fibroblasts (CAF) can promote tumor growth, metastasis, and therapeutic resistance in esophageal squamous cell carcinoma (ESCC), but the mechanisms of action remain elusive. Our objective was to identify secreted factor(s) that medi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d797a0ee7e68f1d658b45f17b45a616e
https://doi.org/10.1158/1541-7786.mcr-22-0872
https://doi.org/10.1158/1541-7786.mcr-22-0872
Autor:
Anil K. Rustgi, Hiroshi Nakagawa, J. Alan Diehl, Brian Henick, Andres J. Klein-Szanto, Jianhua Hu, Uma M. Sachdeva, Varun Sahu, Michael Harris, Eric W. Lin, Gizem Efe, Qiaosi Tang, Tatiana A. Karakasheva, Karen J. Dunbar
Targeted CCR5 inhibition replicates CCL5 loss with reduced tumor cell proliferation in vitro and in vivo.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e7a3d3e670567eb8f1f072c3d48d8f7
https://doi.org/10.1158/1541-7786.22700254
https://doi.org/10.1158/1541-7786.22700254
Autor:
Anil K. Rustgi, Hiroshi Nakagawa, J. Alan Diehl, Brian Henick, Andres J. Klein-Szanto, Jianhua Hu, Uma M. Sachdeva, Varun Sahu, Michael Harris, Eric W. Lin, Gizem Efe, Qiaosi Tang, Tatiana A. Karakasheva, Karen J. Dunbar
ERK1/2 signaling pathway in CCL5 knockout cells.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0933bb1734d9093ebae053c064ff7727
https://doi.org/10.1158/1541-7786.22700257
https://doi.org/10.1158/1541-7786.22700257
Autor:
Anil K. Rustgi, Hiroshi Nakagawa, J. Alan Diehl, Brian Henick, Andres J. Klein-Szanto, Jianhua Hu, Uma M. Sachdeva, Varun Sahu, Michael Harris, Eric W. Lin, Gizem Efe, Qiaosi Tang, Tatiana A. Karakasheva, Karen J. Dunbar
Loss of tumor-derived CCL5 reduces tumor cell proliferation in TE-1 cells.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ce5da3b6e41b4c3241494e7d8a6d482
https://doi.org/10.1158/1541-7786.22700260
https://doi.org/10.1158/1541-7786.22700260