Výsledky vyhledávání - "Taskeen Fathima Docrat"

Metformin protects against neuroinflammation through integrated mechanisms of miR-141 and the NF-ĸB-mediated inflammasome pathway in a diabetic mouse model

Autor: Savania Nagiah, Anil A. Chuturgoon, Taskeen Fathima Docrat

Publikováno v: European journal of pharmacology. 903

The brain responds to diabetic stress by inducing the inflammatory response. Under normal circumstances this process is tightly regulated. However, uncontrolled inflammatory responses lead to compromised function and eventual neurodegeneration. The m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::669f1fcbe09d119e92b0733fb79b2454
https://pubmed.ncbi.nlm.nih.gov/33961875

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Sub/supercritical fluid chromatography employing water-rich modifier enables the purification of biosynthesized human insulin

Autor: Naeem Sheik Abdul, Kamini Govender, Thavendran Govender, Anil A. Chuturgoon, Tricia Naicker, Taskeen Fathima Docrat, Sooraj Baijnath, Hendrik G. Kruger

Publikováno v: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 1155

There is a paucity of knowledge surrounding the SFC purification of human insulin. The current conventional method of insulin purification involves traditional RP-HPLC that utilises copious amounts of toxic solvents. In this study, we envisaged the d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb2b9ae7d3bbf02b309c972b074f9048
https://pubmed.ncbi.nlm.nih.gov/32829141

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Atorvastatin induces MicroRNA-145 expression in HEPG2 cells via regulation of the PI3K/AKT signalling pathway

Autor: Anil A. Chuturgoon, Savania Nagiah, Taskeen Fathima Docrat, Dhaneshree Bestinee Naidoo, Anand Krishnan

Publikováno v: Chemico-Biological Interactions. 287:32-40

The use of statins as a potential cancer drug has been investigated; however the molecular mechanisms involved in their anti-oxidant, anti-proliferative and anti-cancer effects remain elusive. In our study, we investigated the involvement of downstre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6f368dca3cdceea79646656f17ffd24
https://doi.org/10.1016/j.cbi.2018.04.005

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A novel and more efficient biosynthesis approach for human insulin production in Escherichia coli (E. coli)

Autor: Kamini Govender, Anil A. Chuturgoon, Naeem Sheik Abdul, Sooraj Baijnath, Hendrik G. Kruger, Thavendran Govender, Johnson Lin, Tricia Naicker, Taskeen Fathima Docrat

Publikováno v: AMB Express
AMB Express, Vol 10, Iss 1, Pp 1-9 (2020)

Insulin has captured researchers’ attention worldwide. There is a rapid global rise in the number of diabetic patients, which increases the demand for insulin. Current methods of insulin production are expensive and time-consuming. A PCR-based stra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a194de44c3285f07d54f20bddbfd3f9
https://pubmed.ncbi.nlm.nih.gov/32152803

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The protective effect of metformin on mitochondrial dysfunction and endoplasmic reticulum stress in diabetic mice brain

Autor: Sanil D. Singh, Taskeen Fathima Docrat, Nikita Naicker, Anil A. Chuturgoon, Sooraj Baijnath, Savania Nagiah

Publikováno v: European journal of pharmacology. 875

Diabetes is a metabolic disorder associated with mitochondrial (mt) dysfunction and oxidative stress. The molecular mechanisms involved in diabetes-associated neurological complications remain elusive. This study aims to investigate the protective ef

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dde5378d7001fded57e3b0dfe1a495ad
https://pubmed.ncbi.nlm.nih.gov/32131023

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MiR-146a G/C rs2910164 variation in South African Indian and Caucasian patients with psoriatic arthritis

Autor: Shanel Dhani, Anil A. Chuturgoon, Prithiksha Ramkaran, Taskeen Fathima Docrat, Pragalathan Naidoo, Ajesh B. Maharaj, Naeem Sheik Abdul, Terisha Ghazi, Paul P. Tak, Niek de Vries

Publikováno v: BMC Medical Genetics
BMC medical genetics, 19(1):48. BioMed Central
BMC Medical Genetics, Vol 19, Iss 1, Pp 1-7 (2018)

Background Psoriasis and psoriatic arthritis (PsA) are inflammatory associated autoimmune disorders. MicroRNA (miR)-146a plays a crucial role in regulating inflammation. A single nucleotide polymorphism in the miR-146a gene (rs2910164), aberrantly al

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7019bd806b6bc676b0c4841e14c56a4b
https://pubmed.ncbi.nlm.nih.gov/29587639

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