Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Tasuku Konno"'
Autor:
Eduardo Pinho Melo, Tasuku Konno, Ilaria Farace, Mosab Ali Awadelkareem, Lise R. Skov, Fernando Teodoro, Teresa P. Sancho, Adrienne W. Paton, James C. Paton, Matthew Fares, Pedro M. R. Paulo, Xin Zhang, Edward Avezov
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)
Aggregation of misfolded proteins underlie dementias. Here, the authors show that stressed cells activate an innate mechanism to resolve aggregates of defective proteins in the endoplasmic reticulum, where a third of cellular proteins are produced.
Externí odkaz:
https://doaj.org/article/604b027e6238474bb516b4dc28bbd629
Autor:
Takenori Kotani, Jajar Setiawan, Tasuku Konno, Noriko Ihara, Saki Okamoto, Yasuyuki Saito, Yoji Murata, Tetsuo Noda, Takashi Matozaki
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
Abstract Cell signaling important for homeostatic regulation of colonic epithelial cells (CECs) remains poorly understood. Mammalian target of rapamycin complex 1 (mTORC1), a protein complex that contains the serine-threonine kinase mTOR, mediates si
Externí odkaz:
https://doaj.org/article/e259b404b0d9467a82163ad3fbd8cc8b
Autor:
Takenori Kotani, Noriko Ihara, Saki Okamoto, Jajar Setiawan, Tasuku Konno, Yasuyuki Saito, Yoji Murata, Takashi Matozaki
Publikováno v:
PLoS ONE, Vol 16, Iss 8, p e0256774 (2021)
Cross talk between different signaling pathways is thought to be important for regulation of homeostasis of, as well as oncogenesis of, the intestinal epithelium. Expression of an active form of K-Ras specifically in intestinal epithelial cells (IECs
Externí odkaz:
https://doaj.org/article/3dc6677168d443738bc23e40aae51d3f
Autor:
Tasuku Konno, Takenori Kotani, Jajar Setiawan, Yuka Nishigaito, Naoki Sawada, Shinya Imada, Yasuyuki Saito, Yoji Murata, Takashi Matozaki
Publikováno v:
PLoS ONE, Vol 14, Iss 4, p e0215255 (2019)
Intestinal epithelial cells (IECs) are regenerated continuously from intestinal stem cells (ISCs) near the base of intestinal crypts in order to maintain homeostasis and structural integrity of intestinal epithelium. Epidermal growth factor (EGF) is
Externí odkaz:
https://doaj.org/article/79f9ee7918c6429f9585682d2e650dc1
Publikováno v:
Cells, Vol 10, Iss 2, p 233 (2021)
Reactive oxygen species (ROS) are produced continuously throughout the cell as products of various redox reactions. Yet these products function as important signal messengers, acting through oxidation of specific target factors. Whilst excess ROS pro
Externí odkaz:
https://doaj.org/article/b4b7ccd9ac4b4d84a11e9b8e177c862a
Autor:
Jung-Ha Park, Takenori Kotani, Tasuku Konno, Jajar Setiawan, Yasuaki Kitamura, Shinya Imada, Yutaro Usui, Naoya Hatano, Masakazu Shinohara, Yasuyuki Saito, Yoji Murata, Takashi Matozaki
Publikováno v:
PLoS ONE, Vol 11, Iss 5, p e0156334 (2016)
The life span of intestinal epithelial cells (IECs) is short (3-5 days), and its regulation is thought to be important for homeostasis of the intestinal epithelium. We have now investigated the role of commensal bacteria in regulation of IEC turnover
Externí odkaz:
https://doaj.org/article/5343b15015534880b56605503cdc2178
Autor:
Satoshi Tsunoda, Edward Avezov, Alisa Zyryanova, Tasuku Konno, Leonardo Mendes-Silva, Eduardo Pinho Melo, Heather P Harding, David Ron
Publikováno v:
eLife, Vol 3 (2014)
Protein folding homeostasis in the endoplasmic reticulum (ER) requires efficient protein thiol oxidation, but also relies on a parallel reductive process to edit disulfides during the maturation or degradation of secreted proteins. To critically exam
Externí odkaz:
https://doaj.org/article/676eee2fd8be4f8abfed0abf85054431
Autor:
Meng Lu, Charles N. Christensen, Jana M. Weber, Tasuku Konno, Nino F. Läubli, Katharina M. Scherer, Edward Avezov, Pietro Lio, Alexei A. Lapkin, Gabriele S. Kaminski Schierle, Clemens F. Kaminski
The ability to quantify structural changes of the endoplasmic reticulum (ER) is crucial for understanding the structure and function of this organelle. However, the rapid movement and complex topology of ER networks make this challenging. Here, we co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::574e05fd2863525c87278e73013f73e6
Autor:
Chyi Wei Chung, Amberley D. Stephens, Tasuku Konno, Edward Ward, Edward Avezov, Clemens F. Kaminski, Ali A. Hassanali, Gabriele S. Kaminski Schierle
Funder: Cambridge Commonwealth, European and International Trust
Funder: Infinitus China Ltd.
The aggregation of Aβ42 is a hallmark of Alzheimer's disease. It is still not known what the biochemical changes are inside a cell which will eve
Funder: Infinitus China Ltd.
The aggregation of Aβ42 is a hallmark of Alzheimer's disease. It is still not known what the biochemical changes are inside a cell which will eve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9f2246a481563df40c9c4be1fe067da
https://www.repository.cam.ac.uk/handle/1810/338539
https://www.repository.cam.ac.uk/handle/1810/338539
Autor:
Meng Lu, Charles N. Christensen, Jana M. Weber, Tasuku Konno, Nino F. Läubli, Katharina M. Scherer, Edward Avezov, Pietro Lio, Alexei A. Lapkin, Gabriele S. Kaminski Schierle, Clemens F. Kaminski
The topology of endoplasmic reticulum (ER) network is highly regulated by various cellular and environmental stimuli and affects major functions such as protein quality control and the cell’s response to metabolic changes. The ability to quantify t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f8251c405246140d9813568cf8f8cc60
https://doi.org/10.1101/2022.05.17.492189
https://doi.org/10.1101/2022.05.17.492189