Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Tasir Shamsul Haque"'
Autor:
Li Xin, Ming Lei, Claudio Mapelli, Tasir Shamsul Haque, Ge Zhang, John Krupinski, Sarah E. Malmstrom, Ving G. Lee, Douglas James Riexinger, Songping Han, William R. Ewing, Cooper Christopher B
Publikováno v:
Peptides. 31:950-955
We report the identification of potent agonists of the Glucagon-Like Peptide-1 Receptor (GLP-1R). These compounds are short, 11 amino acid peptides containing several unnatural amino acids, including (in particular) analogs of homohomophenylalanine (
Autor:
Ningning Liang, Dong Cheng, Mary Ann Pelleymounter, Tasir Shamsul Haque, Ramakrishna Seethala, Zhengping Ma, Michael A. Poss, William R. Ewing, Rajasree Golla, Cooper Christopher B
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:5872-5876
We report the synthesis and enzymatic evaluation of potent inhibitors of acetyl-CoA carboxylases (ACCs) containing biphenyl or 3-phenyl pyridine cores. These compounds inhibit both ACC1 and ACC2, or are moderately selective for either enzyme, dependi
Autor:
Dong Cheng, Mark R. Witmer, James K. Tamura, Jovita Marcinkeviciene, Gregory A. Locke, Robert F. Carney, Tasir Shamsul Haque, Alan R. Rendina
Publikováno v:
Archives of Biochemistry and Biophysics. 475:72-79
The role of citrate as a physiological modulator of mammalian acetyl-CoA carboxylases (ACCs) has been well studied; however, the mechanism has not been clearly defined. In the current study, we found that citrate activated recombinant human ACC2 by m
Autor:
George L. Trainor, Andrew P. Combs, Karen Amsler, Dong Liang Zhan, Andrew M. Stern, Robert A. Copeland, Tasir Shamsul Haque, Christine F. Sizemore, Lisa D. Ecret, Lisa M. Kopcho, Seifu Tadesse, Andrew M. Slee, Frank W. Hobbs, M. John Rogers, Jovita Marcinkeviciene
Publikováno v:
Journal of Medicinal Chemistry. 45:4669-4678
The identification of several potent pyrazole-based inhibitors of bacterial dihydroorotate dehydrogenase (DHODase) via a directed parallel synthetic approach is described below. The initial pyrazole-containing lead compounds were optimized for potenc
Autor:
Karen A. Amsler, Lisa M. Kopcho, Seifu Tadesse, Tasir Shamsul Haque, Jovita Marcinkeviciene, Kathy Wang, Robert A. Copeland, Andrew M. Slee, M. John Rogers, Lori Foster, Wenjun Jiang, George L. Trainor, Andrew M. Stern, Andrew P. Combs, Frank W. Hobbs, Christine F. Sizemore, Lisa D. Ecret
Publikováno v:
Journal of Biological Chemistry. 275:33373-33378
We report the discovery of a class of pyrazole-based compounds that are potent inhibitors of the dihydroorotate dehydrogenase of Helicobacter pylori but that do not inhibit the cognate enzymes from Gram-positive bacteria or humans. In culture these c
Publikováno v:
Journal of the American Chemical Society. 118:6975-6985
Spectroscopic and crystallographic data are presented for a series of tetrapeptides and analogous depsipeptides that can form a minimal β-hairpin (two intramolecular hydrogen bonds). These model compounds have been used to test the hypothesis that
Publikováno v:
Journal of the American Chemical Society. 117:6509-6519
Publikováno v:
The Journal of Organic Chemistry. 60:4108-4113
Autor:
James Devenny, Luping Chen, Anthony V. Azzara, Ningning Liang, Zhengping Ma, Dong Cheng, Petia Shipkova, Tasir Shamsul Haque, Joelle M. Onorato
Publikováno v:
Analytical and bioanalytical chemistry. 397(7)
The formation of malonyl-CoA is catalyzed by acetyl-CoA carboxylase (ACC), the rate-limiting enzyme of de novo fatty acid synthesis. Monitoring the changes of malonyl-CoA concentration in the brain in response to treatments such as pharmaceutical int
Autor:
Ving G. Lee, Tasir Shamsul Haque, Ming Feng, Douglas G. Riexinger, Rogelio L. Martinez, Claudio Mapelli, William R. Ewing, Cooper Christopher B, Ming Lei, Ge Zhang, Barry Koplowitz, John Krupinski, Christine Huang
Publikováno v:
Peptides. 31(7)
We report the identification of potent agonists of the Glucagon-Like Peptide-1 receptor (GLP-1R) via evaluation of two positional scanning libraries and a two-dimensional focused library, synthesized in part on SynPhase™ Lanterns. These compounds a