Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Tasnim, Chagtai"'
Autor:
Taryn D. Treger, Tasnim Chagtai, Robert Butcher, George D. Cresswell, Reem Al-Saadi, Jesper Brok, Richard D. Williams, Chrissy Roberts, Nicholas M. Luscombe, Kathy Pritchard Jones, William Mifsud
Publikováno v:
Translational Oncology, Vol 11, Iss 6, Pp 1301-1306 (2018)
BACKGROUND: Diffuse anaplastic Wilms tumor (DAWT) is a rare, high-risk subtype that is often missed on diagnostic needle biopsy. Somatic mutations in TP53 are associated with the development of anaplasia and with poorer survival, particularly in adva
Externí odkaz:
https://doaj.org/article/91db7bd722744d7e9972c46a34a8b83c
Autor:
George D. Cresswell, John R. Apps, Tasnim Chagtai, Borbala Mifsud, Christopher C. Bentley, Mariana Maschietto, Sergey D. Popov, Mark E. Weeks, Øystein E. Olsen, Neil J. Sebire, Kathy Pritchard-Jones, Nicholas M. Luscombe, Richard D. Williams, William Mifsud
Publikováno v:
EBioMedicine, Vol 9, Iss C, Pp 120-129 (2016)
The evolution of pediatric solid tumors is poorly understood. There is conflicting evidence of intra-tumor genetic homogeneity vs. heterogeneity (ITGH) in a small number of studies in pediatric solid tumors. A number of copy number aberrations (CNA)
Externí odkaz:
https://doaj.org/article/4d1ac3958e004d7a8acbd60d95ed49f3
Autor:
Kathy Pritchard-Jones, Gordan Vujanic, Chris Jones, Mike Hubank, Ivo Leuschner, Norbert Graf, Jenny Wegert, Manfred Gessler, Neil Sebire, Boo Messahel, Sergey Popov, Tasnim Chagtai, Reem Al-Saadi, Richard D. Williams
Purpose: Wilms' tumor (WT), the most common pediatric renal malignancy, is associated with mutations in several well-characterized genes, most notably WT1, CTNNB1, WTX, and TP53. However, the majority of cases do not harbor mutations in these genes.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5aabcf207397dff234137844acb902ef
https://doi.org/10.1158/1078-0432.c.6519386
https://doi.org/10.1158/1078-0432.c.6519386
Autor:
Kathy Pritchard-Jones, Gordan Vujanic, Chris Jones, Mike Hubank, Ivo Leuschner, Norbert Graf, Jenny Wegert, Manfred Gessler, Neil Sebire, Boo Messahel, Sergey Popov, Tasnim Chagtai, Reem Al-Saadi, Richard D. Williams
Supplementary Data from Subtype-Specific FBXW7 Mutation and MYCN Copy Number Gain in Wilms' Tumor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::594ac882fe908a772d4f2b69b3d98fd1
https://doi.org/10.1158/1078-0432.22442717.v1
https://doi.org/10.1158/1078-0432.22442717.v1
Autor:
Ximena Montano, Cheryl Gillett, Neil J. Sebire, Jack Barton, Tasnim Chagtai, Alex Virasami, Dyanne Rampling, John Anderson, Darren Edwards, G Youssef
Publikováno v:
Human Pathology. 86:182-192
The tumor suppressor TP53 promotes nerve growth factor receptor (NTRK1) -Y674/Y675 phosphorylation (NTRK1-pY674/pY675) via repression of the NTRK1 phosphatase PTPN6 in a ligand-independent manner, resulting in suppression of breast cancer cell prolif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84cbfac622a966f1a48837adc81473b2
https://doi.org/10.1016/j.humpath.2018.12.003
https://doi.org/10.1016/j.humpath.2018.12.003
Autor:
Mariana Maschietto, Richard D Williams, Tasnim Chagtai, Sergey D Popov, Neil J Sebire, Gordan Vujanic, Elizabeth Perlman, James R Anderson, Paul Grundy, Jeffrey S Dome, Kathy Pritchard-Jones
Publikováno v:
PLoS ONE, Vol 9, Iss 10, p e109924 (2014)
The presence of diffuse anaplasia in Wilms tumours (DAWT) is associated with TP53 mutations and poor outcome. As patients receive intensified treatment, we sought to identify whether TP53 mutational status confers additional prognostic information.We
Externí odkaz:
https://doaj.org/article/7e9606e312354327b3a8f617e07771be
Autor:
