Výsledky vyhledávání - "Tasuku Kanai"

Akademický článek

Insulin Induces Internalization of the Plasma Membrane 5-Hydroxytryptamine2A (5-HT2A) Receptor in the Isolated Human Endothelium-Denuded Saphenous Vein via the Phosphatidylinositol 3-Kinase Pathway

Autor: Tasuku Kanai, Masachika Kuwabara, Naoko Tanaka-Totoribe, Eisaku Nakamura, Yasuko Matsuo, Shuji Gamoh, Akito Suzuki, Yujiro Asada, Hiroaki Hisa, Ryuichi Yamamoto

Publikováno v: Journal of Pharmacological Sciences, Vol 118, Iss 2, Pp 178-185 (2012)

The aim of this study was to investigate the relaxant effect of insulin on the 5-hydroxytryptamine (5-HT)-induced constriction of the human endothelium-denuded saphenous vein (SV) and its signal transduction pathway. During the 5-HT-induced sustained

Externí odkaz: https://doaj.org/article/a9c200d02b4e4e24925a7308fabc3ad5

Zobrazit plný text záznamu

Akademický článek

Drug Development Targeting the Glycogen Synthase Kinase-3β (GSK-3β)-Mediated Signal Transduction Pathway: The Role of GSK-3β in the Maintenance of Steady-State Levels of Insulin Receptor Signaling Molecules and Nav1.7 Sodium Channel in Adrenal Chromaffin Cells

Autor: Takayuki Nemoto, Toshihiko Yanagita, Tasuku Kanai, Akihiko Wada

Publikováno v: Journal of Pharmacological Sciences, Vol 109, Iss 2, Pp 157-161 (2009)

Glycogen synthase kinase-3 (GSK-3) is constitutively active in nonstimulated cells, where the majority of its substrates undergo inactivation/proteolysis by phosphorylation. Extracellular stimuli (e.g., insulin) catalyze inhibitory Ser9-phosphorylati

Externí odkaz: https://doaj.org/article/c3f1022d80074a6aa2df83625c7fc1b4

Zobrazit plný text záznamu

Endothelin-1-induced down-regulation of NaV1.7 expression in adrenal chromaffin cells: Attenuation of catecholamine secretion and tau dephosphorylation

Autor: Tasuku Kanai, Toshihiko Yanagita, Shinya Satoh, Manabu Murakami, Chihiro Sugita, Takayuki Nemoto, Akihiko Wada, Toyoaki Maruta

Publikováno v: FEBS Letters. 587:898-905

Endothelin-1 and voltage-dependent sodium channels are involved in control and suppression of neuropathological factors, which contribute to sculpting the neuronal network. We previously demonstrated that veratridine-induced NaV1.7 sodium channel act

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cadabd2e6701c3f0978b608d7c093f7e
https://doi.org/10.1016/j.febslet.2013.02.013

Zobrazit plný text záznamu

Insulin Induces Internalization of the Plasma Membrane 5-Hydroxytryptamine2A (5-HT2A) Receptor in the Isolated Human Endothelium-Denuded Saphenous Vein via the Phosphatidylinositol 3-Kinase Pathway

Autor: Masachika Kuwabara, Naoko Tanaka-Totoribe, Eisaku Nakamura, Ryuichi Yamamoto, Yujiro Asada, Tasuku Kanai, Shuji Gamoh, Yasuko Matsuo, Hiroaki Hisa, Akito Suzuki

Publikováno v: Journal of Pharmacological Sciences, Vol 118, Iss 2, Pp 178-185 (2012)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e765bfc612fc5ed17ef9df96e116250c
http://www.sciencedirect.com/science/article/pii/S1347861319305778

Zobrazit plný text záznamu

Homologous posttranscriptional regulation of insulin-like growth factor-I receptor level via glycogen synthase kinase-3β and mammalian target of rapamycin in adrenal chromaffin cells: Effect on tau phosphorylation

Autor: Norie Yoshikawa, Shinya Satoh, Akihiko Wada, Tasuku Kanai, Toshihiko Yanagita, Satoshi Miyazaki, Takayuki Nemoto, Toyoaki Maruta

