Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Tatiana, Ivanina"'
Autor:
Sagit Peleg, Ruth Castel, Vladimir Tsemakhovich, Moran Rubinstein, Boaz Styr, Uri Kahanovitch, Galit Tabak, Shai Berlin, Nathan Dascal, Carmen W. Dessauer, Tatiana Ivanina
Publikováno v:
The Journal of Physiology. 592:5373-5390
Key points The G-protein coupled inwardly rectifying potassium (GIRK) channel is an important mediator of neurotransmission via Gβγ subunit of the heterotrimeric Gi/o protein released by G-protein coupled receptor (GPCR) activation. Channels contai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bbe6c83414aca36f5e74c0b4aadee56
https://doi.org/10.1113/jphysiol.2014.283218
https://doi.org/10.1113/jphysiol.2014.283218
Autor:
Vladimir Tsemakhovich, Nathan Dascal, Tal Keren-Raifman, Ruth Castel, Tatiana Ivanina, Shai Berlin, Carmen W. Dessauer
Publikováno v:
Journal of Biological Chemistry. 286:33223-33235
G protein-activated K(+) channels (Kir3 or GIRK) are activated by direct interaction with Gβγ. Gα is essential for specific signaling and regulates basal activity of GIRK (I(basal)) and kinetics of the response elicited by activation by G protein-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af0d9a97998ae6739e8a5ec99aae168b
https://doi.org/10.1074/jbc.m111.271056
https://doi.org/10.1074/jbc.m111.271056
Autor:
Nathan Dascal, Shai Berlin, Tal Keren-Raifman, Moran Rubinstein, Tatiana Ivanina, Ruth Castel, Carmen W. Dessauer
Publikováno v:
Journal of Biological Chemistry. 285:6179-6185
Stable complexes among G proteins and effectors are an emerging concept in cell signaling. The prototypical Gβγ effector G protein-activated K+ channel (GIRK; Kir3) physically interacts with Gβγ but also with Gαi/o. Whether and how Gαi/o subuni
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4fe3bc4d462a90b28a9e0544be8e3439
https://doi.org/10.1074/jbc.m109.085944
https://doi.org/10.1074/jbc.m109.085944
Autor:
Shai Berlin, Nathan Dascal, Sagit Peleg, Moran Rubinstein, Tatiana Ivanina, Dovrat Brass, Carmen W. Dessauer, Tal Keren-Raifman
Publikováno v:
The Journal of Physiology. 587:3473-3491
G protein activated K+ channels (GIRK, Kir3) are switched on by direct binding of Gβγ following activation of Gi/o proteins via G protein-coupled receptors (GPCRs). Although Gαi subunits do not activate GIRKs, they interact with the channels and r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c44f10d56782d0f24c9af8e7d200a340
https://doi.org/10.1113/jphysiol.2009.173229
https://doi.org/10.1113/jphysiol.2009.173229
Autor:
Tal Keren-Raifman, Yuri B. Porozov, Nathan Dascal, Ida Rishal, Tatiana Ivanina, Dalia Varon, Sagit Peleg, Carmen W. Dessauer
Publikováno v:
Journal of Biological Chemistry. 279:17260-17268
G protein-activated K(+) channels (GIRKs; Kir3) are activated by direct binding of Gbetagamma subunits released from heterotrimeric G proteins. In native tissues, only pertussis toxin-sensitive G proteins of the G(i/o) family, preferably Galpha(i3) a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73e0f20ab91aa75fb683f10e717771b1
https://doi.org/10.1074/jbc.m313425200
https://doi.org/10.1074/jbc.m313425200
Autor:
Ida Rishal, Nathan Dascal, Vladlen Z. Slepak, Tal Keren-Raifman, Daniel Yakubovich, Carmen W. Dessauer, Tatiana Ivanina
Publikováno v:
Journal of Biological Chemistry. 278:3840-3845
G protein-gated K+channels (GIRK, or Kir3) are activated by the direct binding of Gβγ or of cytosolic Na+. Na+ activation is fast, Gβγ-independent, and probably via a direct, low affinity (EC50, 30–40 mm) binding of Na+ to the channel. Here we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1e88f069bb4da3f90ee37ad6da75ddc7
https://doi.org/10.1074/jbc.c200605200
https://doi.org/10.1074/jbc.c200605200
Publikováno v:
Neuron. 33(1):87-99
GIRK (Kir3) channels are activated by neurotransmitters coupled to G proteins, via a direct binding of G(beta)(gamma). The role of G(alpha) subunits in GIRK gating is elusive. Here we demonstrate that G(alpha)(i) is not only a donor of G(beta)(gamma)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9dfb3b80409d89129cd55aea1d7ad00
Publikováno v:
Journal of Biological Chemistry. 275:39846-39854
Neuronal voltage-dependent Ca2+channels of the N (α1B) and P/Q (α1A) type are inhibited by neurotransmitters that activate Gi/o G proteins; a major part of the inhibition is voltage-dependent, relieved by depolarization, and results from a direct b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::183c9b4cb35c69c3e600a1ef689d2640
https://doi.org/10.1074/jbc.m005881200
https://doi.org/10.1074/jbc.m005881200
Publikováno v:
Biochemical and Biophysical Research Communications. 274:852-858
By functional coexpression screening of a rat cDNA library in Xenopus oocytes, we have cloned a protein (KCRF: K Channel Regulatory Factor) that reduces currents of several K(+) channels: G protein-activated GIRK1/4 (K(ir)3.1/K(ir)3.4), inward rectif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86dbf25e460c5af5301c988f7a10a561
https://doi.org/10.1006/bbrc.2000.3240
https://doi.org/10.1006/bbrc.2000.3240
Autor:
Nathan Dascal, Yakov Blumenstein, Elena Shistik, Gregory H. Idelson, Tatiana Ivanina, Tal Keren-Raifman
Publikováno v:
Journal of Biological Chemistry. 274:31145-31149
The first 46 amino acids (aa) of the N terminus of the rabbit heart (RH) L-type cardiac Ca(2+) channel alpha(1C) subunit are crucial for the stimulating action of protein kinase C (PKC) and also hinder channel gating (Shistik, E., Ivanina, T., Blumen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::abe579f94f492251dac8af2783115759
https://doi.org/10.1074/jbc.274.44.31145
https://doi.org/10.1074/jbc.274.44.31145