Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Tasneem M. Vaid"'
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 21, Iss , Pp 1885-1892 (2023)
A principal challenge in computational modeling of macromolecules is the vast conformational space that arises out of large numbers of atomic degrees of freedom. Recently, growing interest in building predictive models of complexes mediated by Proteo
Externí odkaz:
https://doaj.org/article/bb5e9e9082254c22b23aa4662afe951f
Autor:
Mattia Deluigi, Lena Morstein, Matthias Schuster, Christoph Klenk, Lisa Merklinger, Riley R. Cridge, Lazarus A. de Zhang, Alexander Klipp, Santiago Vacca, Tasneem M. Vaid, Peer R. E. Mittl, Pascal Egloff, Stefanie A. Eberle, Oliver Zerbe, David K. Chalmers, Daniel J. Scott, Andreas Plückthun
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
This study reports the X-ray structure of the α1B-adrenergic G protein-coupled receptor bound to an inverse agonist, and unveils key determinants of subtype-selective ligand binding that may help the design of aminergic drugs with fewer side-effects
Externí odkaz:
https://doaj.org/article/9eae3c81d8e34aff9e67ac17ad3df5fe
Autor:
Lisa M. Williams, Xiaoji He, Tasneem M. Vaid, Alaa Abdul‐Ridha, Alice R. Whitehead, Paul R. Gooley, Ross A.D. Bathgate, Spencer J. Williams, Daniel J. Scott
Publikováno v:
Pharmacology Research & Perspectives, Vol 7, Iss 1, Pp n/a-n/a (2019)
Abstract α1A‐ and α1B‐adrenoceptors (ARs) are G protein‐coupled receptors (GPCRs) that are activated by adrenaline and noradrenaline to modulate smooth muscle contraction in the periphery, and neuronal outputs in the central nervous system (C
Externí odkaz:
https://doaj.org/article/b419ae6ece494556af9fcb4e8297bc83
Publikováno v:
Journal of Computer-Aided Molecular Design. 37:53-65
The Hepatitis C Virus (HCV) NS3/4A is an attractive target for the treatment of Hepatitis C infection. Herein, we present an investigation of HCV NS3/4A inhibitors based on a sulfonamidobenzamide scaffold. Inhibitor interactions with HCV NS3/4A were
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3ddd54a143154f3410ea131b20ac8a2
https://doi.org/10.1007/s10822-022-00490-1
https://doi.org/10.1007/s10822-022-00490-1
Autor:
Jian Wu, Tasneem M. Vaid, Hoshin Kim, Jun Lu, Robel Demissie, Hyun Lee, Leslie W.-M. Fung, Jia Chen, Chenghao Xi, Zhezhou Yang, Yu Huang, Zhantao Zhang, Jingqing Zhang, Fengfeng Yan, Michael E. Johnson, Min Li
Coronavirus infections, such as the global COVID-19 pandemic, have had a profound impact on many aspects of our daily life including working style, economy, and the healthcare system. To prevent the rapid viral transmission and speed up recovery from
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::80b31ffb6a0d6b270b198776851614a7
https://doi.org/10.1101/2023.05.02.539082
https://doi.org/10.1101/2023.05.02.539082
Autor:
Feng-Jie Wu, Fabian Bumbak, Mohammad Hossein Tanipour, Kazem Asadollahi, Tasneem M. Vaid, Ashish Sethi, Daniel J. Scott, Paul R. Gooley
Publikováno v:
NMR Spectroscopy for Probing Functional Dynamics at Biological Interfaces ISBN: 9781839162091
G protein-coupled receptors are the largest family of integral membrane proteins in humans that have roles in almost all physiological processes. The binding of extracellular ligands allosterically modulates the intracellular interaction of the GPCR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::82fa3f5864179deb3a8b081f6a4e90c1
https://doi.org/10.1039/9781839165702-00346
https://doi.org/10.1039/9781839165702-00346
Autor:
Hyun Lee, Isoo Youn, Robel Demissie, Tasneem M. Vaid, Chun-Tao Che, Dimitri T. Azar, Kyu-Yeon Han
Publikováno v:
Bioorganic & Medicinal Chemistry. 85:117289
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fe630465e0a370ab8ad5ee483e1e2cd9
https://doi.org/10.1016/j.bmc.2023.117289
https://doi.org/10.1016/j.bmc.2023.117289
Publikováno v:
Chemistry – A European Journal. 26:11796-11805
The structural poses of ligands that bind weakly to protein receptors are challenging to define. In this work we have studied ligand interactions with the adrenoreceptor (AR) subtypes, α1A -AR and α1B -AR, which belong to the G protein-coupled rece
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::19a3a1de6ef36f4fa0207671a7015981
https://doi.org/10.1002/chem.202000642
https://doi.org/10.1002/chem.202000642
Autor:
Alice R. Whitehead, Fabian Bumbak, Fei Yan, Billy J. Noonan-Williams, Martina Kocan, Shoni Bruell, Tasneem M. Vaid, Daniel Scott, Trayder Thomas, Ross A. D. Bathgate, David K. Chalmers, Margaret A. Johnson, Xuan Tan, Paul R. Gooley
Publikováno v:
ACS Pharmacol Transl Sci
[Image: see text] Cell–cell communication via endogenous peptides and their receptors is vital for controlling all aspects of human physiology and most peptides signal through G protein-coupled receptors (GPCRs). Disordered peptides bind GPCRs thro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::293f5d2c513f0cc707f407e20d4af9db
https://doi.org/10.1021/acsptsci.0c00026
https://doi.org/10.1021/acsptsci.0c00026
One of the principal difficulties in computational modeling of macromolecules is the vast conformational space that arises out of large numbers of atomic degrees of freedom. This problem is a familiar issue in the area of protein-protein docking, whe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81562322a974889538372e2465a59882
https://doi.org/10.1101/2021.08.31.458424
https://doi.org/10.1101/2021.08.31.458424