Kathy Pritchard-Jones, John R. Apps, Marry M. van den Heuvel-Eibrink, Gordan M. Vujanic, Harm van Tinteren, David Gisselsson, Marcel Kool, Sergey Popov, Jenny Wegert, Marisa Alcaide-German, Manfred Gessler, Norbert Graf, Tasnim Chagtai, Richard D. Williams
Publikováno v:
Cancer Research. 75:A1-59
Background and Purpose: Wilms tumor (WT) is the commonest pediatric renal malignancy. A significant minority of cases have mutations in known genes or recurrent copy number aberrations, but few of these have prognostic value. We have previously obser
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b7f981759630e2c357a9d3facd540c6a
https://doi.org/10.1158/1538-7445.transcagen-a1-59
https://doi.org/10.1158/1538-7445.transcagen-a1-59
Autor:
Manfred Gessler, Marcel Kool, Marry M. van den Heuvel-Eibrink, Gordan M. Vujanic, Ivo Leuschner, Norbert Graf, David Gisselsson, Harm van Tinteren, Richard D. Williams, Mariana Maschietto, Peter F. Ambros, Tasnim Chagtai, Christina Zill, Christophe Bergeron, Aurore Coulomb, Linda Dainese, Kathy Pritchard-Jones, Neil J. Sebire, Jenny Wegert, Maureen J. O'Sullivan
Publikováno v:
Cancer Research. 75:A1-67
Background and Purpose: Treatment of Wilms tumor (WT) patients under International Society of Paediatric Oncology (SIOP) protocols is currently stratified by staging and histopathology at nephrectomy after neoadjuvant chemotherapy. However, most rela
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::02a3f9fca47e3b6a2e3e1b0e34faf583
https://doi.org/10.1158/1538-7445.transcagen-a1-67
https://doi.org/10.1158/1538-7445.transcagen-a1-67
Autor:
Harm van Tinteren, Marry M. van den Heuvel-Eibrink, Barbara Ziegler, Peter K. Bode, Matthias Bieg, Ivo Leuschner, Felix Niggli, Marcel Kool, Jenny Wegert, Norbert Graf, Clemens Grimm, Zuguang Gu, Jan Koster, Richard D. Williams, Godelieve A.M. Tytgat, Eckart Meese, Kathy Pritchard-Jones, Sabrina Bausenwein, Tasnim Chagtai, Nicole Ludwig, Susanne Kneitz, Manfred Gessler, Naveed Ishaque, Christina Geörg, Christian Vokuhl, T Acha, Roland Eils, N. Nourkami, Romina Vardapour, Andreas Keller, Maureen J. O'Sullivan, Rogier Versteeg, Stefan M. Pfister, Peter van Sluis, Richard Volckmann
Publikováno v:
Cancer Cell, 27(2), 298-311. Cell Press
Cancer cell, 27(2), 298-311. Cell Press
Cancer cell, 27(2), 298-311. Cell Press
SummaryBlastemal histology in chemotherapy-treated pediatric Wilms tumors (nephroblastoma) is associated with adverse prognosis. To uncover the underlying tumor biology and find therapeutic leads for this subgroup, we analyzed 58 blastemal type Wilms
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed5c451d7ce75835e2a3262d23cf77e4
https://doi.org/10.1016/j.ccell.2015.01.002
https://doi.org/10.1016/j.ccell.2015.01.002
Autor:
Tasnim, Chagtai, Christina, Zill, Linda, Dainese, Jenny, Wegert, Suvi, Savola, Sergey, Popov, William, Mifsud, Gordan, Vujanić, Neil, Sebire, Yves, Le Bouc, Peter F, Ambros, Leo, Kager, Maureen J, O'Sullivan, Annick, Blaise, Christophe, Bergeron, Linda Holmquist, Mengelbier, David, Gisselsson, Marcel, Kool, Godelieve A M, Tytgat, Marry M, van den Heuvel-Eibrink, Norbert, Graf, Harm, van Tinteren, Aurore, Coulomb, Manfred, Gessler, Richard Dafydd, Williams, Kathy, Pritchard-Jones
Publikováno v:
Journal of clinical oncology, 34(26), 3195-3203. American Society of Clinical Oncology
Journal of Clinical Oncology
Journal of Clinical Oncology
Purpose Wilms tumor (WT) is the most common pediatric renal tumor. Treatment planning under International Society of Paediatric Oncology (SIOP) protocols is based on staging and histologic assessment of response to preoperative chemotherapy. Despite
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::c08514350ec0c59cb7e3b983c76f0ab9
https://orca.cardiff.ac.uk/id/eprint/103143/1/jco.2015.66.0001.pdf
https://orca.cardiff.ac.uk/id/eprint/103143/1/jco.2015.66.0001.pdf