Publikováno v: Neuropharmacology. 58:1097-1108

In cultured bovine adrenal chromaffin cells, approximately 24 h-treatment with insulin-like growth factor-I (IGF-I) decreased cell surface (125)I-IGF-I binding capacity and IGF-I receptor protein level by approximately 64% (EC(50) = 5.0 nM; t(1/2) =

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8ddc25a549e36f2881b4bfdab3f1d96
https://doi.org/10.1016/j.neuropharm.2010.01.018

Zobrazit plný text záznamu

Chronic lithium treatment up-regulates cell surface NaV1.7 sodium channels via inhibition of glycogen synthase kinase-3 in adrenal chromaffin cells: Enhancement of Na+ influx, Ca2+ influx and catecholamine secretion after lithium withdrawal

Autor: Tasuku Kanai, Toshihiko Yanagita, Takayuki Nemoto, Hideyuki Kobayashi, Shinya Satoh, Kiyotaka Matsuo, Akihiko Wada, Norie Yoshikawa, Yasuhito Uezono, Toyoaki Maruta

Publikováno v: Neuropharmacology. 57:311-321

In cultured bovine adrenal chromaffin cells expressing Na(V)1.7 isoform of voltage-dependent Na(+) channels, we have previously reported that lithium chloride (LiCl) inhibits function of Na(+) channels independent of glycogen synthase kinase-3 (GSK-3

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd817116af57c50e111a14a6f8eedecd
https://doi.org/10.1016/j.neuropharm.2009.05.006

Zobrazit plný text záznamu

Nav1.7 sodium channel-induced Ca2+ influx decreases tau phosphorylation via glycogen synthase kinase-3β in adrenal chromaffin cells

Autor: Toshihiko Yanagita, Tasuku Kanai, Akihiko Wada, Shinya Satoh, Takayuki Nemoto, Toyoaki Maruta, Norie Yoshikawa

Publikováno v: Neurochemistry International. 54:497-505

In cultured bovine adrenal chromaffin cells expressing Na(v)1.7 sodium channel isoform, veratridine increased Ser(473)-phosphorylation of Akt and Ser(9)-phosphorylation of glycogen synthase kinase-3beta by approximately 217 and approximately 195%, wh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9560e59673f4b57dd20f18b67b218f26
https://doi.org/10.1016/j.neuint.2009.02.002

Zobrazit plný text záznamu

Water-soluble jack-knife prawn extract inhibits 5-hydroxytryptamine-induced vasoconstriction and platelet aggregation in humans

Autor: Ryuichi Yamamoto, Tetsuo Yamasaki, Naoko Tanaka-Totoribe, Akiko Watanabe, Eisaku Nakamura, Shuji Gamoh, Masamichi Ohkura, Shouichi Fujimoto, Masahiro Hayashi, Atsuko Yokota, Masachika Kuwabara, Tasuku Kanai

Publikováno v: Foodfunction. 6(2)

Coronary artery spasm plays an important role in the pathogenesis of various ischemic heart diseases or serious arrhythmia. The aim of this study is to look for functional foods which have physiologically active substances preventing 5-hydroxytryptam

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc030417d4e89b0876cf30b8eab2f01b
https://pubmed.ncbi.nlm.nih.gov/25464143

Zobrazit plný text záznamu

The defective protein level of myosin light chain phosphatase (MLCP) in the isolated saphenous vein, as a vascular conduit in coronary artery bypass grafting (CABG), harvested from patients with diabetes mellitus (DM)

Autor: Eisaku Nakamura, Akito Suzuki, Masachika Kuwabara, Shuji Gamoh, Yasuko Matsuo, Tasuku Kanai, Yujiro Asada, Naoko Tanaka-Totoribe, Hiroaki Hisa, Ryuichi Yamamoto

Publikováno v: Biochemical and biophysical research communications. 412(2)

We examined the contractile reactivity to 5-hydroxytryptamine (5-HT) in isolated human saphenous vein (SV), as a vascular conduit in coronary artery bypass grafting (CABG), harvested from patients with diabetes mellitus (DM) and non-DM (NDM). Vascula

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6341bd69e464d479dcf77f51ced49f6
https://pubmed.ncbi.nlm.nih.gov/21821002

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání