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of 37
pro vyhledávání: '"Tat Fong Ng"'
Autor:
Tat Fong Ng, Jenna Y. Cho, John L. Zhao, John R. Gardiner, Eric S. Wang, Elman Leung, Ziqian Xu, Samantha L. Fineman, Melinda Lituchy, Amy C. Lo, Andrew W. Taylor
Publikováno v:
Biomolecules, Vol 14, Iss 5, p 525 (2024)
Augmenting the natural melanocortin pathway in mouse eyes with uveitis or diabetes protects the retinas from degeneration. The retinal cells are protected from oxidative and apoptotic signals of death. Therefore, we investigated the effects of a ther
Externí odkaz:
https://doaj.org/article/e38c720bd1964cb89befda7ada2673f2
Autor:
Tat Fong Ng, Andrew W. Taylor
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 8, p 6928 (2023)
The endogenous neuropeptide α-Melanocyte Stimulating Hormone (α-MSH) is a potent suppressor of inflammation and has an essential role in maintaining the normal anti-inflammatory microenvironment of the retina. While the therapeutic use of α-MSH pe
Externí odkaz:
https://doaj.org/article/b275f9417b28486fa2032c690382f4f2
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
The ocular tissue microenvironment is immune privileged and uses several mechanisms of immunosuppression to prevent the induction of inflammation. Besides being a blood-barrier and source of photoreceptor nutrients, the retinal pigment epithelial cel
Externí odkaz:
https://doaj.org/article/b1324e7cbaf0459ea23740f33dbea76e
Publikováno v:
Cells, Vol 10, Iss 5, p 1193 (2021)
A central characterization of retinal immunobiology is the prevention of proinflammatory activity by macrophages. The retinal pigment epithelial cells (RPEs) are a major source of soluble anti-inflammatory factors. This includes a soluble factor that
Externí odkaz:
https://doaj.org/article/46dce707f6d246b2bf5921e0d51f8b0a
Publikováno v:
Ocul Immunol Inflamm
(a). PURPOSE. A central neuropeptide mediator of ocular immune privilege is α-MSH, which can be used to therapeutically suppress experimental autoimmune uveitis (EAU). A part of α-MSH-regulation of immune activity is through its melanocortin 5 rece
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Frontiers in Immunology
Frontiers in Immunology
The ocular tissue microenvironment is immune privileged and uses several mechanisms of immunosuppression to prevent the induction of inflammation. Besides being a blood-barrier and source of photoreceptor nutrients, the retinal pigment epithelial cel
Publikováno v:
Cells, Vol 10, Iss 1193, p 1193 (2021)
Cells
Volume 10
Issue 5
Cells
Volume 10
Issue 5
A central characterization of retinal immunobiology is the prevention of proinflammatory activity by macrophages. The retinal pigment epithelial cells (RPEs) are a major source of soluble anti-inflammatory factors. This includes a soluble factor that
Publikováno v:
Exp Eye Res
The melanocortin system plays an essential role in the regulation of immune activity. The anti-inflammatory microenvironment of the eye is dependent on the expression of the melanocortin-neuropeptide alpha-melanocyte stimulating hormone (α-MSH). In
Publikováno v:
ImmunoHorizons
The ocular microenvironment has evolutionarily adapted several mechanisms of immunosuppression to minimize the induction of inflammation. Neuropeptides produced by the retinal pigment epithelial cells regulate macrophage activity. Two neuropeptides,
Autor:
Andrew W. Taylor, Tat Fong Ng
Publikováno v:
Journal of leukocyte biology.
The ocular microenvironment has adapted several negative regulators of inflammation to maintain immune privilege and health of the visual axis. Several constitutively produced negative regulators within the eye TGF-β2, α-melanocyte stimulating horm