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Discovery of mobocertinib, a potent, oral inhibitor of EGFR exon 20 insertion mutations in non-small cell lung cancer.

Autor: Huang WS; ARIAD Pharmaceuticals, Inc., a wholly owned subsidiary of Takeda Pharmaceutical Company Limited, 26 Landsdowne Street, Cambridge, MA 02139, United States. Electronic address: weisheng.huang@theseusrx.com., Li F; ARIAD Pharmaceuticals, Inc., a wholly owned subsidiary of Takeda Pharmaceutical Company Limited, 26 Landsdowne Street, Cambridge, MA 02139, United States., Gong Y; ARIAD Pharmaceuticals, Inc., a wholly owned subsidiary of Takeda Pharmaceutical Company Limited, 26 Landsdowne Street, Cambridge, MA 02139, United States., Zhang Y; ARIAD Pharmaceuticals, Inc., a wholly owned subsidiary of Takeda Pharmaceutical Company Limited, 26 Landsdowne Street, Cambridge, MA 02139, United States., Youngsaye W; ARIAD Pharmaceuticals, Inc., a wholly owned subsidiary of Takeda Pharmaceutical Company Limited, 26 Landsdowne Street, Cambridge, MA 02139, United States., Xu Y; ARIAD Pharmaceuticals, Inc., a wholly owned subsidiary of Takeda Pharmaceutical Company Limited, 26 Landsdowne Street, Cambridge, MA 02139, United States., Zhu X; ARIAD Pharmaceuticals, Inc., a wholly owned subsidiary of Takeda Pharmaceutical Company Limited, 26 Landsdowne Street, Cambridge, MA 02139, United States., Greenfield MT; ARIAD Pharmaceuticals, Inc., a wholly owned subsidiary of Takeda Pharmaceutical Company Limited, 26 Landsdowne Street, Cambridge, MA 02139, United States., Kohlmann A; ARIAD Pharmaceuticals, Inc., a wholly owned subsidiary of Takeda Pharmaceutical Company Limited, 26 Landsdowne Street, Cambridge, MA 02139, United States., Taslimi PM; ARIAD Pharmaceuticals, Inc., a wholly owned subsidiary of Takeda Pharmaceutical Company Limited, 26 Landsdowne Street, Cambridge, MA 02139, United States., Toms A; ARIAD Pharmaceuticals, Inc., a wholly owned subsidiary of Takeda Pharmaceutical Company Limited, 26 Landsdowne Street, Cambridge, MA 02139, United States., Zech SG; ARIAD Pharmaceuticals, Inc., a wholly owned subsidiary of Takeda Pharmaceutical Company Limited, 26 Landsdowne Street, Cambridge, MA 02139, United States., Zhou T; ARIAD Pharmaceuticals, Inc., a wholly owned subsidiary of Takeda Pharmaceutical Company Limited, 26 Landsdowne Street, Cambridge, MA 02139, United States., Das B; ARIAD Pharmaceuticals, Inc., a wholly owned subsidiary of Takeda Pharmaceutical Company Limited, 26 Landsdowne Street, Cambridge, MA 02139, United States., Jang HG; ARIAD Pharmaceuticals, Inc., a wholly owned subsidiary of Takeda Pharmaceutical Company Limited, 26 Landsdowne Street, Cambridge, MA 02139, United States., Tugnait M; ARIAD Pharmaceuticals, Inc., a wholly owned subsidiary of Takeda Pharmaceutical Company Limited, 26 Landsdowne Street, Cambridge, MA 02139, United States., Ye YE; ARIAD Pharmaceuticals, Inc., a wholly owned subsidiary of Takeda Pharmaceutical Company Limited, 26 Landsdowne Street, Cambridge, MA 02139, United States., Gonzalvez F; ARIAD Pharmaceuticals, Inc., a wholly owned subsidiary of Takeda Pharmaceutical Company Limited, 26 Landsdowne Street, Cambridge, MA 02139, United States., Baker TE; ARIAD Pharmaceuticals, Inc., a wholly owned subsidiary of Takeda Pharmaceutical Company Limited, 26 Landsdowne Street, Cambridge, MA 02139, United States., Nadworny S; ARIAD Pharmaceuticals, Inc., a wholly owned subsidiary of Takeda Pharmaceutical Company Limited, 26 Landsdowne Street, Cambridge, MA 02139, United States., Ning Y; ARIAD Pharmaceuticals, Inc., a wholly owned subsidiary of Takeda Pharmaceutical Company Limited, 26 Landsdowne Street, Cambridge, MA 02139, United States., Wardwell SD; ARIAD Pharmaceuticals, Inc., a wholly owned subsidiary of Takeda Pharmaceutical Company Limited, 26 Landsdowne Street, Cambridge, MA 02139, United States., Zhang S; ARIAD Pharmaceuticals, Inc., a wholly owned subsidiary of Takeda Pharmaceutical Company Limited, 26 Landsdowne Street, Cambridge, MA 02139, United States., Gould AE; Takeda Development Center Americas, Inc, 95 Hayden Avenue, Lexington, MA 02421, United States., Hu Y; Takeda Development Center Americas, Inc, 95 Hayden Avenue, Lexington, MA 02421, United States., Lane W; Millennium Pharmaceuticals, Inc., a wholly owned subsidiary of Takeda Pharmaceutical Company Limited, 45 Landsdowne Street, Cambridge, MA 02139, United States., Skene RJ; Takeda Development Center Americas, Inc, 95 Hayden Avenue, Lexington, MA 02421, United States., Zou H; Takeda Development Center Americas, Inc, 95 Hayden Avenue, Lexington, MA 02421, United States., Clackson T; ARIAD Pharmaceuticals, Inc., a wholly owned subsidiary of Takeda Pharmaceutical Company Limited, 26 Landsdowne Street, Cambridge, MA 02139, United States., Narasimhan NI; ARIAD Pharmaceuticals, Inc., a wholly owned subsidiary of Takeda Pharmaceutical Company Limited, 26 Landsdowne Street, Cambridge, MA 02139, United States., Rivera VM; ARIAD Pharmaceuticals, Inc., a wholly owned subsidiary of Takeda Pharmaceutical Company Limited, 26 Landsdowne Street, Cambridge, MA 02139, United States., Dalgarno DC; ARIAD Pharmaceuticals, Inc., a wholly owned subsidiary of Takeda Pharmaceutical Company Limited, 26 Landsdowne Street, Cambridge, MA 02139, United States., Shakespeare WC; ARIAD Pharmaceuticals, Inc., a wholly owned subsidiary of Takeda Pharmaceutical Company Limited, 26 Landsdowne Street, Cambridge, MA 02139, United States.

Publikováno v: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2023 Jan 15; Vol. 80, pp. 129084. Date of Electronic Publication: 2022 Nov 21.