Zobrazeno 1 - 10 of 52 pro vyhledávání: '"Tasneem A. Khwaja"'
1
In silico modulation of apoptotic Bcl-2 proteins by mistletoe lectin-1: functional consequences of protein modifications
Autor: Nasir-Ud Nasir-Ud Din, Abdul Rauf Shakoori, Tayyaba Wajahat, Ishtiaq Ahmad, Tasneem A. Khwaja, Evelyne Walker-Nasir, Daniel C. Hoessli, Afshan Kaleem, Wajahat M. Qazi
Publikováno v: Journal of cellular biochemistry, Vol. 103, No 2 (2008) pp. 479-91
The mistletoe lectin-1 (ML-1) modulates tumor cell apoptosis by triggering signaling cascades through the complex interplay of phosphorylation and O-linked N-acetylglucosamine (O-GlcNAc) modification in pro- and anti-apoptotic proteins. In particular
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf2b62c084c4e7372047d977be06dea6
https://archive-ouverte.unige.ch/unige:2489
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3
Structure-activity relationships of antineoplastic agents in multidrug resistance
Autor: Corwin Hansch, Tasneem A. Khwaja, Cynthia Dias Selassie
Publikováno v: Journal of medicinal chemistry. 33(7)
Clinical resistance to many antineoplastic agents is a major cause of treatment failure. The well-documented phenomenon addressed as multidrug resistance (MDR) allows cells to withstand exposure to lethal doses of drugs with dissimilar chemical struc
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a1411693f430116d54d6f52324b7122
https://pubmed.ncbi.nlm.nih.gov/2362268
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4
Comparative structure-activity relationships of antifolate triazines inhibiting murine tumor cells sensitive and resistant to methotrexate
Autor: Stephanie Pentecost, Corwin Hansch, Cecilia B. Dias, Tasneem A. Khwaja, Cynthia Dias Selassie
Publikováno v: Journal of Medicinal Chemistry. 27:347-357
The inhibitory effect of 108 4,6-diamino-1,2-dihydro-2,2-dimethyl-1-(substituted-phenyl)-s-triazines on murine L5178Y tumor cells, resistant and sensitive to methotrexate (MTX), has been studied. From the pI50 values, quantitative structure-activity
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6359f7ca5807bc9d4c0dc0231a54fcd3
https://doi.org/10.1021/jm00369a019
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5
Adjuvant postoperative chemotherapy with 5-fluorouracil and methotrexate: Effect of schedule of administration on metastasis of 13762 mammary adenocarcinoma
Autor: Tasneem A. Khwaja, Yeu-tsu N. Lee
Publikováno v: Journal of Surgical Oncology. 9:469-479
Metastasizing mammary adenocarcinoma 13762 in female Fischer rats has been used as a model for studying postoperative adjuvant chemotherapy, using methotrexate (Mtx) and 5-fluorouracil (5FU) either singly or in combinations. All animals that received
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1ed93e31acb50522b5c275847eafff7
https://doi.org/10.1002/jso.2930090509
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6
Response of lymphoid leukemia L1210 in mice to implantable sustained release cytosine arabinoside capsules
Autor: J. C. Fu, D. L. Moyer, D. Elshire, Tasneem A. Khwaja, J. Varvan, L. Cummings
Publikováno v: Journal of Surgical Oncology. 10:1-7
The lifespan of BDF mice with ascitic L1210 leukemia is more than doubled when they are treated with a single subcutaneously or intraperitoneally implanted sustained release cytosine arabinoside capsule. These capsules are drug-polymer composites, wi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ecf13d80a3b7a08496159d404f85144
https://doi.org/10.1002/jso.2930100102
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8
Synthesis and antitumor and antiviral activities of 1-.beta.-D-arabinofuranosyl-2-amino-1,4(2H)-iminopyrimidine, and its derivatives
Autor: Robert A. Long, Robert W. Sidwell, Tasneem A. Khwaja, A. Mohsin Mian, Lois B. Allen, Roland K. Robins
Publikováno v: Journal of Medicinal Chemistry. 22:514-518
1-beta-D-Arabinofuranosyl-2-amino-1,4(2H)-imino-5-fluoropyrimidine (10), 1-beta-D-arabinofuranosyl-2-amino-1,4(2H)-imino-5-fluoropyrimidine 3'-phosphate (9), and 1-beta-D-arabinofuranosyl-2-amino-1,4(2H)-imino-5-chloropyrimidine (11) have been synthe
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32505d4a6444903ecb50bf9e130afa6d
https://doi.org/10.1021/jm00191a011
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9
Comparison of quantitative structure-activity relationships of the inhibition of leukemia cells in culture with the inhibition of dihydrofolate reductase from leukemia cells and other cell types
Autor: Zong Ru Guo, Cynthia Dias Selassie, Tasneem A. Khwaja, Corwin Hansch, Stephanie Pentecost
Publikováno v: Journal of Medicinal Chemistry. 25:153-156
A set of 2,4-diamino-5-(3-X-phenyl)-s-triazines was used to inhibit the growth of tumor cells (L5178 leukemia) in culture. The molar concentration (C) of triazine causing 50% reduction in the rate of cell growth was used to develop a quantitative str
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2682fe37abf0357602c4e3d4eb02c0d
https://doi.org/10.1021/jm00344a012
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10
Recent Studies on the Anticancer Activities of Mistletoe (Viscum album) and Its Alkaloids
Autor: Cecilia B. Dias, Tasneem A. Khwaja, Stephanie Pentecost
Publikováno v: Oncology. 43:42-50
Detailed methods for in vitro/in vivo evaluation of anticancer drugs, with special reference to mistletoe extracts, have been reviewed. Mistletoe extracts have been shown to possess significant antitumor activity, in vivo, against murine tumors, Lewi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::78a082ad258c3a9da527f61a2b47dc32
https://doi.org/10.1159/000226419
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