Compositional differences between Copaxone and Glatopa are reflected in altered immunomodulation ex vivo in a mouse model

Autor: Arthur Komlosh, Kevin Wells-Knecht, Michael R. Hayden, Vera Weinstein, Adrian Gilbert, Attila Konya, Kevin D. Fowler, Revital Krispin, Sarah Kolitz, Sigal Melamed-Gal, Iris Grossman, Pippa S. Loupe, Galia Papir, Yousif Sahly, Benjamin Zeskind, Oren Bar-Ilan, Daphna Laifenfeld, Tal Hasson, Tatiana Molotsky

Publikováno v: Annals of the New York Academy of Sciences. 1407:75-89

Copaxone (glatiramer acetate, GA), a structurally and compositionally complex polypeptide nonbiological drug, is an effective treatment for multiple sclerosis, with a well-established favorable safety profile. The short antigenic polypeptide sequence

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e805a204083fa8717e72cb2f2c739839
https://doi.org/10.1111/nyas.13547

Electronic Structure of G4-DNA by Scanning Tunneling Spectroscopy

Autor: Lior Sagiv, Tatiana Molotsky, Errez Shapir, Rosa Di Felice, Danny Porath, Alexander Kotlyar

Publikováno v: Journal of physical chemistry. C (2010).
info:cnr-pdr/source/autori:Shapir E., L. Sagiv, T. Molotsky, A.B. Kotlyar, R. Di Felice, and D. Porath/titolo:Electronic Structure of G4-DNA by Scanning Tunneling Spectroscopy/doi:/rivista:Journal of physical chemistry. C/anno:2010/pagina_da:/pagina_a:/intervallo_pagine:/volume

G4-DNA molecules were recently reported as candidates for molecular electronics because of their higher stiffness and polarizability with respect to double-stranded DNA. Short G4-DNA structures have been traditionally studied in the past because of t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90788233a97f063606c98f8b852d95ff
https://doi.org/10.1021/jp107952y

High Efficiency of a Sequential Recombinase-Mediated Cassette Exchange Reaction in Escherichia coli

Autor: Natalia Malchin, Tatiana Molotsky, Ilya Borovok, Alexander Kotlyar, Yuri Voziyanov, Ezra Yagil, Mikhail Kolot

Publikováno v: Microbial Physiology. 19:117-122

A comparison between the efficiency of recombinase-mediated cassette exchange (RMCE) reactions catalyzed in Escherichia coli by the site-specific recombinases Flp of yeast and Int of coliphage HK022 has revealed that an Flp-catalyzed RMCE reaction is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::201bc4af82a825a25a8890dac60e4bea
https://doi.org/10.1159/000321497

Synthesis of novel poly(dG)-poly(dG)-poly(dC) triplex structure by Klenow exo- fragment of DNA polymerase I

Autor: Benjamin Dwir, Eli Kapon, Dmitry V. Klinov, Tatiana Molotsky, Natalia Borovok, Alexander Kotlyar

Publikováno v: Nucleic Acids Research

The extension of the G-strand of long (700 bp) poly(dG)-poly(dC) by the Klenow exo(-) fragment of DNA polymerase I yields a complete triplex structure of the H-DNA type. High-performance liquid chromatography analysis demonstrates that the length of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84e5755e333a253465e9275922ec8d23
https://doi.org/10.1093/nar/gki963

In vitro synthesis of uniform poly(dG)-poly(dC) by Klenow exo- fragment of polymerase I

Autor: Michael Gozin, Alexander Kotlyar, Tatiana Molotsky, Ludmila Fadeev, Natalia Borovok

Publikováno v: Nucleic Acids Research

In this paper, we describe a production procedure of the one-to-one double helical complex of poly(dG)-poly(dC), characterized by a well-defined length (up to 10 kb) and narrow size distribution of molecules. Direct evidence of strands slippage durin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::124e153e95eb28fa3a3d2fd45f179ac9
https://doi.org/10.1093/nar/gki178